25-Hydroxyvitamin D3 is the major circulating form of vitamin D.Principal cholecalciferol metabolite. Downregulates TLR4 and JAK1/STAT3 signaling. Hydroxylates to calcitriol in vivo . Anti-inflammatory effects. Orally active.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Calcifediol is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It also suppresses PTH secretion and mRNA (ED50=2 nM). A major circulating metabolite of vitamin D3
1.He Qiting, Qin Ruixi, Glowacki Julie, Zhou Shuanhu, Shi Jie, Wang Shaoyi, Gao Yuan, Cheng Lei. (2021) Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D3 is mediated by inhibition of chaperone-mediated autophagy. Stem Cell Research & Therapy, 12 (1):(1-13). [PMID:34717752]
References
1.He Qiting, Qin Ruixi, Glowacki Julie, Zhou Shuanhu, Shi Jie, Wang Shaoyi, Gao Yuan, Cheng Lei. (2021) Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D3 is mediated by inhibition of chaperone-mediated autophagy. Stem Cell Research & Therapy, 12 (1):(1-13). [PMID:34717752]
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F2413053