| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab005524-10μg | 10μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $29.90 | |
| Ab005524-50μg | 50μg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $87.90 | |
| Ab005524-100μg | 100μg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $117.90 | |
| Ab005524-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $417.90 |
mAb(4F8), Mouse anti Human CA125 Antibody; Detection antibody, ELISA, CLIA; Unconjugated
| Product Name | CA125 Mouse mAb - Primary antibody, for ELISA,CLIA various applications, from Human, generated in Rat, specific to Antibody recognizes human cancer antigen 125 (CA125), IgG2a |
|---|---|
| Synonyms | CA-125 | MUC-16 | Ovarian cancer-related tumor marker CA125 | Ovarian carcinoma antigen CA125 |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Azide Free, Lot by Lot |
| Host Species | Rat |
| Host species | Mouse |
| Specificity | Antibody recognizes human cancer antigen 125 (CA125) |
| Application | ELISA,CLIA |
| Immunogen | E. coli-derived recombinant human CA125 |
| Epitope | DomainA（表位类M11） |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Validated |
| Product Description | Monoclonal (4F8), Mouse anti Human CA125 Antibody could used as the capture antibody in ELISA, CLIA at 1.0 μg/mL. |
| Antibody Type | Primary antibody |
|---|---|
| Clonality | Monoclonal antibodies |
| Isotype | IgG2a |
| Dissociation constant(KD) | Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. |
| Purification Method | Protein A purified |
| Matched Pairs | [Ab005528] CA125 Mouse mAb as capture antibody in ELISA, CLIA. |
| Source | Hybridoma supernatant |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Storage: -20℃ for long term storage. Avoid repeated freeze / thaw cycles. |
Relevance of detection results between aladdin Antibody Pair (Ab005528 & Ab005524) and Roche in CLIA
· Capture antibody: CA125 Mouse mAb (Ab005528) at 1.0 μg/mL.
· Detection antibody: CA125 Mouse mAb (Ab005524) at 1.0 μg/mL.
· Linear Range: 0.6-5000 U/mL, R2 ≥ 0.98.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Application | Dilution info |
|---|---|
| ELISA |
1 μg/mL |
| CLIA |
1 μg/mL
|
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ23F0500247 | Certificate of Analysis | Jun 05, 2023 | Ab005524 |
| ZJ23F0500249 | Certificate of Analysis | Jun 05, 2023 | Ab005524 |
| 1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K et al.. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat Genet, 36 (1): (40-5). [PMID:14702039] [10.1021/op500134e] |
| 2. Yin, B W BW and Lloyd, K O KO.. (2001) Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16.. The Journal of biological chemistry, (20): [PMID:11369781] |
| 3. O'Brien, T J TJ and 5 more authors.. () The CA 125 gene: an extracellular superstructure dominated by repeat sequences.. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, [PMID:11786729] |
| 4. O'Brien, Timothy J TJ, Beard, John B JB, Underwood, Lowell J LJ and Shigemasa, Kazushi K.. () The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure.. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, [PMID:12218296] |
| 5. Kui Wong, Nyet N and 9 more authors.. (2003) Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125.. The Journal of biological chemistry, (1): [PMID:12734200] |
| 6. Rump, Armin A and 6 more authors.. (2004) Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion.. The Journal of biological chemistry, (5): [PMID:14676194] |
| 7. Grimwood, Jane J and 97 more authors.. (2004) The DNA sequence and biology of human chromosome 19.. Nature, (1): [PMID:15057824] |
| 8. McLemore, Monica R MR and Aouizerat, Bradley B.. (2005) Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer.. Biological research for nursing, [PMID:15788735] |
| 9. Argüeso, Pablo P, Tisdale, Ann A, Spurr-Michaud, Sandra S, Sumiyoshi, Mika M and Gipson, Ilene K IK.. (2006) Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye.. Investigative ophthalmology & visual science, [PMID:16384952] |
