CPPG - ≥99%, high purity , CAS No.183364-82-1, Antagonist of mGlu 4 receptor;Antagonist of mGlu 8 receptor

Item Number
C275189
Grouped product items
SKUSizeAvailabilityPrice Qty
C275189-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$741.90
C275189-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$3,339.90

Potent group II/III metabotropic glutamate receptor antagonist

Basic Description

Synonymscppg | 183364-82-1 | 2-amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid | (RS)-CPPG | C11H14NO5P | CHEMBL164642 | GTPL1413 | SCHEMBL7370655 | CHEBI:125380 | CPPG, >=98% (HPLC) | HB0217 | AKOS024458717 | NCGC00024912-02 | alpha-cyclopropyl-4-phosphonophenylglycine | HY-101333 | (RS
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsPotent group II/III metabotropic glutamate receptor antagonist. Displays 20-fold selectivity for Group III over Group II. K i values are 11.5, 17.3 and 4.02 μM for mGlu receptor subtypes mGlu 6 mGlu 7a and mGlu 8a , respectively.
Storage TempRoom temperature,Desiccated
Shipped InNormal
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of mGlu 4 receptor;Antagonist of mGlu 8 receptor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

GRM4 Tchem Metabotropic glutamate receptor 4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRM8 Tchem Metabotropic glutamate receptor 8 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid
INCHI InChI=1S/C11H14NO5P/c12-11(10(13)14,7-1-2-7)8-3-5-9(6-4-8)18(15,16)17/h3-7H,1-2,12H2,(H,13,14)(H2,15,16,17)
InChi Key IGODGTDUQSMDQU-UHFFFAOYSA-N
Canonical SMILES C1CC1C(C2=CC=C(C=C2)P(=O)(O)O)(C(=O)O)N
Isomeric SMILES C1CC1C(C2=CC=C(C=C2)P(=O)(O)O)(C(=O)O)N
PubChem CID 2878
Molecular Weight 271.21

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in 1 eq. NaOH to 100 mM

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

Related Documents

Solution Calculators