Click Here for 5% Off Your First Aladdin Purchase!

calcitriol - 97%, high purity , CAS No.32222-06-3, Agonist of Vitamin D receptor

  • Moligand™
  • ≥97%
Item Number
C120126
Grouped product items
SKUSizeAvailabilityPrice Qty
C120126-1mg
1mg
In stock
$48.90
C120126-5mg
5mg
In stock
$147.90
C120126-25mg
25mg
In stock
$666.90
C120126-100mg
100mg
In stock
$1,187.90

Most active form of vitamin D

View related series
Vitamin D receptor Agonist

Basic Description

Synonymscalcitriol|Rocaltrol|Calcijex|32222-06-3|Topitriol|1alpha,25-Dihydroxyvitamin D3|Silkis|1alpha,25-Dihydroxycholecalciferol|Soltriol|Vectical|1,25-DHCC|Calcitriolum|1,25-DIHYDROXYCHOLECALCIFEROL|1,25-Dihydroxyvitamin D3|1,25-Dihydroxyvitamin D|1alpha,25(OH
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsCalcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D.Active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) displays calcemic actions. Calcitriol
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of Vitamin D receptor
NoteNeed more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Properties

ALogP5.1

Associated Targets

CNBD1 Tdark Cyclic nucleotide-binding domain-containing protein 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CNR1 Tclin Cannabinoid receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DRD2 Tclin D(2) dopamine receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ESR1 Tclin Estrogen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RARG Tclin Retinoic acid receptor gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AVPR1A Tclin Vasopressin V1a receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HRH1 Tclin Histamine H1 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DRD3 Tclin D(3) dopamine receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA2A Tclin Adenosine receptor A2a 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRB1 Tclin Beta-1 adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AR Tclin Androgen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR2C Tclin 5-hydroxytryptamine receptor 2C 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRK1 Tclin Kappa-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MLNR Tchem Motilin receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488195207
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488195207
IUPAC Name (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
INCHI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
InChi Key GMRQFYUYWCNGIN-NKMMMXOESA-N
Canonical SMILES CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
Isomeric SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C
WGK Germany 3
RTECS FZ4645000
PubChem CID 5280453
Molecular Weight 416.64
Beilstein 7559394
Reaxy-Rn 2227647

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

10 results found

Lot NumberCertificate TypeDateItem
E2324619Certificate of AnalysisMay 10, 2023 C120126
E2324634Certificate of AnalysisMay 10, 2023 C120126
E2324635Certificate of AnalysisMay 10, 2023 C120126
E2324656Certificate of AnalysisMay 10, 2023 C120126
E2324658Certificate of AnalysisMay 10, 2023 C120126
E2324661Certificate of AnalysisMay 10, 2023 C120126
I1425041Certificate of AnalysisJul 19, 2022 C120126
G2219294Certificate of AnalysisJun 21, 2022 C120126
G2219296Certificate of AnalysisJun 21, 2022 C120126
G2219467Certificate of AnalysisJun 21, 2022 C120126

Chemical and Physical Properties

SensitivityAir Sensitive,Heat Sensitive
Melt Point(°C)119°C(lit.)

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08
Signal Danger
Hazard Statements

H300:Fatal if swallowed

H310:Fatal in contact with skin

H330:Fatal if inhaled

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P330:Rinse mouth.

P262:Do not get in eyes, on skin, or on clothing.

P320:Specific treatment is urgent (see ... on this label).

P361+P364:Take off immediately all contaminated clothing and wash it before reuse.

P203:Obtain, read and follow all safety instructions before use.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P318:if exposed or concerned, get medical advice.

P316:Get emergency medical help immediately.

WGK Germany 3
RTECS FZ4645000
Reaxy-Rn 2227647
Merck Index 1644

Related Documents

References

1. Wu Y et al..  (2021)  The Activation of ROS/NF-?B/MMP-9 Pathway Promotes Calcium-Induced Kidney Crystal Deposition..  Oxid Med Cell Longev,  2021  (8836355).  [PMID:34211634]
2. Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ.  (2014)  The role of vitamin D in reducing cancer risk and progression..  Nat Rev Cancer,  14  (5): (342-57).  [PMID:24705652]
3. Tomomi Noguchi,Hiroyuki Miyachi,Ryohei Katayama,Mikihiko Naito,Yuichi Hashimoto.  (2005-06-07)  Cell differentiation inducers derived from thalidomide..  Bioorganic & medicinal chemistry letters,  15  ((13)): (3212-3215).  [PMID:15936192]
4. Matthew D Griffin,Rajiv Kumar.  (2005-07-20)  Multiple potential clinical benefits for 1alpha,25-dihydroxyvitamin D3 analogs in kidney transplant recipients..  The Journal of steroid biochemistry and molecular biology,  97  ((1-2)): (213-218).  [PMID:16026980]
5. José Manuel González-Sancho,María Jesús Larriba,Paloma Ordóñez-Morán,Héctor G Pálmer,Alberto Muñoz.  (2006-08-05)  Effects of 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells..  Anticancer research,  26  ((4A)): (2669-2681).  [PMID:16886677]
6. Hisashi Matsuda,Kazutoshi Yoshida,Katsutoshi Miyagawa,Yasunobu Asao,Saya Takayama,Souichi Nakashima,Fengming Xu,Masayuki Yoshikawa.  (2006-12-13)  Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa..  Bioorganic & medicinal chemistry,  15  ((3)): (1539-1546).  [PMID:17158054]
7. Grazia Chiellini,Pawel Grzywacz,Lori A Plum,Rafal Barycki,Margaret Clagett-Dame,Hector F DeLuca.  (2008-08-30)  Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists..  Bioorganic & medicinal chemistry,  16  ((18)): (8563-8573).  [PMID:18722130]
8. Michael B Zemel,Xiaocun Sun.  (2008-12-05)  Calcitriol and energy metabolism..  Nutrition reviews,  66  ((10 Suppl 2)): (S139-S146).  [PMID:18844841]
9. Katarzyna Plonska-Ocypa,Rafal R Sicinski,Lori A Plum,Pawel Grzywacz,Jadwiga Frelek,Margaret Clagett-Dame,Hector F DeLuca.  (2009-01-27)  13-Methyl-substituted des-C,D analogs of (20S)-1alpha,25-dihydroxy-2-methylene-19-norvitamin D3 (2MD): synthesis and biological evaluation..  Bioorganic & medicinal chemistry,  17  ((4)): (1747-1763).  [PMID:19167893]
10. Yuka Inaba,Nobuko Yoshimoto,Yuta Sakamaki,Makoto Nakabayashi,Teikichi Ikura,Hirokazu Tamamura,Nobutoshi Ito,Masato Shimizu,Keiko Yamamoto.  (2009-02-06)  A new class of vitamin D analogues that induce structural rearrangement of the ligand-binding pocket of the receptor..  Journal of medicinal chemistry,  52  ((5)): (1438-1449).  [PMID:19193059]
11. Gilles Laverny,Giuseppe Penna,Milan Uskokovic,Stanislaw Marczak,Hubert Maehr,Pawel Jankowski,Caroline Ceailles,Paul Vo.  (2009-03-25)  Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3..  Journal of medicinal chemistry,  52  ((8)): (2204-2213).  [PMID:19309155]
12. N Carrillo-López,J L Fernández-Martín,J B Cannata-Andía.  (2009-04-28)  [The role of calcium, calcitriol and their receptors in parathyroid regulation]..  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia,  29  ((2)): (103-108).  [PMID:19396314]
13. Linda F Stein Gold.  (2009-08-26)  Calcitriol ointment: optimizing psoriasis therapy..  Journal of drugs in dermatology : JDD,  ((8 Suppl)): (s23-s27).  [PMID:19702033]
14. Laura Sánchez-Abella,Susana Fernández,Annemieke Verstuyf,Lieve Verlinden,Vicente Gotor,Miguel Ferrero.  (2009-09-11)  Synthesis, conformational analysis, and biological evaluation of 19-nor-vitamin D3 analogues with A-ring modifications..  Journal of medicinal chemistry,  52  ((19)): (6158-6162).  [PMID:19739672]
15. Laura L Sweeney,Alan O Malabanan,Harold Rosen.  (2010-01-12)  Decreased calcitriol requirement during pregnancy and lactation with a window of increased requirement immediately post partum..  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists,  16  ((3)): (459-462).  [PMID:20061285]
16. Melissa Kallas,Francis Green,Martin Hewison,Christopher White,Gregory Kline.  (2010-04-30)  Rare causes of calcitriol-mediated hypercalcemia: a case report and literature review..  The Journal of clinical endocrinology and metabolism,  95  ((7)): (3111-3117).  [PMID:20427501]
17. Pawel Grzywacz,Grazia Chiellini,Lori A Plum,Margaret Clagett-Dame,Hector F DeLuca.  (2010-11-26)  Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D₃ markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription..  Journal of medicinal chemistry,  53  ((24)): (8642-8649).  [PMID:21105677]
18. Yosuke Demizu,Takeo Takahashi,Fumiya Kaneko,Yukiko Sato,Haruhiro Okuda,Eiji Ochiai,Kyohei Horie,Ken-Ichiro Takagi,Shinji Kakuda,Midori Takimoto-Kamimura,Masaaki Kurihara.  (2011-09-06)  Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands..  Bioorganic & medicinal chemistry letters,  21  ((20)): (6104-6107).  [PMID:21889334]
19. Katarzyna Plonska-Ocypa,Izabela Sibilska,Rafal R Sicinski,Wanda Sicinska,Lori A Plum,Hector F DeLuca.  (2011-10-25)  13,13-Dimethyl-des-C,D analogues of (20S)-1α,25-dihydroxy-2-methylene-19-norvitamin D₃ (2MD): total synthesis, docking to the VDR, and biological evaluation..  Bioorganic & medicinal chemistry,  19  ((23)): (7205-7220).  [PMID:22018918]
20. Zhichao Liu,Qiang Shi,Don Ding,Reagan Kelly,Hong Fang,Weida Tong.  (2011-12-24)  Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps)..  PLoS computational biology,  ((12)): (e1002310-e1002310).  [PMID:22194678]
21. Upasana Banerjee,Manuka Ghosh,M Kyle Hadden.  (2012-01-10)  Evaluation of vitamin D3 A-ring analogues as Hedgehog pathway inhibitors..  Bioorganic & medicinal chemistry letters,  22  ((3)): (1330-1334).  [PMID:22226657]
22. Diego M Carballa,Flavia Zacconi,Urszula Kulesza,Antonio Mouriño,Mercedes Torneiro.  (2012-10-27)  Synthesis of 1α,25-dihydroxyvitamin D3 analogues with α-hydroxyalkyl substituents at C12..  The Journal of steroid biochemistry and molecular biology,  136  (34-38).  [PMID:23098691]
23. Nicola Napoli,Rocky Strollo,Dario Pitocco,Carla Bizzarri,Ernesto Maddaloni,Daria Maggi,Silvia Manfrini,Ann Schwartz,Paolo Pozzilli.  (2013-02-26)  Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes..  PloS one,  ((2)): (e56488-e56488).  [PMID:23437144]
24. Moira Cheung,Paul Roschger,Klaus Klaushofer,Louis-Nicolas Veilleux,Peter Roughley,Francis H Glorieux,Frank Rauch.  (2013-03-28)  Cortical and trabecular bone density in X-linked hypophosphatemic rickets..  The Journal of clinical endocrinology and metabolism,  98  ((5)): (E954-E961).  [PMID:23533226]
25. Steven R Feldman,Mary Mills,Thomas Brundage,William J Eastman.  (2013-04-03)  A multicenter, randomized, double-blind study of the efficacy and safety of calcipotriene foam, 0.005%, vs vehicle foam in the treatment of plaque-type psoriasis of the scalp..  Journal of drugs in dermatology : JDD,  12  ((3)): (300-306).  [PMID:23545912]
26. Michelle R Denburg,Anne K Tsampalieros,Ian H de Boer,Justine Shults,Heidi J Kalkwarf,Babette S Zemel,Debbie Foerster,David Stokes,Mary B Leonard.  (2013-04-03)  Mineral metabolism and cortical volumetric bone mineral density in childhood chronic kidney disease..  The Journal of clinical endocrinology and metabolism,  98  ((5)): (1930-1938).  [PMID:23547048]
27. Roger Bouillon,Liesbet Lieben,Chantal Mathieu,Annemieke Verstuyf,Geert Carmeliet.  (2013-07-19)  Vitamin D action: lessons from VDR and Cyp27b1 null mice..  Pediatric endocrinology reviews : PER,  10 Suppl 2  (354-366).  [PMID:23858619]
28. Douglas K Atchison,Pamela Harding,William H Beierwaltes.  (2013-08-09)  Vitamin D increases plasma renin activity independently of plasma Ca2+ via hypovolemia and β-adrenergic activity..  American journal of physiology. Renal physiology,  305  ((8)): (F1109-F1117).  [PMID:23926179]
29. Andrew G Turner,Maarten A Hanrath,Howard A Morris,Gerald J Atkins,Paul H Anderson.  (2013-10-16)  The local production of 1,25(OH)2D3 promotes osteoblast and osteocyte maturation..  The Journal of steroid biochemistry and molecular biology,  144 Pt A  (114-118).  [PMID:24125735]
30. Mehmet A Ozdemir,Kenan Yilmaz,Ummuhan Abdulrezzak,Sebahattin Muhtaroglu,Turkan Patiroglu,Musa Karakukcu,Ekrem Unal.  (2013-10-19)  The efficacy of vitamin K2 and calcitriol combination on thalassemic osteopathy..  Journal of pediatric hematology/oncology,  35  ((8)): (623-627).  [PMID:24136015]
31. Nina Karthaus,Annemiek B van Spriel,Maaike W G Looman,Shuo Chen,Lisanne M Spilgies,Liesbet Lieben,Geert Carmeliet,Marleen Ansems,Gosse J Adema.  (2013-12-20)  Vitamin D controls murine and human plasmacytoid dendritic cell function..  The Journal of investigative dermatology,  134  ((5)): (1255-1264).  [PMID:24352045]
32. Minjing Zou,Faisal S BinHumaid,Ali S Alzahrani,Essa Y Baitei,Futwan A Al-Mohanna,Brian F Meyer,Yufei Shi.  (2014-01-03)  Increased CYP24A1 expression is associated with BRAF(V600E) mutation and advanced stages in papillary thyroid carcinoma..  Clinical endocrinology,  81  ((1)): (109-116).  [PMID:24382015]
33. Subrata Deb,Mei Yieng Chin,Hans Adomat,Emma S Tomlinson Guns.  (2014-02-04)  Ginsenoside-mediated blockade of 1α,25-dihydroxyvitamin D3 inactivation in human liver and intestine in vitro..  The Journal of steroid biochemistry and molecular biology,  141  (94-103).  [PMID:24486455]
34. Chiyomi Hayashida,Junta Ito,Mai Nakayachi,Mari Okayasu,Yoko Ohyama,Yoshiyuki Hakeda,Takuya Sato.  (2014-03-13)  Osteocytes produce interferon-β as a negative regulator of osteoclastogenesis..  The Journal of biological chemistry,  289  ((16)): (11545-11555).  [PMID:24610813]
35. Nicole F Vélez,Nathaniel J Jellinek.  (2014-03-19)  Simple onycholysis: a diagnosis of exclusion..  Journal of the American Academy of Dermatology,  70  ((4)): (793-794).  [PMID:24629359]
36. Hoon-Soo Kim,Jung-Min Park,Moon-Bum Kim.  (2014-03-19)  Reply: To PMID 23957979..  Journal of the American Academy of Dermatology,  70  ((4)): (794-794).  [PMID:24629360]
37. Shunsuke Yamada,Masanori Tokumoto,Narihito Tatsumoto,Masatomo Taniguchi,Hideko Noguchi,Toshiaki Nakano,Kosuke Masutani,Hiroaki Ooboshi,Kazuhiko Tsuruya,Takanari Kitazono.  (2014-05-09)  Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia..  American journal of physiology. Renal physiology,  306  ((12)): (F1418-F1428).  [PMID:24808541]
38. G Drozdenko,T Scheel,G Heine,R Baumgrass,M Worm.  (2014-06-27)  Impaired T cell activation and cytokine production by calcitriol-primed human B cells..  Clinical and experimental immunology,  178  ((2)): (364-372).  [PMID:24965738]
39. Natalie A Twine,Li Chen,Chi N Pang,Marc R Wilkins,Moustapha Kassem.  (2014-07-02)  Identification of differentiation-stage specific markers that define the ex vivo osteoblastic phenotype..  Bone,  67  (23-32).  [PMID:24984278]
40. M Harishankar,K Afsal,V V Banurekha,N Meenakshi,P Selvaraj.  (2014-09-10)  1,25-Dihydroxy vitamin D3 downregulates pro-inflammatory cytokine response in pulmonary tuberculosis..  International immunopharmacology,  23  ((1)): (148-152).  [PMID:25194676]
41. Ming Kong,Longdong Zhu,Li Bai,Xiaohui Zhang,Yu Chen,Shuang Liu,Sujun Zheng,Stephen J Pandol,Yuan-Ping Han,Zhongping Duan.  (2014-09-13)  Vitamin D deficiency promotes nonalcoholic steatohepatitis through impaired enterohepatic circulation in animal model..  American journal of physiology. Gastrointestinal and liver physiology,  307  ((9)): (G883-G893).  [PMID:25214402]
42. Janice García-Quiroz,Rocío García-Becerra,Nancy Santos-Martínez,David Barrera,David Ordaz-Rosado,Euclides Avila,Ali Halhali,Octavio Villanueva,Maŕa J Ibarra-Sánchez,José Esparza-López,Armando Gamboa-Domínguez,Javier Camacho,Fernando Larrea,Lorenza Díaz.  (2014-10-05)  In vivo dual targeting of the oncogenic Ether-à-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors..  BMC cancer,  14  (745-745).  [PMID:25280486]
43. Tanya Seth-Vollenweider,Sneha Joshi,Puneet Dhawan,Said Sif,Sylvia Christakos.  (2014-10-18)  Novel mechanism of negative regulation of 1,25-dihydroxyvitamin D3-induced 25-hydroxyvitamin D3 24-hydroxylase (Cyp24a1) Transcription: epigenetic modification involving cross-talk between protein-arginine methyltransferase 5 and the SWI/SNF complex..  The Journal of biological chemistry,  289  ((49)): (33958-33970).  [PMID:25324546]
44. Patricia Martínez-Miguel,Jose Manuel Valdivielso,Diana Medrano-Andrés,Pablo Román-García,Jose Luis Cano-Peñalver,Manuel Rodríguez-Puyol,Diego Rodríguez-Puyol,Susana López-Ongil.  (2014-10-23)  The active form of vitamin D, calcitriol, induces a complex dual upregulation of endothelin and nitric oxide in cultured endothelial cells..  American journal of physiology. Endocrinology and metabolism,  307  ((12)): (E1085-E1096).  [PMID:25336523]
45. Haruka Sasaki,Kiyoko Watanabe,Toshizo Toyama,Yasunori Koyata,Nobushiro Hamada.  (2014-11-26)  Porphyromonas gulae 41-kDa fimbriae induced osteoclast differentiation and cytokine production..  The Journal of veterinary medical science,  77  ((3)): (265-271).  [PMID:25421499]
46. Won Seok Yang,Hyun Woo Kim,Joo Mi Lee,Nam Jeong Han,Mee Jeong Lee,Su-Kil Park.  (2015-01-04)  1,25-dihydroxyvitamin D3 causes ADAM10-dependent ectodomain shedding of tumor necrosis factor receptor 1 in vascular smooth muscle cells..  Molecular pharmacology,  87  ((3)): (533-542).  [PMID:25556238]
47. Hongrui Liu,Jian Cui,Wei Feng,Shengyu Lv,Juan Du,Jing Sun,Xiuchun Han,Zhenming Wang,Xiong Lu,Yimin,Kimimitsu Oda,Norio Amizuka,Minqi Li.  (2015-02-18)  Local administration of calcitriol positively influences bone remodeling and maturation during restoration of mandibular bone defects in rats..  Materials science & engineering. C, Materials for biological applications,  49  (14-24).  [PMID:25686922]
48. Hsiang-Hsi Hong,Tzung-Hai Yen,Adrienne Hong,Ting-An Chou.  (2015-03-11)  Association of vitamin D3 with alveolar bone regeneration in dogs..  Journal of cellular and molecular medicine,  19  ((6)): (1208-1217).  [PMID:25753943]
49. Chao Zhen,Xuedan Feng,Zhe Li,Yabo Wang,Bin Li,Lin Li,Moyuan Quan,Gaoning Wang,Li Guo.  (2015-03-17)  Suppression of murine experimental autoimmune encephalomyelitis development by 1,25-dihydroxyvitamin D3 with autophagy modulation..  Journal of neuroimmunology,  280  (1-7).  [PMID:25773147]
50. Youngtae Jeong,Srilatha Swami,Aruna V Krishnan,Jasmaine D Williams,Shanique Martin,Ronald L Horst,Megan A Albertelli,Brian J Feldman,David Feldman,Maximilian Diehn.  (2015-05-03)  Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D..  Molecular cancer therapeutics,  14  ((8)): (1951-1961).  [PMID:25934710]
51. Maria J Ramalho,Joana A Loureiro,Bárbara Gomes,Manuela F Frasco,Manuel A N Coelho,M Carmo Pereira.  (2015-07-23)  PLGA nanoparticles as a platform for vitamin D-based cancer therapy..  Beilstein journal of nanotechnology,  (1306-1318).  [PMID:26199834]
52. J M Wierzbicka,A Binek,T Ahrends,J D Nowacka,A Szydłowska,Ł Turczyk,T Wąsiewicz,P M Wierzbicki,R Sądej,R C Tuckey,A T Slominski,J Chybicki,K Adrych,Z Kmieć,M A Żmijewski.  (2015-08-12)  Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture..  International journal of oncology,  47  ((3)): (1084-1096).  [PMID:26260259]
53. Justin A Spanier,Faye E Nashold,Christopher G Mayne,Corwin D Nelson,Colleen E Hayes.  (2015-08-25)  Vitamin D and estrogen synergy in Vdr-expressing CD4(+) T cells is essential to induce Helios(+)FoxP3(+) T cells and prevent autoimmune demyelinating disease..  Journal of neuroimmunology,  286  (48-58).  [PMID:26298324]
54. Michelle A Josephson,L Philip Schumm,May Y Chiu,Cory Marshall,J Richard Thistlethwaite,Stuart M Sprague.  (2004-10-27)  Calcium and calcitriol prophylaxis attenuates posttransplant bone loss..  Transplantation,  78  ((8)): (1233-1236).  [PMID:15502727]
55. Justin R Sigmon,Brad A Yentzer,Steven R Feldman.  (2009-05-16)  Calcitriol ointment: a review of a topical vitamin D analog for psoriasis..  The Journal of dermatological treatment,  20  ((4)): (208-212).  [PMID:19444692]
56. .  (2009-09-10)  Calcitriol (Vectical) for mild to moderate plaque psoriasis..  The Medical letter on drugs and therapeutics,  51  ((1320)): (70-71).  [PMID:19738550]
57. Necmettin Akdeniz,Ibrahim Halil Yavuz,Serap Gunes Bilgili,Goknur Ozaydın Yavuz,Omer Calka.  (2013-02-28)  Comparison of efficacy of narrow band UVB therapies with UVB alone, in combination with calcipotriol, and with betamethasone and calcipotriol in vitiligo..  The Journal of dermatological treatment,  25  ((3)): (196-199).  [PMID:23441902]
58. R Volchenkov,M Karlsen,R Jonsson,S Appel.  (2013-02-28)  Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells..  Scandinavian journal of immunology,  77  ((4)): (246-254).  [PMID:23442246]
59. Hubert Maehr,Natacha Rochel,Hong Jin Lee,Nanjoo Suh,Milan R Uskokovic.  (2013-04-10)  Diastereotopic and deuterium effects in gemini..  Journal of medicinal chemistry,  56  ((10)): (3878-3888).  [PMID:23566225]
60. Yueh-Ting Lee,Hwee-Yeong Ng,Chien-Chun Kuo,Te-Chuan Chen,Chien-Shing Wu,Terry Ting-Yu Chiu,Wen-Chin Lee,Chien-Te Lee.  (2013-04-23)  Comparison between calcitriol and calcitriol plus low-dose cinacalcet for the treatment of moderate to severe secondary hyperparathyroidism in chronic dialysis patients..  Nutrients,  ((4)): (1336-1348).  [PMID:23603995]
61. Ning Ding,Ruth T Yu,Nanthakumar Subramaniam,Mara H Sherman,Caroline Wilson,Renuka Rao.  (2013-04-30)  A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response..  Cell,  153  ((3)): (601-613).  [PMID:23622244]
62. Kevin K Frick,John R Asplin,Nancy S Krieger,Christopher D Culbertson,Daniel M Asplin,David A Bushinsky.  (2013-08-09)  1,25(OH)₂D₃-enhanced hypercalciuria in genetic hypercalciuric stone-forming rats fed a low-calcium diet..  American journal of physiology. Renal physiology,  305  ((8)): (F1132-F1138).  [PMID:23926184]
63. Faye E Nashold,Corwin D Nelson,Lauren M Brown,Colleen E Hayes.  (2013-08-24)  One calcitriol dose transiently increases Helios+ FoxP3+ T cells and ameliorates autoimmune demyelinating disease..  Journal of neuroimmunology,  263  ((1-2)): (64-74).  [PMID:23968560]
64. Janice García-Quiroz,Mariana Rivas-Suárez,Rocío García-Becerra,David Barrera,Isela Martínez-Reza,David Ordaz-Rosado,Nancy Santos-Martinez,Octavio Villanueva,Clara L Santos-Cuevas,Euclides Avila,Armando Gamboa-Domínguez,Ali Halhali,Fernando Larrea,Lorenza Díaz.  (2013-10-15)  Calcitriol reduces thrombospondin-1 and increases vascular endothelial growth factor in breast cancer cells: implications for tumor angiogenesis..  The Journal of steroid biochemistry and molecular biology,  144 Pt A  (215-222).  [PMID:24120914]
65. Xuening Wang,Stella Pesakhov,Ashley Weng,Michael Kafka,Elzbieta Gocek,Mai Nguyen,Jonathan S Harrison,Michael Danilenko,George P Studzinski.  (2014-02-12)  ERK 5/MAPK pathway has a major role in 1α,25-(OH)2 vitamin D3-induced terminal differentiation of myeloid leukemia cells..  The Journal of steroid biochemistry and molecular biology,  144 Pt A  (223-227).  [PMID:24514755]
66. Raul A Chavez Valencia,David J Martino,Richard Saffery,Justine A Ellis.  (2014-02-15)  In vitro exposure of human blood mononuclear cells to active vitamin D does not induce substantial change to DNA methylation on a genome-scale..  The Journal of steroid biochemistry and molecular biology,  141  (144-149).  [PMID:24525112]
67. Matthew A Weeres,Kim Robien,Yong-Oon Ahn,Marie-Luise Neulen,Rachel Bergerson,Jeffery S Miller,Michael R Verneris.  (2014-08-26)  The effects of 1,25-dihydroxyvitamin D3 on in vitro human NK cell development from hematopoietic stem cells..  Journal of immunology (Baltimore, Md. : 1950),  193  ((7)): (3456-3462).  [PMID:25149465]
68. Maryam Doroudi,Marc C Plaisance,Barbara D Boyan,Zvi Schwartz.  (2014-09-30)  Membrane actions of 1α,25(OH)2D3 are mediated by Ca(2+)/calmodulin-dependent protein kinase II in bone and cartilage cells..  The Journal of steroid biochemistry and molecular biology,  145  (65-74).  [PMID:25263660]
69. Hideki Sugimoto,Kiyoko Watanabe,Toshizo Toyama,Shun-suke Takahashi,Shuta Sugiyama,Masaichi-Chang-il Lee,Nobushiro Hamada.  (2014-10-23)  Inhibitory effects of French pine bark extract, Pycnogenol®, on alveolar bone resorption and on the osteoclast differentiation..  Phytotherapy research : PTR,  29  ((2)): (251-259).  [PMID:25336411]
70. Tali Zitman-Gal,Janice Green,Zeev Korzets,Jacques Bernheim,Sydney Benchetrit.  (2015-03-07)  Kruppel-like factors in an endothelial and vascular smooth muscle cell coculture model: impact of a diabetic environment and vitamin D..  In vitro cellular & developmental biology. Animal,  51  ((5)): (470-478).  [PMID:25743914]
71. Ramiro José González-Duarte,Verna Cázares-Ordoñez,Sandra Romero-Córdoba,Lorenza Díaz,Víctor Ortíz,Julio Augusto Freyre-González,Alfredo Hidalgo-Miranda,Fernando Larrea,Euclides Avila.  (2015-06-26)  Calcitriol increases Dicer expression and modifies the microRNAs signature in SiHa cervical cancer cells..  Biochemistry and cell biology = Biochimie et biologie cellulaire,  93  ((4)): (376-384).  [PMID:26111345]

Solution Calculators