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c-Fos Mouse mAb - Primary antibody, specific to c-Fos, Mouse IgG1

Validated

ExactAb™

1.0 mg/mL

Features and benefits

Short Overview:
mAb (7D6-A9-D4); Mouse anti Human c-Fos Antibody; WB; Unconjugated
Species reactivity(Reacts with): Human,Monkey,Rat
Isotype: Mouse IgG1

Application:

Item Number

Ab096159

Grouped product items
SKU	Size	Availability	Price
Ab096159-10μl	10μl	In stock	$66.90
Ab096159-50μl	50μl	In stock	$189.90
Ab096159-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$299.90
Ab096159-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,249.90

mAb (7D6-A9-D4); Mouse anti Human c-Fos Antibody; WB; Unconjugated

View related series

Click to view target information: FOS

Accession#:P01100 c-Fos FOS Gene ID:2353

Basic Description

Product Name	c-Fos Mouse mAb - Primary antibody, specific to c-Fos, Mouse IgG1
Synonyms	Activator protein 1 antibody; AP 1 antibody; C FOS antibody; Cellular oncogene c fos antibody; Cellular oncogene fos antibody; FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS) antibody; FBJ murine osteosarcoma viral oncogene homolog a
Specifications & Purity	ExactAb™, Validated, 1.0 mg/mL
Host species	Mouse
Specificity	c-Fos
Immunogen	Purified recombinant human FOS protein fragments expressed in E.coli (AA 1-380).
Positive Control	WB: HCT116, COS7, HeLa(TSA treated ), HeLa lysates.
Conjugation	Unconjugated
Grade	ExactAb™, Validated
Product Description	Mouse anti Human c-Fos Antibody, Monoclonal (7D6-A9-D4), could be used for WB and so on. Application: WB: 1/500-1/1000 Protein Function Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.

Product Properties

Isotype	Mouse IgG1
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein G purified
Form	Liquid
Concentration	1.0 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

FOS Tbio Proto-oncogene c-Fos (0 Activities)

Discover Target: FOS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FOS Tbio Proto-oncogene protein c-fos (1 Activities)

Discover Target: FOS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Application

Dilution info

1/500-1/1000

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0404677	Certificate of Analysis	Apr 19, 2024	Ab096159
ZJ24F0404676	Certificate of Analysis	Apr 19, 2024	Ab096159

References

1. Ye N, Ding Y, Wild C, Shen Q, Zhou J.. (2014) Small molecule inhibitors targeting activator protein 1 (AP-1).. J Med Chem, 57 (16): (6930-6948). [PMID:24831826]
2. Roux, P P and 6 more authors.. (1991) Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells.. Oncogene, [PMID:1658710]
3. Nakabeppu, Y Y and Nathans, D D.. (1989) The basic region of Fos mediates specific DNA binding.. The EMBO journal, (1): [PMID:2511004]
4. Hai, T W TW, Liu, F F, Coukos, W J WJ and Green, M R MR.. (1989) Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.. Genes & development, [PMID:2516827]
5. van Straaten, F F, Müller, R R, Curran, T T, Van Beveren, C C and Verma, I M IM.. (1983) Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:6574479]
6. Glover, J N JN and Harrison, S C SC.. (1995) Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.. Nature, (19): [PMID:7816143]
7. Zhang, Y Y, Feng, X H XH and Derynck, R R.. (1998) Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.. Nature, (27): [PMID:9732876]
8. Heilig, Roland R and 98 more authors.. (2003) The DNA sequence and analysis of human chromosome 14.. Nature, (6): [PMID:12508121]
9. Bossis, Guillaume G and 9 more authors.. (2005) Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.. Molecular and cellular biology, [PMID:16055710]
10. Portal, M M MM, Ferrero, G O GO and Caputto, B L BL.. (2007) N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation.. Oncogene, (24): [PMID:17160021]
11. Jakobs, Astrid and 5 more authors.. (2007) Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation.. Nucleic acids research, [PMID:17709345]
12. Mayya, Viveka V and 7 more authors.. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.. Science signaling, (18): [PMID:19690332]
13. Fiebich, Bernd L BL and 6 more authors.. (2012) Pseudoephedrine inhibits T-cell activation by targeting NF-κB, NFAT and AP-1 signaling pathways.. Immunopharmacology and immunotoxicology, [PMID:21631396]
14. Ferrero, G O GO, Velazquez, F N FN and Caputto, B L BL.. (2012) The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity.. Oncogene, (12): [PMID:22105363]
15. Hendriks, Ivo A; Treffers, Louise W; Verlaan-de Vries, Matty; Olsen, Jesper V and Vertegaal, Alfred C O.. (2015) SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.. Cell reports, (17): [PMID:25772364]

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