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Cancer cell stemness inhibitor (Napabucasin) - ≥98%, high purity , CAS No.83280-65-3

  • Moligand™
  • ≥98%
Item Number
C275982
Grouped product items
SKUSizeAvailabilityPrice Qty
C275982-5mg
5mg
In stock
$75.90
C275982-25mg
25mg
In stock
$342.90
C275982-100mg
100mg
In stock
$489.90
C275982-500mg
500mg
In stock
$1,360.90
C275982-1g
1g
In stock
$1,795.90

Potent, broad spectrum stemness high-cancer cell inhibitor

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Pharmaceutical ingredients

Basic Description

SynonymsNapabucasin|83280-65-3|2-Acetylfuro-1,4-naphthoquinone|2-acetylnaphtho[2,3-b]furan-4,9-dione|BBI608|2-acetylbenzo[f][1]benzofuran-4,9-dione|BBI-608|Napabucasin (BBI608)|2-Acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione|2-Acetylfuranonaphthoquinone|Z1HHM49K7O|B
Specifications & Purity≥98%
SourceSynthetic
Storage TempStore at -20°C,Desiccated
Shipped InDry ice
GradeMoligand™
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Product Properties

ALogP2.3

Names and Identifiers

Pubchem Sid488196633
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488196633
IUPAC Name 2-acetylbenzo[f][1]benzofuran-4,9-dione
INCHI InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3
InChi Key DPHUWDIXHNQOSY-UHFFFAOYSA-N
Canonical SMILES CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O
Isomeric SMILES CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O
PubChem CID 10331844
Molecular Weight 240.21

Certificates

Certificate of Analysis(COA)

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11 results found

Lot NumberCertificate TypeDateItem
C2412026Certificate of AnalysisFeb 20, 2024 C275982
D2325463Certificate of AnalysisFeb 20, 2024 C275982
D2325464Certificate of AnalysisFeb 20, 2024 C275982
D2325468Certificate of AnalysisFeb 20, 2024 C275982
D2325470Certificate of AnalysisFeb 20, 2024 C275982
D2325471Certificate of AnalysisJan 31, 2024 C275982
D2325477Certificate of AnalysisJan 31, 2024 C275982
D2325481Certificate of AnalysisJan 31, 2024 C275982
D2325489Certificate of AnalysisJan 31, 2024 C275982
D2325490Certificate of AnalysisJan 31, 2024 C275982
D2325488Certificate of AnalysisMar 27, 2023 C275982

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Chemical and Physical Properties

SolubilitySoluble in DMSO
SensitivityHeat Sensitive
Melt Point(°C)226 °C

Related Documents

References

1. Bao N, Ou J, Xu M, Guan F, Shi W, Sun J, Chen L.  (2017)  Novel NO-releasing plumbagin derivatives: Design, synthesis and evaluation of antiproliferative activity..  Eur J Med Chem,  137  (3): (88-95).  [PMID:28558333]
2. Li Y, Rogoff HA, Keates S, Gao Y, Murikipudi S, Mikule K, Leggett D, Li W, Pardee AB, Li CJ.  (2015)  Suppression of cancer relapse and metastasis by inhibiting cancer stemness..  Proc Natl Acad Sci U S A,  112  (6): (1839-44).  [PMID:25605917]
3. Zhou Q, Peng C, Du F, Zhou L, Shi Y, Du Y, Liu D, Sun W, Zhang M, Chen G.  (2018)  Design, synthesis and activity of BBI608 derivatives targeting on stem cells..  Eur J Med Chem,  151  (3): (39-50).  [PMID:29604543]
4. Löcken H, Clamor C, Müller K.  (2018)  Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells..  J Nat Prod,  81  (7): (1636-1644).  [PMID:30003778]
5. Han D, Yu T, Dong N, Wang B, Sun F, Jiang D.  (2019)  Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells..  J Exp Clin Cancer Res,  38  (1): (289).  [PMID:31277685]
6. Chowdhury KH, Chowdhury MR, Mahmud S, Tareq AM, Hanif NB, Banu N, Reza ASMA, Emran TB, Simal-Gandara J.  (2020)  Drug Repurposing Approach against Novel Coronavirus Disease (COVID-19) through Virtual Screening Targeting SARS-CoV-2 Main Protease..  Biology (Basel),  10  (1): (589-97).  [PMID:33374717]
7. Hubbard JM, Grothey A.  (2017)  Napabucasin: An Update on the First-in-Class Cancer Stemness Inhibitor..  Drugs,  77  (10): (1091-1103).  [PMID:28573435]

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