| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| C275189-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $741.90 | |
| C275189-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $3,339.90 |
Potent group II/III metabotropic glutamate receptor antagonist
| Specifications & Purity | Moligand™, ≥99% |
|---|---|
| Biochemical and Physiological Mechanisms | Potent group II/III metabotropic glutamate receptor antagonist. Displays 20-fold selectivity for Group III over Group II. K i values are 11.5, 17.3 and 4.02 μM for mGlu receptor subtypes mGlu 6 mGlu 7a and mGlu 8a , respectively. |
| Storage Temp | Room temperature,Desiccated |
| Shipped In | Normal |
| Grade | Moligand™ |
| Action Type | ANTAGONIST |
| Mechanism of action | Antagonist of mGlu 4 receptor;Antagonist of mGlu 8 receptor |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description | Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IUPAC Name | 2-amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid |
|---|---|
| INCHI | InChI=1S/C11H14NO5P/c12-11(10(13)14,7-1-2-7)8-3-5-9(6-4-8)18(15,16)17/h3-7H,1-2,12H2,(H,13,14)(H2,15,16,17) |
| InChi Key | IGODGTDUQSMDQU-UHFFFAOYSA-N |
| Canonical SMILES | C1CC1C(C2=CC=C(C=C2)P(=O)(O)O)(C(=O)O)N |
| Isomeric SMILES | C1CC1C(C2=CC=C(C=C2)P(=O)(O)O)(C(=O)O)N |
| PubChem CID | 2878 |
| Molecular Weight | 271.21 |
| Solubility | Soluble in 1 eq. NaOH to 100 mM |
|---|---|
| Molecular Weight | 271.210 g/mol |
| XLogP3 | -3.100 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 4 |
| Exact Mass | 271.061 Da |
| Monoisotopic Mass | 271.061 Da |
| Topological Polar Surface Area | 121.000 Ų |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Complexity | 383.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H302:Harmful if swallowed |
| Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
