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c-Kit/CD117 Rat mAb - Primary antibody, specific to c-Kit/CD117, Rat IgG2b

Features and benefits
  • Short Overview:

    mAb (ACK2); Rat anti Mouse c-Kit/CD117 Antibody; Flow, IP, in vivo mast cell depletion, in vivo c-Kit+ cell depletion, in vitro c-Kit neutralization; Unconjugated

  • Species reactivity(Reacts with): Mouse
  • Isotype: Rat IgG2b
    Application:
  • Animal Model
  • Depletion
  • Flow Cytometry
  • Functional Assay
  • IP
  • Neutralization
Item Number
Ab096635
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab096635-10μg
10μg
In stock
$29.90
Ab096635-50μg
50μg
In stock
$69.90
Ab096635-100μg
100μg
In stock
$109.90
Ab096635-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$469.90
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mAb (ACK2); Rat anti Mouse c-Kit/CD117 Antibody; Flow, IP, in vivo mast cell depletion, in vivo c-Kit+ cell depletion, in vitro c-Kit neutralization; Unconjugated

View related series
Click to view target information: KIT
Accession#: P05532 c-Kit CD117 Gene ID: 16590

Basic Description

Product Namec-Kit/CD117 Rat mAb - Primary antibody, specific to c-Kit/CD117, Rat IgG2b
SynonymsW | Bs | Fdc | Ssm | SCO1 | SCO5 | SOW3 | c-KIT | Tr-kit | Gsfsco1 | Gsfsco5 | Gsfsow3 | CD117 antigen | CD117 | ckit | c-kit | EC 2.7.10 | EC 2.7.10.1 | KIT | PBT | piebald trait | Proto-oncogene c-Kit | proto-oncogene tyrosine-protein kinase Kit | SCF R
Specifications & PurityValidated, Azide Free, Carrier Free, ≥95%(SDS-PAGE), Lot by Lot
Host speciesRat
Specificityc-Kit/CD117
ImmunogenIL-3-dependent mast cells
ConjugationUnconjugated
GradeAzide Free, Carrier Free, Validated
Product Description

Rat anti Mouse c-Kit/CD117 Antibody, Monoclonal (ACK2), could be used for Flow, IP, in vivo mast cell depletion, in vivo c-Kit+ cell depletion, in vitro c-Kit neutralization and so on.
Application:
Flow: Use at an assay dependent concentration.
IP: Use at an assay dependent concentration.
in vivo mast cell depletion: Use at an assay dependent concentration.
in vivo c-Kit+ cell depletion: Use at an assay dependent concentration.
in vitro c-Kit neutralization: Use at an assay dependent concentration.
Protein Function
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

Product Properties

IsotypeRat IgG2b
Light Chain Typekappa
SDS-PAGE26.0 kDa (Light Chain) & 52.5 kDa (Heavy Chain), under reducing conditions; 205.4 kDa, under non-reducing conditions.
Purification MethodProtein G purified
FormLiquid
ConcentrationLot by Lot
Storage TempStore at 2-8°C,Freeze prohibited
Shipped InWet ice
Stability And StorageShipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon delivery aliquot.

Associated Targets(Human)

KIT Tclin Mast/stem cell growth factor receptor Kit (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KIT Tclin Stem cell growth factor receptor (10667 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KIT Tclin VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT) (10 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KIT Tclin VHL/KIT (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KIT Tclin Protein cereblon/Stem cell growth factor receptor (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Application

ApplicationDilution info
IP

Use at an assay dependent concentration.

Flow Cytometry

Use at an assay dependent concentration.

in vivo mast cell depletion

Use at an assay dependent concentration.

in vivo c-Kit+ cell depletion

Use at an assay dependent concentration.

in vitro c-Kit neutralization

Use at an assay dependent concentration.

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0708968Certificate of AnalysisJul 30, 2024 Ab096635
ZJ24F0708967Certificate of AnalysisJul 30, 2024 Ab096635
ZJ24F0708966Certificate of AnalysisJul 30, 2024 Ab096635

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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