Bupranolol - 98%, high purity , CAS No.14556-46-8, Antagonist of β 1-adrenoceptor;Antagonist of β 2-adrenoceptor;Antagonist of β 3-adrenoceptor

Item Number
B275186
Grouped product items
SKUSizeAvailabilityPrice Qty
B275186-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$47.90
B275186-500mg
500mg
In stock
$213.90

Potent non-selective β adrenoceptor antagonist

Basic Description

SynonymsKL 255 | 858YGI5PIT | Bupranol | Q425838 | Bupranololum | DTXCID202704 | UNII-858YGI5PIT | 1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)propan-2-ol | D07590 | F81732 | KL-255 [AS HYDROCHLORIDE] | BUPRANOLOL | BUPRANOLOL [INN] | 1-(tert-Butylamino)-3-(2
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPotent non-selective β adrenoceptor antagonist (K i values are 5.2, 50 and 170 nM at β 2 , β 1 and β 3 , respectively). Similar potency to propranolol.
Storage TempStore at 2-8°C,Desiccated
Shipped InWet ice
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of β 1-adrenoceptor;Antagonist of β 2-adrenoceptor;Antagonist of β 3-adrenoceptor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

ADRB2 Tclin Beta-2 adrenergic receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRB3 Tclin Beta-3 adrenergic receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRB1 Tclin Beta-1 adrenergic receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Adrenergic receptor beta (1214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)propan-2-ol
INCHI InChI=1S/C14H22ClNO2/c1-10-5-6-12(15)13(7-10)18-9-11(17)8-16-14(2,3)4/h5-7,11,16-17H,8-9H2,1-4H3
InChi Key HQIRNZOQPUAHHV-UHFFFAOYSA-N
Canonical SMILES CC1=CC(=C(C=C1)Cl)OCC(CNC(C)(C)C)O
Isomeric SMILES CC1=CC(=C(C=C1)Cl)OCC(CNC(C)(C)C)O
PubChem CID 2475
Molecular Weight 271.78

Certificates

Certificate of Analysis(COA)

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2 results found

Lot NumberCertificate TypeDateItem
I2108137Certificate of AnalysisJul 14, 2022 B275186
I2108172Certificate of AnalysisJul 14, 2022 B275186

Chemical and Physical Properties

SolubilitySoluble in DMSO to 100 mM and in ethanol to 100 mM

Related Documents

Solution Calculators