Potent, broad spectrum stemness high-cancer cell inhibitor (IC 50 values are 500 - 1200 nM). Inhibits STAT3-driven gene transcription. Potently prevents self-renewal in cancer stem cells. Shows antineoplastic and antimetastatic effects in vivo.
Source
Synthetic
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Bao N, Ou J, Xu M, Guan F, Shi W, Sun J, Chen L. (2017) Novel NO-releasing plumbagin derivatives: Design, synthesis and evaluation of antiproliferative activity.. Eur J Med Chem, 137 (13):(88-95). [PMID:28558333][10.1021/op500134e]
2.Li Y, Rogoff HA, Keates S, Gao Y, Murikipudi S, Mikule K, Leggett D, Li W, Pardee AB, Li CJ. (2015) Suppression of cancer relapse and metastasis by inhibiting cancer stemness.. Proc Natl Acad Sci U S A, 112 (6):(1839-44). [PMID:25605917][10.1021/op500134e]
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4.Löcken H, Clamor C, Müller K. (2018) Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells.. J Nat Prod, 81 (7):(1636-1644). [PMID:30003778][10.1021/op500134e]
5.Han D, Yu T, Dong N, Wang B, Sun F, Jiang D. (2019) Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells.. J Exp Clin Cancer Res, 38 (1):(289). [PMID:31277685][10.1021/op500134e]
6.Chowdhury KH, Chowdhury MR, Mahmud S, Tareq AM, Hanif NB, Banu N, Reza ASMA, Emran TB, Simal-Gandara J. (2020) Drug Repurposing Approach against Novel Coronavirus Disease (COVID-19) through Virtual Screening Targeting SARS-CoV-2 Main Protease.. Biology (Basel), 10 (1):(1755-70). [PMID:33374717][10.3390/biology10010002]
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C2412026