Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C129307-200mg | 200mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $26.90 | |
C129307-250mg | 250mg | In stock | $27.90 | |
C129307-1g | 1g | In stock | $90.90 | |
C129307-5g | 5g | In stock | $409.90 | |
C129307-25g | 25g | In stock | $1,842.90 | |
C129307-100g | 100g | In stock | $6,633.90 |
Prodrug ofcandesartan(Cat. No. 4791), an AT1receptor antagonist
Synonyms | TCV116 | TCY 116 | CANDESARTAN CILEXETIL [VANDF] | GTPL8352 | NSC758697 | NSC-758697 | Parapres | Atacand | Racanda | (+-)-1-Hydroxyethyl 2-ethoxy-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-7-benzimidazolecarboxylate, cyclohexyl carbonate (ester) | 1H-Benzimi |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Prodrug of the angiotensin II receptor 1 (AT1) antagonistcandesartan, which exhibits antihypertensive effects in animal models. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Type-1 angiotensin II receptor antagonist |
Note | 250mg、200mg卖完停产,不再备货 |
Product Description | Candesartan Cilexetil is a specific nonpeptide Ang II receptor (ATR) antagonist and the prodrug of candesartan which is an ATR antagonist with an IC50 of 15 μg/kg |
ALogP | 7 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate |
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INCHI | InChI=1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38) |
InChi Key | GHOSNRCGJFBJIB-UHFFFAOYSA-N |
Canonical SMILES | CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC(C)OC(=O)OC6CCCCC6 |
Isomeric SMILES | CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC(C)OC(=O)OC6CCCCC6 |
WGK Germany | 3 |
RTECS | DD6672500 |
PubChem CID | 2540 |
Molecular Weight | 610.66 |
Reaxy-Rn | 7328188 |
PubChem CID | 2540 |
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ChEMBL Ligand | CHEMBL1014 |
ChEBI | CHEBI:3348 |
CAS Registry No. | 145040-37-5 |
PEP | candesartan cilexetil |
DrugCentral Ligand | 475 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H1913138 | Certificate of Analysis | Dec 05, 2024 | C129307 |
K2208549 | Certificate of Analysis | Aug 23, 2024 | C129307 |
K2208550 | Certificate of Analysis | Aug 23, 2024 | C129307 |
K2208551 | Certificate of Analysis | Aug 23, 2024 | C129307 |
K2208555 | Certificate of Analysis | Aug 23, 2024 | C129307 |
K2208556 | Certificate of Analysis | Aug 23, 2024 | C129307 |
E1528121 | Certificate of Analysis | Dec 08, 2022 | C129307 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 61.07, Max Conc. mM: 100 |
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Sensitivity | Heat sensitive |
Melt Point(°C) | 159 °C |
Pictogram(s) | GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H312:Harmful in contact with skin H400:Very toxic to aquatic life H332:Harmful if inhaled H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child H362:May cause harm to breast-fed children |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | DD6672500 |
Reaxy-Rn | 7328188 |
Merck Index | 1739 |
1. Qi Liang, Xiaoying Fu, Jianfeng Zhang, Jiaxue Hao, Gangjun Feng, Jing Wang, Qian Li, Faizan Ahmad, Xinfeng Zhao. (2020) Immobilized angiotensin II type I receptor: A powerful method of high throughput screening for antihypertensive compound identification through binding interaction analysis. JOURNAL OF CHROMATOGRAPHY A, 1620 (461003). [PMID:32156458] |
2. Zhang Lei, Zhang Shi-tao, Zhang Xiao-ping, Sun Jing, Wang Yong-sen, Liu Yue-long, Xue Miao-miao, Wang Zhi, Xing Shu, Ma Jun-feng, Li Wan-nan, Fu Xue-qi. (2013) Effect of Candesartan cilexetil as a sensitive and effective inhibitor of SHP-1 on insulin signaling pathway. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 29 (4): (730-734). [PMID:] |
1. Qi Liang, Xiaoying Fu, Jianfeng Zhang, Jiaxue Hao, Gangjun Feng, Jing Wang, Qian Li, Faizan Ahmad, Xinfeng Zhao. (2020) Immobilized angiotensin II type I receptor: A powerful method of high throughput screening for antihypertensive compound identification through binding interaction analysis. JOURNAL OF CHROMATOGRAPHY A, 1620 (461003). [PMID:32156458] |
2. Zhang Lei, Zhang Shi-tao, Zhang Xiao-ping, Sun Jing, Wang Yong-sen, Liu Yue-long, Xue Miao-miao, Wang Zhi, Xing Shu, Ma Jun-feng, Li Wan-nan, Fu Xue-qi. (2013) Effect of Candesartan cilexetil as a sensitive and effective inhibitor of SHP-1 on insulin signaling pathway. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 29 (4): (730-734). [PMID:] |