Butyrolactone 3 - ≥95%, high purity , CAS No.778649-18-6

Item Number

B344763

Grouped product items
SKU	Size	Availability	Price
B344763-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$69.90
B344763-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$246.90
B344763-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$399.90
B344763-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$792.90
B344763-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,088.90
B344763-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,960.90

a histone acetyltransferase GCN5 inhibitor

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Basic Description

Synonyms	(2S,3R)-4-Methylidene-5-oxo-2-propyloxolane-3- \| CHEBI:125615 \| DTXSID60435253 \| BRD-K68584490-001-01-2 \| Butyrolactone 3 \| (2S,3R)-4-methylene-5-oxo-2-propyl-3-oxolanecarboxylic acid \| AKOS006290263 \| BDBM50371233 \| Q27216229 \| SCHEMBL23682959 \| (2S,3R)-
Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	MB-3 can modify gene expression in mouse embryonic stem cells and yeast. It inhibits the acetyltransferase activity of Universal Control Protein 5 (GCN5) by binding to the acetyl CoA pocket in GCN5. MB-3 is a Gcn5 HAT (histone acetyltransferase) inhibitor
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Butyrolactone 3, also called MB-3 is an inhibitor of Histone acetyltransferase GCN5 (general control of amino-acid synthesis 5). Gcn5 HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which allows transcription elongation by relaxing nucleosomes. Butyrolactone 3 specifically inhibits Gcn5's HAT activity. It has been shown to display anti-inflammatory and anti-carcinogenic effects.

Names and Identifiers

IUPAC Name	(2S,3R)-4-methylidene-5-oxo-2-propyloxolane-3-carboxylic acid
INCHI	InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m0/s1
InChi Key	SRQUTZJZABSZRQ-NKWVEPMBSA-N
Canonical SMILES	CCCC1C(C(=C)C(=O)O1)C(=O)O
Isomeric SMILES	CCC[C@H]1[C@@H](C(=C)C(=O)O1)C(=O)O
PubChem CID	10081070
Molecular Weight	184.19

Solubility

Soluble in DMSO, and methanol.

Refractive Index

n20D1.50 (Predicted)

Boil Point(°C)

386.21° C at 760 mmHg (Predicted)

Melt Point(°C)

60° C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help.

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Basic Description