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BX 430 - 98%, high purity , CAS No.688309-70-8, Antagonist of P2X4

Item Number
B288181
Grouped product items
SKUSizeAvailabilityPrice Qty
B288181-5mg
5mg
In stock
$78.90
B288181-10mg
10mg
In stock
$137.90
B288181-25mg
25mg
In stock
$296.90
B288181-50mg
50mg
In stock
$494.90
B288181-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$791.90
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Selective P2X4allosteric antagonist

View related series
Calcium Channel Membrane Transporter/Ion Channel Neuronal Signaling P2X Receptor P2X4 Antagonist

Basic Description

Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsSelective P2X4allosteric antagonist (IC50= 0.54μM). Exhibits >10-fold selectivity for human P2X4receptors over P2X1, P2X2, P2X3, P2X5and P2X7receptors. Binds noncompetitively at extracellular allosteric site. Effective at human and zebrafish, but not mou
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of P2X4

Associated Targets(Human)

P2RX4 Tchem P2X purinoceptor 4 (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
P2RX5 Tchem P2X purinoceptor 5 (52 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P2RX4 Tchem P2X purinoceptor 4 (516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P2RX7 Tchem P2X purinoceptor 7 (5534 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CGA Tbio Glycoprotein hormones alpha chain (29278 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

P2rx2 P2X purinoceptor 2 (106 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 1-(2,6-dibromo-4-propan-2-ylphenyl)-3-pyridin-3-ylurea
INCHI InChI=1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21)
InChi Key JFNKIJKRXKPQCC-UHFFFAOYSA-N
Canonical SMILES CC(C)C1=CC(=C(C(=C1)Br)NC(=O)NC2=CN=CC=C2)Br
Isomeric SMILES CC(C)C1=CC(=C(C(=C1)Br)NC(=O)NC2=CN=CC=C2)Br
PubChem CID 2810999
Molecular Weight 413.11

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
B2216330Certificate of AnalysisNov 19, 2024 B288181
B2216331Certificate of AnalysisNov 19, 2024 B288181
B2216332Certificate of AnalysisNov 19, 2024 B288181
B2216346Certificate of AnalysisNov 19, 2024 B288181
B2216355Certificate of AnalysisNov 19, 2024 B288181

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 41.31, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 41.31, Max Conc. mM: 100
Sensitivitylight sensitive
Melt Point(°C)164-168°C

Safety and Hazards(GHS)

RIDADR NONHforallmodesoftransport

Related Documents

 SDS

 Specification Sheet

References

1. Ase AR, Honson NS, Zaghdane H, Pfeifer TA, Séguéla P.  (2015)  Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels..  Mol Pharmacol,  87  (4): (606-16).  [PMID:25597706] [10.1021/op500134e]

Solution Calculators

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