Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C302986-200mg | 200mg | In stock | $39.90 | |
C302986-1g | 1g | In stock | $136.90 |
Synonyms | calcein | Fluorexon | 1461-15-0 | Oftasceine | Oftasceinum | Oftasceina | 2,2',2'',2'''-(((3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-2',7'-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid | 154071-48-4 | Oftasceine [INN] | NSC-298193 | V0YM2B16TS | 2',7'- |
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Specifications & Purity | Isomer mixture |
Biochemical and Physiological Mechanisms | Calcein is a calcium-dependent fluorescent molecule. It is mainly required to study bone metabolism under in vivo conditions and helps in the staining of pit area under in vitro conditions.Calcein is used for the fluorometric determination of calcium and |
Storage Temp | Room temperature,Desiccated |
Shipped In | Normal |
Product Description | Application: Calcein has been used: in whole cell staining; in histomorphometry and micro-computed tomography; to label active bone-forming surfaces. |
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IUPAC Name | 2-[[7'-[[bis(carboxymethyl)amino]methyl]-3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-2'-yl]methyl-(carboxymethyl)amino]acetic acid |
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INCHI | InChI=1S/C30H26N2O13/c33-21-7-23-19(5-15(21)9-31(11-25(35)36)12-26(37)38)30(18-4-2-1-3-17(18)29(43)45-30)20-6-16(22(34)8-24(20)44-23)10-32(13-27(39)40)14-28(41)42/h1-8,33-34H,9-14H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42) |
InChi Key | DEGAKNSWVGKMLS-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C2C(=C1)C(=O)OC23C4=C(C=C(C(=C4)CN(CC(=O)O)CC(=O)O)O)OC5=C3C=C(C(=C5)O)CN(CC(=O)O)CC(=O)O |
Isomeric SMILES | C1=CC=C2C(=C1)C(=O)OC23C4=C(C=C(C(=C4)CN(CC(=O)O)CC(=O)O)O)OC5=C3C=C(C(=C5)O)CN(CC(=O)O)CC(=O)O |
Alternate CAS | 1461-15-0 |
PubChem CID | 65079 |
Molecular Weight | 622.54 |
Enter Lot Number to search for COA:
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Lot Number | Certificate Type | Date | Item |
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G2422030 | Certificate of Analysis | Jul 09, 2024 | C302986 |
G2422031 | Certificate of Analysis | Jul 09, 2024 | C302986 |
B2418272 | Certificate of Analysis | Jan 25, 2024 | C302986 |
B2418273 | Certificate of Analysis | Jan 25, 2024 | C302986 |
B2322142 | Certificate of Analysis | Feb 11, 2023 | C302986 |
B2322148 | Certificate of Analysis | Feb 11, 2023 | C302986 |
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1. Xiaoyu Lei, Boyuan Yang, Jie Chen, Fang Yang, Jiajing Tang, Jihua Li, Qing Zhao, Jinzheng Zhang, Jidong Li, Yubao Li, Yi Zuo. (2023) Biodegradable Polyurethane Scaffolds in Regeneration Therapy: Characterization and In Vivo Real-Time Degradation Monitoring by Grafted Fluorescent Tracer. ACS Applied Materials & Interfaces, [PMID:38112686] |
2. Yongzhi Cui, Bin Lv, Zhongying Li, Chunming Ma, Zhengwei Gui, Yongtao Geng, Guohui Liu, Linchao Sang, Chen Xu, Qi Min, Li Kong, Zhiping Zhang, Yang Liu, Xiangbei Qi, Dehao Fu. (2023) Bone-Targeted Biomimetic Nanogels Re-Establish Osteoblast/Osteoclast Balance to Treat Postmenopausal Osteoporosis. Small, (1): (2303494). [PMID:37794621] |
3. Shuofeng Li, Fangfang Wang, Bin Zhao, Chun Wang, Zhi Wang, Qiuhua Wu. (2023) MnO2 nanoflowers based colorimetric and fluorescent dual-mode aptasensor for sensitive detection of aflatoxin B1 in milk. ANALYTICA CHIMICA ACTA, 1279 (2): (341844). [PMID:37827626] |
4. Min Wu, Yi Hu, Mengran Xu, Lijuan Fu, Chengpan Li, Jingjing Wu, Xin Sun, Wenshen Wang, Shaozhen Wang, Ting Wang, Weiping Ding, Ping Li. (2023) Transdermal delivery of brucine-encapsulated liposomes significantly enhances anti-tumor outcomes in treating triple-negative breast cancer. Biomaterials Advances, 153 (213566). [PMID:37536027] |
5. Bin Liu, Yanlan Wang, Na Du. (2023) Interactions between Layered Double Hydroxide Nanoparticles and Egg Yolk Lecithin Liposome Membranes. MOLECULES, 28 (9): (3929). [PMID:37175337] |
6. Shi-Jie Hao, Ya-Xuan Zhu, Fu-Gen Wu. (2023) Membrane fusion-mediated delivery of small-molecule HER2 tyrosine kinase inhibitor for effective tumor chemosensitization. JOURNAL OF CONTROLLED RELEASE, 357 (222). [PMID:36958404] |
7. Qiji Lu, Jingjing Diao, Yingqu Wang, Jianlang Feng, Fansen Zeng, Yan Yang, Yudi Kuang, Naru Zhao, Yingjun Wang. (2023) 3D printed pore morphology mediates bone marrow stem cell behaviors via RhoA/ROCK2 signaling pathway for accelerating bone regeneration. Bioactive Materials, 26 (413). [PMID:36969106] |
8. Peng Ye, Wendian Zhang, Tan Yang, Yao Lu, Miao Lu, Yongkang Gai, Xiang Ma, Guangya Xiang. (2023) Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting. International Journal of Nanomedicine, [PMID:24855354] |
9. Lang Chen, Chenyan Yu, Wanting Xu, Yuan Xiong, Peng Cheng, Ze Lin, Zhenhe Zhang, Leonard Knoedler, Adriana C. Panayi, Samuel Knoedler, Junqing Wang, Bobin Mi, Guohui Liu. (2023) Dual-Targeted Nanodiscs Revealing the Cross-Talk between Osteogenic Differentiation of Mesenchymal Stem Cells and Macrophages. ACS Nano, 17 (3): (3153–3167). [PMID:36715347] |
10. Suping Jiang, Wen Wang, Jiming Ke, Shan Huang, Jie Wang, Chengxi Luo, Xiaoxia Li, Kaili Zhang, Huanhuan Liu, Wensheng Zheng, Jiwen Zhang, Can Peng. (2023) A mechanically tough and ultra-swellable microneedle for acute gout arthritis. Biomaterials Science, 11 (5): (1714-1724). [PMID:36629000] |
11. Xinhui Wang, Yuan Ma, Xingtang Niu, Ting Su, Xiaoqi Huang, Feng Lu, Qiang Chang. (2022) Direct three-dimensional printed egg white hydrogel wound dressing promotes wound healing with hitching adipose stem cells. Frontiers in Bioengineering and Biotechnology, 10 (930551). [PMID:36072289] |
12. Yongzhi Cui, Zhongying Li, Yuanyuan Guo, Xiangbei Qi, Yuehua Yang, Xiong Jia, Rui Li, Jingyu Shi, Weihang Gao, Zhengwei Ren, Guohui Liu, Qingsong Ye, Zhiping Zhang, Dehao Fu. (2022) Bioinspired Nanovesicles Convert the Skeletal Endothelium-Associated Secretory Phenotype to Treat Osteoporosis. ACS Nano, 16 (7): (11076–11091). [PMID:35801837] |
13. Chang Shu, Zhenzhen Zhang, Xiaojun Li, Jiajia Xu, Mengqi Pan, Yadong Chen, Yuqing Lei, Zhiyong Li, Qiaojie Luo, Xiaodong Li. (2022) Refactoring phosphorylated hydrogel-like interface of demineralized dentin matrix via actively induced formation of nano-ACPs forms a defect-low hybrid layer promoting adhesive dentistry. CHEMICAL ENGINEERING JOURNAL, 450 (137945). [PMID:] |
14. Ruirui Sun, Jiapeng Yang, Rong Huang, Chongqing Wang. (2022) Controlled carbonization of microplastics loaded nano zero-valent iron for catalytic degradation of tetracycline. CHEMOSPHERE, 303 (135123). [PMID:35643161] |
15. Huang Yiqian, Du Zhiyun, Li Ke, Jing Wei, Wei Pengfei, Zhao Bo, Yu Yingjie, Cai Qing, Yang Xiaoping. (2022) ROS-Scavenging Electroactive Polyphosphazene-Based Core–Shell Nanofibers for Bone Regeneration. Advanced Fiber Materials, 4 (4): (894-907). [PMID:] |
16. Feixue Gong, Na Du, Wanguo Hou. (2022) Vesicle formation of single-tailed amphiphilic alkyltrimethylammonium bromides in water induced by dehydration–rehydration. Soft Matter, 18 (10): (2072-2081). [PMID:35199818] |
17. Ruoxi Zhao, Rui Zhang, Lili Feng, Yushan Dong, Jialing Zhou, Songnan Qu, Shili Gai, Dan Yang, He Ding, Piaoping Yang. (2022) Constructing virus-like SiOx/CeO2/VOx nanozymes for 1064 nm light-triggered mild-temperature photothermal therapy and nanozyme catalytic therapy. Nanoscale, 14 (2): (361-372). [PMID:34878482] |
18. Xiyue Xie, Zhenqiang Wang, Meizhen Zhou, Yuxin Xing, Yuhua Chen, Jixi Huang, Kaiyong Cai, Jixi Zhang. (2021) Redox Host–Guest Nanosensors Installed with DNA Gatekeepers for Immobilization-Free and Ratiometric Electrochemical Detection of miRNA. Small Methods, 5 (12): (2101072). [PMID:34928007] |
19. Zefeng Wang, Yanling Peng, Yan Zhou, Shengnan Zhang, Jianxi Tan, Huan Li, Dinggeng He, Le Deng. (2022) Pd-Cu nanoalloy for dual stimuli-responsive chemo-photothermal therapy against pathogenic biofilm bacteria. Acta Biomaterialia, 137 (276). [PMID:34715367] |
20. Yang Xin, Yu Qiuxia, Xu Hao, Zhou Jianfeng. (2021) Upregulation of CD22 by Chidamide promotes CAR T cells functionality. Scientific Reports, 11 (1): (1-9). [PMID:34667217] |
21. Huifang Xu, Na Du, Yawen Song, Shue Song, Wanguo Hou,. (2017-09-16) Spontaneous vesicle formation and vesicle-to-micelle transition of sodium 2-ketooctanate in water.. Journal of colloid and interface science, ( 265-274 ). [PMID:28915484] |
22. Nan Ding,Yao Lu,Robert J Lee,Chang Yang,Lei Huang,Jian Liu,Guangya Xiang. (2011-11-11) Folate receptor-targeted fluorescent paramagnetic bimodal liposomes for tumor imaging.. International journal of nanomedicine, 6 (2513-2520). [PMID:22072885] |
1. Xiaoyu Lei, Boyuan Yang, Jie Chen, Fang Yang, Jiajing Tang, Jihua Li, Qing Zhao, Jinzheng Zhang, Jidong Li, Yubao Li, Yi Zuo. (2023) Biodegradable Polyurethane Scaffolds in Regeneration Therapy: Characterization and In Vivo Real-Time Degradation Monitoring by Grafted Fluorescent Tracer. ACS Applied Materials & Interfaces, [PMID:38112686] |
2. Yongzhi Cui, Bin Lv, Zhongying Li, Chunming Ma, Zhengwei Gui, Yongtao Geng, Guohui Liu, Linchao Sang, Chen Xu, Qi Min, Li Kong, Zhiping Zhang, Yang Liu, Xiangbei Qi, Dehao Fu. (2023) Bone-Targeted Biomimetic Nanogels Re-Establish Osteoblast/Osteoclast Balance to Treat Postmenopausal Osteoporosis. Small, (1): (2303494). [PMID:37794621] |
3. Shuofeng Li, Fangfang Wang, Bin Zhao, Chun Wang, Zhi Wang, Qiuhua Wu. (2023) MnO2 nanoflowers based colorimetric and fluorescent dual-mode aptasensor for sensitive detection of aflatoxin B1 in milk. ANALYTICA CHIMICA ACTA, 1279 (2): (341844). [PMID:37827626] |
4. Min Wu, Yi Hu, Mengran Xu, Lijuan Fu, Chengpan Li, Jingjing Wu, Xin Sun, Wenshen Wang, Shaozhen Wang, Ting Wang, Weiping Ding, Ping Li. (2023) Transdermal delivery of brucine-encapsulated liposomes significantly enhances anti-tumor outcomes in treating triple-negative breast cancer. Biomaterials Advances, 153 (213566). [PMID:37536027] |
5. Bin Liu, Yanlan Wang, Na Du. (2023) Interactions between Layered Double Hydroxide Nanoparticles and Egg Yolk Lecithin Liposome Membranes. MOLECULES, 28 (9): (3929). [PMID:37175337] |
6. Shi-Jie Hao, Ya-Xuan Zhu, Fu-Gen Wu. (2023) Membrane fusion-mediated delivery of small-molecule HER2 tyrosine kinase inhibitor for effective tumor chemosensitization. JOURNAL OF CONTROLLED RELEASE, 357 (222). [PMID:36958404] |
7. Qiji Lu, Jingjing Diao, Yingqu Wang, Jianlang Feng, Fansen Zeng, Yan Yang, Yudi Kuang, Naru Zhao, Yingjun Wang. (2023) 3D printed pore morphology mediates bone marrow stem cell behaviors via RhoA/ROCK2 signaling pathway for accelerating bone regeneration. Bioactive Materials, 26 (413). [PMID:36969106] |
8. Peng Ye, Wendian Zhang, Tan Yang, Yao Lu, Miao Lu, Yongkang Gai, Xiang Ma, Guangya Xiang. (2023) Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting. International Journal of Nanomedicine, [PMID:24855354] |
9. Lang Chen, Chenyan Yu, Wanting Xu, Yuan Xiong, Peng Cheng, Ze Lin, Zhenhe Zhang, Leonard Knoedler, Adriana C. Panayi, Samuel Knoedler, Junqing Wang, Bobin Mi, Guohui Liu. (2023) Dual-Targeted Nanodiscs Revealing the Cross-Talk between Osteogenic Differentiation of Mesenchymal Stem Cells and Macrophages. ACS Nano, 17 (3): (3153–3167). [PMID:36715347] |
10. Suping Jiang, Wen Wang, Jiming Ke, Shan Huang, Jie Wang, Chengxi Luo, Xiaoxia Li, Kaili Zhang, Huanhuan Liu, Wensheng Zheng, Jiwen Zhang, Can Peng. (2023) A mechanically tough and ultra-swellable microneedle for acute gout arthritis. Biomaterials Science, 11 (5): (1714-1724). [PMID:36629000] |
11. Xinhui Wang, Yuan Ma, Xingtang Niu, Ting Su, Xiaoqi Huang, Feng Lu, Qiang Chang. (2022) Direct three-dimensional printed egg white hydrogel wound dressing promotes wound healing with hitching adipose stem cells. Frontiers in Bioengineering and Biotechnology, 10 (930551). [PMID:36072289] |
12. Yongzhi Cui, Zhongying Li, Yuanyuan Guo, Xiangbei Qi, Yuehua Yang, Xiong Jia, Rui Li, Jingyu Shi, Weihang Gao, Zhengwei Ren, Guohui Liu, Qingsong Ye, Zhiping Zhang, Dehao Fu. (2022) Bioinspired Nanovesicles Convert the Skeletal Endothelium-Associated Secretory Phenotype to Treat Osteoporosis. ACS Nano, 16 (7): (11076–11091). [PMID:35801837] |
13. Chang Shu, Zhenzhen Zhang, Xiaojun Li, Jiajia Xu, Mengqi Pan, Yadong Chen, Yuqing Lei, Zhiyong Li, Qiaojie Luo, Xiaodong Li. (2022) Refactoring phosphorylated hydrogel-like interface of demineralized dentin matrix via actively induced formation of nano-ACPs forms a defect-low hybrid layer promoting adhesive dentistry. CHEMICAL ENGINEERING JOURNAL, 450 (137945). [PMID:] |
14. Ruirui Sun, Jiapeng Yang, Rong Huang, Chongqing Wang. (2022) Controlled carbonization of microplastics loaded nano zero-valent iron for catalytic degradation of tetracycline. CHEMOSPHERE, 303 (135123). [PMID:35643161] |
15. Huang Yiqian, Du Zhiyun, Li Ke, Jing Wei, Wei Pengfei, Zhao Bo, Yu Yingjie, Cai Qing, Yang Xiaoping. (2022) ROS-Scavenging Electroactive Polyphosphazene-Based Core–Shell Nanofibers for Bone Regeneration. Advanced Fiber Materials, 4 (4): (894-907). [PMID:] |
16. Feixue Gong, Na Du, Wanguo Hou. (2022) Vesicle formation of single-tailed amphiphilic alkyltrimethylammonium bromides in water induced by dehydration–rehydration. Soft Matter, 18 (10): (2072-2081). [PMID:35199818] |
17. Ruoxi Zhao, Rui Zhang, Lili Feng, Yushan Dong, Jialing Zhou, Songnan Qu, Shili Gai, Dan Yang, He Ding, Piaoping Yang. (2022) Constructing virus-like SiOx/CeO2/VOx nanozymes for 1064 nm light-triggered mild-temperature photothermal therapy and nanozyme catalytic therapy. Nanoscale, 14 (2): (361-372). [PMID:34878482] |
18. Xiyue Xie, Zhenqiang Wang, Meizhen Zhou, Yuxin Xing, Yuhua Chen, Jixi Huang, Kaiyong Cai, Jixi Zhang. (2021) Redox Host–Guest Nanosensors Installed with DNA Gatekeepers for Immobilization-Free and Ratiometric Electrochemical Detection of miRNA. Small Methods, 5 (12): (2101072). [PMID:34928007] |
19. Zefeng Wang, Yanling Peng, Yan Zhou, Shengnan Zhang, Jianxi Tan, Huan Li, Dinggeng He, Le Deng. (2022) Pd-Cu nanoalloy for dual stimuli-responsive chemo-photothermal therapy against pathogenic biofilm bacteria. Acta Biomaterialia, 137 (276). [PMID:34715367] |
20. Yang Xin, Yu Qiuxia, Xu Hao, Zhou Jianfeng. (2021) Upregulation of CD22 by Chidamide promotes CAR T cells functionality. Scientific Reports, 11 (1): (1-9). [PMID:34667217] |
21. Huifang Xu, Na Du, Yawen Song, Shue Song, Wanguo Hou,. (2017-09-16) Spontaneous vesicle formation and vesicle-to-micelle transition of sodium 2-ketooctanate in water.. Journal of colloid and interface science, ( 265-274 ). [PMID:28915484] |
22. Nan Ding,Yao Lu,Robert J Lee,Chang Yang,Lei Huang,Jian Liu,Guangya Xiang. (2011-11-11) Folate receptor-targeted fluorescent paramagnetic bimodal liposomes for tumor imaging.. International journal of nanomedicine, 6 (2513-2520). [PMID:22072885] |