Bupranolol - 98%, high purity , CAS No.14556-46-8, Antagonist of β 1-adrenoceptor;Antagonist of β 2-adrenoceptor;Antagonist of β 3-adrenoceptor

Item Number

B275186

Grouped product items
SKU	Size	Availability	Price	Qty
B275186-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$47.90
B275186-500mg	500mg	In stock	$213.90

Potent non-selective β adrenoceptor antagonist

View related series

Basic Description

Synonyms	KL 255 \| 858YGI5PIT \| Bupranol \| Q425838 \| Bupranololum \| DTXCID202704 \| UNII-858YGI5PIT \| 1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)propan-2-ol \| D07590 \| F81732 \| KL-255 [AS HYDROCHLORIDE] \| BUPRANOLOL \| BUPRANOLOL [INN] \| 1-(tert-Butylamino)-3-(2
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Potent non-selective β adrenoceptor antagonist (K i values are 5.2, 50 and 170 nM at β 2 , β 1 and β 3 , respectively). Similar potency to propranolol.
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of β 1-adrenoceptor;Antagonist of β 2-adrenoceptor;Antagonist of β 3-adrenoceptor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

ADRB2 Tclin Beta-2 adrenergic receptor (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRB3 Tclin Beta-3 adrenergic receptor (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRB1 Tclin Beta-1 adrenergic receptor (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRB1 Tclin Adrenergic receptor beta (1214 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)propan-2-ol
INCHI	InChI=1S/C14H22ClNO2/c1-10-5-6-12(15)13(7-10)18-9-11(17)8-16-14(2,3)4/h5-7,11,16-17H,8-9H2,1-4H3
InChi Key	HQIRNZOQPUAHHV-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C(C=C1)Cl)OCC(CNC(C)(C)C)O
Isomeric SMILES	CC1=CC(=C(C=C1)Cl)OCC(CNC(C)(C)C)O
PubChem CID	2475
Molecular Weight	271.78