Canertinib dihydrochloride - 98% (HPLC), high purity , Receptor protein-tyrosine kinase erbB-4 inhibitor, CAS No.289499-45-2, Receptor protein-tyrosine kinase erbB-4 inhibitor

Item Number

C169301

• Synonyms: Q27280663 | A817177 | CI 1033 | CS-0263 | EN300-19659633 | Canertinib(dihydrochloride) | PD 183805 | AKOS015924656 | Canertinib HCl | N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride | AC-241
• Specifications & Purity: ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: Potent, irreversible pan-ErbB tyrosine kinase inhibitor (IC 50 values are 1.5 and 9 nM at EGFR and ErbB2 respectively). Orally active. Antitumor and radiation-sensitizing agent. Active in vivo and in vitro .
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Action Type: INHIBITOR
• Mechanism of action: Receptor protein-tyrosine kinase erbB-4 inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

CI-1033 is a potent, irreversible ATP binding site–directed pan-ErbB tyrosine kinase inhibitor with IC50 in the low nanomolar range for EGFR, HER2, and ErbB-4.