| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| B424228-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $117.90 |
Dual c-Met and EGFR tyrosine kinase inhibitor
| Synonyms | butein | 487-52-5 | 2',3,4,4'-Tetrahydroxychalcone | 2',4',3,4-Tetrahydroxychalcone | 3,4,2',4'-Tetrahydroxychalcone | (E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one | AC1NQY7L | UNII-4WVS5M0LGF | 4WVS5M0LGF | EINECS 207-659-5 | CHEBI:3237 | NSC-652892 | (2E) |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Dual c-Met and EGFR tyrosine kinase inhibitor. Inhibits MMP-9 expression and activity. Suppresses tumor cell invasion. Induces apoptosis. Shows anti-adipogenic effects. Shows antimetastatic and antitumor effects in vivo. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR. |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| IUPAC Name | (E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one |
|---|---|
| INCHI | InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+ |
| InChi Key | AYMYWHCQALZEGT-ORCRQEGFSA-N |
| Canonical SMILES | C1=CC(=C(C=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O)O |
| Isomeric SMILES | C1=CC(=C(C=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O)O |
| WGK Germany | 3 |
| PubChem CID | 5281222 |
| Molecular Weight | 272.25 |
| Reaxy-Rn | 2056928 |
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| Sensitivity | Heat,Light &Air Sensitive |
|---|---|
| Melt Point(°C) | 215°C(lit.) |
| WGK Germany | 3 |
|---|---|
| Reaxy-Rn | 2056928 |
