BW 755C is a 5-lipoxygenase ( 5-LO ) inhibitor with an IC 50 of 5 μM. BW 755C also inhibits cyclooxygenase ( COX ) with IC 50 s of 0.65 and 1.2 μg/mL against COX-1 and COX-2 , respectively.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
BW 755C is a 5-lipoxygenase ( 5-LO ) inhibitor with an IC 50 of 5 μM. BW 755C also inhibits cyclooxygenase ( COX ) with IC 50 s of 0.65 and 1.2 μg/mL against COX-1 and COX-2 , respectively
In Vivo
BW 755C (0.03-10 mg/rat; s.c.; once) inhibits the ovulation rate and ovarian levels of 5-HETE and 12-HETE in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Immature Wistar rats ~22 days of ageDosage: 0.03, 0.1, 0.3, 1.0, 3.1 and 10 mg/rat Administration: Subcutaneous injection, once Result: Reduced 5-HETE (moderately) and 12-HETE (strongly).
