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Carbamazepine - 10mM in DMSO, high purity , CAS No.298-46-4(DMSO)

94 Citations
Item Number
C407797
Grouped product items
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C407797-1ml
1ml
Available within 4-8 weeks(?)
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$155.90
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Sodium Channel Inhibitors

Basic Description

Specifications & Purity10mM in DMSO
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Information

Carbamazepine Carbamazepine (Carbatrol, NSC 169864) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.
In vitro

Carbamazepine inhibits the binding of [3H]batrachotoxinin A 20-α-benzoate (BTX-B) to a receptor site of voltage-sensitive sodium channel with IC50 of 131 μM, to decrease the activation of sodium channel ion flux in rat brain synaptosomes. Carbamazepine reduces receptor affinity due to an increased rate of ligand dissociation from the receptor-ligand complex, without altering maximal binding capacity from the scatchard analysis of BTX-B binding to synaptosome, suggesting an indirect allosteric mechanism for anticonvulsant inhibition of BTX-B binding. Carbamazepine does not alter basal 125I-labeled scorpion toxin binding to synaptosomes in the absence of batrachotoxin, but when batrachotoxin (1.25 μM) added, Carbamazepine inhibits the batrachotoxin-dependent increase in scorpion toxin binding in a concentration-dependent manner with IC50 of 260 μM mediated at the alkaloid toxin binding site, none of which affects [3H]saxitoxin binding.

In vivo

Carbamazepine at 25 mg/kg significantly increases extracellular levels of striatal and hippocampal dopamine (DA), 3,4-dihydroxyphenylalanine (DOPA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in a dose dependent manner, while Carbamazepine at 50 mg/kg significantly decreases total levels of striatal DA and DOPA as well as hippocampal HVA, but has no effect on total levels of striatal DOPAC and HVA nor on hippocampal DA, DOPA and DOPAC. Intraperitoneal administration of Carbamazepine （~100 mg/kg）to rats produces significant increases in the cerebral cortical concentrations of neuroactive steroids and neuroactive steroids in plasma in a dose and time dependent maner with DHEA formed as a result of side chain cleavage of pregnenolone not affected.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Associated Targets(Human)

FZD8 Tbio Frizzled-8 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Canonical SMILES NC(=O)N1C2=C(C=CC=C2)C=CC3=C1C=CC=C3
Molecular Weight 236.27

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

Citations of This Product

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2. Kai Xuan, Taiguang Li, Yongmei Hao.  (2024)  Photo-Fenton synergistic degradation of carbamazepine and Cr (VI) over ZnIn2S4/Fe-POMs with inner-generate H2O2 and wide pH response.  JOURNAL OF ALLOYS AND COMPOUNDS,  976  (173005).  [PMID:10805725]
3. Xinhai Li, Ruixia Jin, Min Liu, Haiming Xu, Xiaoman Yu, Xinyi Xie.  (2024)  3D axial channels and interfacial oxygen vacancies cooperate for enhancing photo-Fenton performance of ZnO/BiOCl microsphere.  Surfaces and Interfaces,  44  (30): (103656).  [PMID:21238436]
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13. Gang Chu, Wangmin Wang, Yang Dou, Wenxiu Qin, Da Tian, Youbin Si.  (2023)  Contrasting impact of phosphorus dissolution on the sorption of bisphenol A and carbamazepine by phosphorus-rich chars.  CHEMICAL ENGINEERING JOURNAL,  475  (19): (146370).  [PMID:18957440]
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18. Yueling Yu, Jia Yang, Baogang Zhao, Xinfei Fan, Yuanlu Xu, Yanming Liu.  (2023)  Efficient sulfamethoxazole degradation via boosting nonradical-based peroxymonosulfate activation by biochar supported Co-Ni bimetal oxide.  Journal of Environmental Chemical Engineering,  11  (110903).  [PMID:]
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22. Yuanyuan Fu, Zhentao Li, Changjun Hu, Qiaoyan Li, Zilin Chen.  (2023)  In-situ immobilization of covalent organic frameworks as stationary phase for capillary electrochromatography.  JOURNAL OF CHROMATOGRAPHY A,  1705  (464205).  [PMID:37442070]
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31. He Yide, Zhang Yiqun, Zhou Wei, Freitas Rosa, Zhang Yunhai, Zhang Yongjun.  (2023)  Combined exposure of polystyrene microplastics and carbamazepine induced transgenerational effects on the reproduction of Daphnia magna.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  30  (25): (67596-67607).  [PMID:37115439]
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45. Jincheng Mu, Jinming Feng, Xinyang Wang, Baojun Liu.  (2023)  Oxygen vacancy boosting peroxymonosulfate activation over nanosheets assembled flower-like CoMoO4 for contaminant removal: Performance and activity enhancement mechanisms.  CHEMICAL ENGINEERING JOURNAL,  459  (141537).  [PMID:]
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50. Kun Ren, Ruijie Wang, Shinuo Fang, Shumeng Ren, Huiming Hua, Dongmei Wang, Yingni Pan, Xiaoqiu Liu.  (2023)  Effect of CYP3A inducer/inhibitor and licorice on hepatotoxicity and in vivo metabolism of main alkaloids of Euodiae Fructus based on UPLC-Q-Exactive-MS.  JOURNAL OF ETHNOPHARMACOLOGY,  303  (116005).  [PMID:36516906]
51. Wei Wang, Jinwen Zhang, Guotao Xiao, Xu Liu, Han Qu, Shuangxi Zhou.  (2023)  Preparation of magnetic porous graphene oxide by intercalating rigid molecule and subsequent magnetization for enhancing pharmaceuticals removal from water.  Materials Today Communications,  34  (105119).  [PMID:]
52. Peizhen Yang, Yuhan Long, Wenli Huang, Dongfang Liu.  (2023)  Single-atom copper embedded in two-dimensional MXene toward peroxymonosulfate activation to generate singlet oxygen with nearly 100% selectivity for enhanced Fenton-like reactions.  APPLIED CATALYSIS B-ENVIRONMENTAL,  324  (122245).  [PMID:]
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54. Chen An, Cai Peishan, Luo Minqian, Guo Minshan, Cai Ting.  (2023)  Melt Crystallization of Celecoxib-Carbamazepine Cocrystals with the Synchronized Release of Drugs.  PHARMACEUTICAL RESEARCH,  40  (2): (567-577).  [PMID:36348133]
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60. Xi GaoYang, Chen Shuxun, Zhang Xuhang, Xing Yu, He Zhengguang.  (2023)  Mechanism analysis of efficient degradation of carbamazepine by chalcopyrite-activated persulfate.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  30  (5): (13197-13209).  [PMID:36125685]
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64. Wu Yicheng, Zhou Zhuoyi, Ou Lihui, Yu Jian, Fu Haiyan, Yang Aili.  (2022)  The Toxicological Effects and Removal Characterization of Carbamazepine Using Chlorella vulgaris in Aqueous Media.  WATER AIR AND SOIL POLLUTION,  233  (9): (1-8).  [PMID:]
65. Chao Gong, Jinli Zhai, Xi Wang, Wenjie Zhu, Daoli Yang, Yongming Luo, Xiaoya Gao.  (2022)  Synergistic improving photo-Fenton and photo-catalytic degradation of carbamazepine over FeS2/Fe2O3/organic acid with H2O2 in-situ generation.  CHEMOSPHERE,  307  (136199).  [PMID:36030937]
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67. Mengxue Yang, Ruixian Wu, Shengshuai Cao, Yanwei Li, Sisi Huo, Wei Wang, Zhen Hu, Xing Xu.  (2023)  Versatile pathways for oxidating organics via peroxymonosulfate activation by different single atom catalysts confining with Fe–N4 or Cu–N4 sites.  CHEMICAL ENGINEERING JOURNAL,  451  (138606).  [PMID:]
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57. Chunyan Hu, Jianyi Li, Juncheng Ke, Jianjun Liang, Qiuliang Liu, Qiliang Wang, Wentao Huang.  (2023)  The preparation and removal performance of carbamazepine/oxcarbazepine double template magnetic molecularly imprinted polymers.  SEPARATION AND PURIFICATION TECHNOLOGY,  306  (122556).  [PMID:]
58. Wenjie Kuang, Zhang Yan, Jinxiu Chen, Xiaotang Ling, Wenxiao Zheng, Weijun Huang, Chunhua Feng.  (2023)  A Bipolar Membrane-Integrated Electrochlorination Process for Highly Efficient Ammonium Removal in Mature Landfill Leachate: The Importance of ClO• Generation.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,  57  (47): (18538–18549).  [PMID:36240017]
59. Guanhan Chen, Hongjie Wang, Wenyi Dong, Wenhui Ding, Feifei Wang, Zilong Zhao, Yuxiong Huang.  (2023)  The overlooked role of Co(OH)2 in Co3O4 activated PMS system: Suppression of Co2+ leaching and enhanced degradation performance of antibiotics with rGO.  SEPARATION AND PURIFICATION TECHNOLOGY,  304  (122203).  [PMID:]
60. Xi GaoYang, Chen Shuxun, Zhang Xuhang, Xing Yu, He Zhengguang.  (2023)  Mechanism analysis of efficient degradation of carbamazepine by chalcopyrite-activated persulfate.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  30  (5): (13197-13209).  [PMID:36125685]
61. Jingwei Yan, Lin Gong, Senyou Chai, Cong Guo, Wei Zhang, Hongyou Wan.  (2022)  Insights into a newly discovered mechanism for 1O2 formation in a chlorine ion-mediated sulfate radical-advanced oxidation process system for levofloxacin degradation in an aqueous solution.  SEPARATION AND PURIFICATION TECHNOLOGY,  302  (122016).  [PMID:]
62. Jun Zhang, Xi Quan, Fu Li, Chenxi Zhen, Linlin Yin, Wei Zuo, Yu Tian.  (2022)  A new β-cyclodextrin-encapsulated potassium ferrate composite (KFO@β-CD) for efficient removal of PPCPs from reclaimed water: Performance and degradation pathway.  Journal of Water Process Engineering,  49  (103072).  [PMID:]
63. Wenxue Xiong, Feng Hu, Ying Liu, Gang Nie, Ling Xiao.  (2022)  Core-shell FeMn@NG derived from cellulose supported Prussian blue analogs for peroxymonosulfate activation: Non-radical mechanism and ultra-low metal leaching.  Journal of Environmental Chemical Engineering,  10  (108523).  [PMID:]
64. Wu Yicheng, Zhou Zhuoyi, Ou Lihui, Yu Jian, Fu Haiyan, Yang Aili.  (2022)  The Toxicological Effects and Removal Characterization of Carbamazepine Using Chlorella vulgaris in Aqueous Media.  WATER AIR AND SOIL POLLUTION,  233  (9): (1-8).  [PMID:]
65. Chao Gong, Jinli Zhai, Xi Wang, Wenjie Zhu, Daoli Yang, Yongming Luo, Xiaoya Gao.  (2022)  Synergistic improving photo-Fenton and photo-catalytic degradation of carbamazepine over FeS2/Fe2O3/organic acid with H2O2 in-situ generation.  CHEMOSPHERE,  307  (136199).  [PMID:36030937]
66. Tong Liu, Yang Liu, Peng Zhou, Zhaokun Xiong, Heng Zhang, Chuanshu He, Ye Du, Gang Yao, Bo Lai.  (2022)  New insight of zero-valent iron activation S(IV) in absence of external hydrogenation ions for decomposing micropollutants: Two radical generation pathways depending on O2.  JOURNAL OF HAZARDOUS MATERIALS,  440  (129809).  [PMID:]
67. Mengxue Yang, Ruixian Wu, Shengshuai Cao, Yanwei Li, Sisi Huo, Wei Wang, Zhen Hu, Xing Xu.  (2023)  Versatile pathways for oxidating organics via peroxymonosulfate activation by different single atom catalysts confining with Fe–N4 or Cu–N4 sites.  CHEMICAL ENGINEERING JOURNAL,  451  (138606).  [PMID:]
68. Jun Zhao, Jingquan Wang, Erdeng Du, Yijie Ai, Jingjing Liu, Hongguang Guo.  (2022)  Water decontamination under high salinity using the TiO2 NT/PbO2–Cu electrochemical oxidation system: kinetics mechanism and DFT studies.  Environmental Science-Water Research & Technology,  8  (10): (2231-2244).  [PMID:]
69. Xianhu Long, Zhaokun Xiong, Rongfu Huang, Yahan Yu, Peng Zhou, Heng Zhang, Gang Yao, Bo Lai.  (2022)  Sustainable Fe(III)/Fe(II) cycles triggered by co-catalyst of weak electrical current in Fe(III)/peroxymonosulfate system: Collaboration of radical and non-radical mechanisms.  APPLIED CATALYSIS B-ENVIRONMENTAL,  317  (121716).  [PMID:]
70. Xing-Xing Wang, Yi-Li Lin, Tian-Yang Zhang, Zheng-Yu Dong, Zhen-Ning Luo, Chen-Yan Hu, Yu-Lin Tang, Bin Xu.  (2022)  Feasibility of UVC laser-activated persulfate with concentrated beam for micropollutant degradation in water.  SEPARATION AND PURIFICATION TECHNOLOGY,  299  (121598).  [PMID:]
71. Yang Huang, Xi Luo, Yini Du, Yu Fu, Xujing Guo, Changwu Zou, Yue Wu.  (2022)  The role of iron-doped g-C3N4 heterogeneous catalysts in Fenton-like process investigated by experiment and theoretical simulation.  CHEMICAL ENGINEERING JOURNAL,  446  (137252).  [PMID:]
72. Zhuoyi Zhou, Yicheng Wu, Yangyong Xu, Zejie Wang, Haiyan Fu, Yue Zheng.  (2022)  Carbamazepine degradation and genome sequencing of a novel exoelectrogen isolated from microbial fuel cells.  SCIENCE OF THE TOTAL ENVIRONMENT,  838  (156161).  [PMID:35609705]
73. Dongying Zhu, Zhujun Huang, Haiyan Wang, Qiujun Lu, Guihua Ruan, Chenxi Zhao, Fuyou Du.  (2022)  Sustainable and reusable electrospun g-C3N5/MIL-101(Fe)/poly(acrylonitrile-co-maleic acid) nanofibers for photocatalytic degradation of emerging pharmaceutical pollutants.  NEW JOURNAL OF CHEMISTRY,  46  (24): (11840-11850).  [PMID:]
74. Dongmei Ma, Jing Wang, Kun Feng, Bingfeng Liu, Guojun Xie, Defeng Xing.  (2022)  A green strategy from waste red mud to Fe0-based biochar for sulfadiazine treatment by peroxydisulfate activation.  CHEMICAL ENGINEERING JOURNAL,  446  (136944).  [PMID:]
75. Chengyu Chu, Nan Li, Tiefeng Xu, Feng Gao, Chenxiao Qi, Wangyang Lu, Wenxing Chen.  (2022)  Polymeric iron phthalocyanine/g-C3N4 composite catalyst by mechanical force enhanced stripping and recombination for solar-induced contaminant degradation and CO2 reduction.  APPLIED SURFACE SCIENCE,  592  (153308).  [PMID:]
76. Mengfan Luo, Heng Zhang, Peng Zhou, Jiali Peng, Ye Du, Zhaokun Xiong, Bo Lai.  (2022)  Graphite (GP) induced activation of ferrate(VI) for degradation of micropollutants: The crucial reduction role of carbonyl groups on GP surface.  JOURNAL OF HAZARDOUS MATERIALS,  434  (128827).  [PMID:35405605]
77. Nkoom Matthew, Lu Guanghua, Liu Jianchao.  (2022)  Chronic toxicity of diclofenac, carbamazepine and their mixture to Daphnia magna: a comparative two-generational study.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  29  (39): (58963-58979).  [PMID:35378650]
78. Jingxuan Li, Tiefeng Xu, Junting Gao, Zhendong Wang, Gangqiang Wang, Wenxing Chen, Wangyang Lu.  (2022)  Efficient peroxymonosulfate activation by N-rich pyridyl-iron phthalocyanine derivative for the elimination of pharmaceutical contaminants under solar irradiation.  CHEMOSPHERE,  299  (134464).  [PMID:35358552]
79. Chuangjian Su, Ruhong Li, Chaolin Li, Wenhui Wang.  (2022)  Piezo-promoted regeneration of Fe2+ boosts peroxydisulfate activation by Bi2Fe4O9 nanosheets.  APPLIED CATALYSIS B-ENVIRONMENTAL,  310  (121330).  [PMID:]
80. Xuedong Du, Pei Su, Wenyang Fu, Qizhan Zhang, Minghua Zhou.  (2022)  Heterogeneous photoelectro-Fenton catalyzed by FeCu@PC for efficient degradation of sulfamethazine.  ELECTROCHIMICA ACTA,  412  (140122).  [PMID:]
81. Hailan Qin, Jingyu Sun, Dongsheng Xia, Haiming Xu, Qilin Yu, Yi Zheng, Yintao Shi.  (2022)  Boosting nonradical process in BiOI/BiOCl heterostructure by interface oxygen vacancies.  CHEMICAL ENGINEERING JOURNAL,  435  (134847).  [PMID:]
82. Jun Li, Ge Gou, Hailing Zhao, Chao Liu, Naiwen Li, Longguo Li, Bo Tan, Bo Lai.  (2022)  Efficient peroxymonosulfate activation by CoFe2O4-CeO2 composite: Performance and catalytic mechanism.  CHEMICAL ENGINEERING JOURNAL,  435  (134840).  [PMID:]
83. Hui Su, Xudan Dou, Dandan Xu, Li Feng, Yongze Liu, Ziwen Du, Liqiu Zhang.  (2022)  Fe0-loaded superfine powdered activated carbon prepared by ball milling for synergistic adsorption and persulfate activation to remove aqueous carbamazepine.  CHEMOSPHERE,  293  (133665).  [PMID:35051510]
84. Li Li, Zhi Huang, Yanying Liu, Ziqi Zhu, Mingjun Xu, Wenxuan Wei, Qian Zhang, Junming Hong.  (2022)  Novel porous Mn-Fe nanocubes toward peroxymonosulfate activation via non-radical/radical pathways for emerging contaminants degradation.  APPLIED SURFACE SCIENCE,  581  (152390).  [PMID:]
85. Peizhen Yang, Songrong Li, Liang Xiaofu, An Xiaojing, Dongfang Liu, Wenli Huang.  (2022)  Singlet oxygen-dominated activation of peroxymonosulfate by CuO/MXene nanocomposites for efficient decontamination of carbamazepine under high salinity conditions: Performance and singlet oxygen evolution mechanism.  SEPARATION AND PURIFICATION TECHNOLOGY,  285  (120288).  [PMID:]
86. Guanhan Chen, Wenyi Dong, Hongjie Wang, Zilong Zhao, Feng Wang, Feifei Wang, Cesar Nieto-Delgado.  (2022)  Carbamazepine degradation by visible-light-driven photocatalyst Ag3PO4/GO: Mechanism and pathway.  Environmental Science and Ecotechnology,  9  (100143).  [PMID:36157857]
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90. Qipu Ma, Yuyao Zhang, Xiaoying Zhu, Baoliang Chen.  (2022)  Hollow multi-shelled Co3O4 as nanoreactors to activate peroxymonosulfate for highly effective degradation of Carbamazepine: A novel strategy to reduce nano-catalyst agglomeration.  JOURNAL OF HAZARDOUS MATERIALS,  427  (127890).  [PMID:34863576]
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94. Li Zhang, Xuerui Yang, Runsheng Zhou, Sen Lin, Lei Zhou.  (2022)  High-efficiency carbamazepine degradation using a Ni/Co-LDH as the peroxymonosulfate activator: Performance, mechanism and degradation pathway.  APPLIED SURFACE SCIENCE,  574  (151580).  [PMID:]

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