Captopril - ≥98%, high purity , Angiotensin-converting enzyme inhibitor, CAS No.62571-86-2, Angiotensin-converting enzyme inhibitor

Item Number

C129108

• Synonyms: Acepress | Captopril [USAN:USP:INN:BAN:JAN] | 1-((2S)-2-Methyl-3-sulfanylpropanoyl)-L-proline # | CHEBI:3380 | DTXSID1037197 | DTXCID9017197 | Tensoprel | Captopril,(S) | Captoprilum [INN-Latin] | Zapto | Tenosbon | 1-(3-Mercapto-2-methyl-1-oxopropyl)-L-p
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Potent ACE inhibitor (IC 50 = 21 nM). Reversible and competitive leukotriene A 4 hydrolase inhibitor (K i = 6 μM, leukotriene B4 formation). Vasodilatory and antihypertensive effects in vivo. Orally active.
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Angiotensin-converting enzyme inhibitor
• Note: Unstable; make up solutions fresh and use immediately. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Captopril is a reversible and competitive inhibitor of leukotriene A4 hydrolase (LTA4H; IC50 = 11μM). Captopril has been shown to be an inhibitor of angiotensin converting enzyme-1 (ACE1), but not ACE2 (IC50 = 22 nM). Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity. Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.
Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.