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CaCCinh-A01 - 10mM in DMSO, high purity , CAS No.407587-33-1
Calcium-activated chloride channel (CaCC) inhibitor
Basic Description
| Synonyms | 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid |
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| Specifications & Purity | Moligand™, 10mM in DMSO |
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| Biochemical and Physiological Mechanisms | Calcium-activated chloride channel (CaCC) inhibitor (IC50~ 10μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50= 2.1μM, in TMEM16A-expressing FRT cells). |
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| Storage Temp | Store at -80°C |
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| Shipped In | Ice chest + Ice pads |
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| Grade | Moligand™ |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 6-tert-butyl-2-(furan-2-carbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid |
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| INCHI | InChI=1S/C18H21NO4S/c1-18(2,3)10-6-7-11-13(9-10)24-16(14(11)17(21)22)19-15(20)12-5-4-8-23-12/h4-5,8,10H,6-7,9H2,1-3H3,(H,19,20)(H,21,22) |
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| InChi Key | ACLUEOBQFRYTQS-UHFFFAOYSA-N |
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| Canonical SMILES | CC(C)(C)C1CCC2=C(C1)SC(=C2C(=O)O)NC(=O)C3=CC=CO3 |
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| Isomeric SMILES | CC(C)(C)C1CCC2=C(C1)SC(=C2C(=O)O)NC(=O)C3=CC=CO3 |
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| PubChem CID | 2898877 |
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| Molecular Weight | 347.43 |
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