The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
C-DIM 12 - 10mM in DMSO, high purity , CAS No.178946-89-9
Nurr1 activator; inhibits NF-κB-dependent gene expression
Basic Description Synonyms 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole] Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Nurr1 activator. Inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. Neuroprotective in a mouse Parkinson's disease model. Orally bioavailabl Storage Temp Store at -80°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 3-[(4-chlorophenyl)-(1H-indol-3-yl)methyl]-1H-indole INCHI InChI=1S/C23H17ClN2/c24-16-11-9-15(10-12-16)23(19-13-25-21-7-3-1-5-17(19)21)20-14-26-22-8-4-2-6-18(20)22/h1-14,23,25-26H InChi Key LTLRXTDMXOFBDW-UHFFFAOYSA-N Canonical SMILES C1=CC=C2C(=C1)C(=CN2)C(C3=CC=C(C=C3)Cl)C4=CNC5=CC=CC=C54 Isomeric SMILES C1=CC=C2C(=C1)C(=CN2)C(C3=CC=C(C=C3)Cl)C4=CNC5=CC=CC=C54 PubChem CID 5302583 Molecular Weight 356.85
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
