Potent, cell-permeable calpain inhibitor, a Ca 2+ -dependent protease. K i values are 34 and 52 nM for μ- and m-calpains, respectively. Demonstrates neuroprotective effects suggesting ability to cross the blood-brain barrier.
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of calpain 1;Inhibitor of cathepsin K
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Zhu M et al.. (2017) Calcium-binding protein S100A14 induces differentiation and suppresses metastasis in gastric cancer.. Cell Death Dis, 8 (7):(e2938). [PMID:28726786]
2.Wang Y et al.. (2018) Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia.. Oxid Med Cell Longev, 2018 (4612727). [PMID:30662583]
3.Ruoss S et al.. (2018) Inhibition of calpain delays early muscle atrophy after rotator cuff tendon release in sheep.. Physiol Rep, 6 (21):(e13833). [PMID:30393967]
4.Mans LA et al.. (2017) The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress.. Sci Rep, 7 (7327). [PMID:28779098]
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J2225229