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C423663-1ml

1ml

Available within 4-8 weeks(?)

$116.90

Basic Description

Synonyms	FCCP \| 370-86-5 \| Carbonyl cyanide p-trifluoromethoxyphenylhydrazone \| Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone \| CHEBI:75458 \| 2-{2-[4-(Trifluoromethoxy)phenyl]hydrazono}malononitrile \| Propanedinitrile, ((4-(trifluoromethoxy)phenyl)hydrazono)- \| Propanedi
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Potent mitochondrial oxidative phosphorylation uncoupler (IC 50 = 20 nM). Disrupts ATP synthesis by transporting protons across mitochondrial inner membranes. Depolarises mitochondrial membrane potential.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

VDR Tclin Vitamin D receptor (26531 Activities)

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TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

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ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

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CCRF-CEM (65223 Activities)

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HL-60 (67320 Activities)

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MCF7 (126967 Activities)

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SH-SY5Y (11521 Activities)

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T47D (39041 Activities)

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HCT-116 (91556 Activities)

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MDA-MB-231 (73002 Activities)

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HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)

Discover Target: HSD17B10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

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Liver (3974 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRAP1 Tchem Heat shock protein 75 kDa, mitochondrial (274 Activities)

Discover Target: TRAP1

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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BLM Tchem Bloom syndrome protein (4248 Activities)

Discover Target: BLM

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)

Discover Target: RUNX1

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PRKAA2 Tchem AMP-activated protein kinase, AMPK (12273 Activities)

Discover Target: PRKAA2

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HIF1A Tchem Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (820 Activities)

Discover Target: HIF1A

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GM15850 (303 Activities)

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GM16216 (129 Activities)

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Hep 3B2 (2332 Activities)

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KOPN-8 (317 Activities)

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Associated Targets(non-human)

Cruzipain (33337 Activities)

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Leishmania infantum (5912 Activities)

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Leishmania amazonensis (3813 Activities)

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Leishmania braziliensis (1091 Activities)

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Leishmania donovani (89745 Activities)

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Leishmania major (2877 Activities)

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Trypanosoma cruzi (99888 Activities)

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Plasmodium berghei (192651 Activities)

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lef Anthrax lethal factor (7585 Activities)

Discover Target: lef

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GCN5 Histone acetyltransferase GCN5 (89 Activities)

Discover Target: GCN5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Impa1 Inositol monophosphatase 1 (16203 Activities)

Discover Target: Impa1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-[[4-(trifluoromethoxy)phenyl]hydrazinylidene]propanedinitrile
INCHI	InChI=1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H
InChi Key	BMZRVOVNUMQTIN-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1NN=C(C#N)C#N)OC(F)(F)F
Isomeric SMILES	C1=CC(=CC=C1NN=C(C#N)C#N)OC(F)(F)F
WGK Germany	3
RTECS	FG5775000
PubChem CID	3330
Molecular Weight	254.17
Beilstein	664446

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Melt Point(°C)	156 °C(dec.)

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H413:May cause long lasting harmful effects to aquatic life H317:May cause an allergic skin reaction
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3
RTECS	FG5775000

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Xu Zhang, Wei Xiong, Ling-Li Chen, Jia-Qiang Huang, Xin Gen Lei. (2020) Selenoprotein V protects against endoplasmic reticulum stress and oxidative injury induced by pro-oxidants. FREE RADICAL BIOLOGY AND MEDICINE, 160 (670). [PMID:32846216] [10.1016/j.freeradbiomed.2020.08.011]
2. Mengyun Peng, Xiao-Qiang Wang, Yu Zhang, Chu-Xin Li, Mingkang Zhang, Han Cheng, Xian-Zheng Zhang. (2019) Mitochondria-Targeting Thermosensitive Initiator with Enhanced Anticancer Efficiency. ACS Applied Bio Materials, 2 (10): (4656–4666). [PMID:35021424] [10.1021/acsabm.9b00739]

References

1. Xu Zhang, Wei Xiong, Ling-Li Chen, Jia-Qiang Huang, Xin Gen Lei. (2020) Selenoprotein V protects against endoplasmic reticulum stress and oxidative injury induced by pro-oxidants. FREE RADICAL BIOLOGY AND MEDICINE, 160 (670). [PMID:32846216] [10.1016/j.freeradbiomed.2020.08.011]
2. Mengyun Peng, Xiao-Qiang Wang, Yu Zhang, Chu-Xin Li, Mingkang Zhang, Han Cheng, Xian-Zheng Zhang. (2019) Mitochondria-Targeting Thermosensitive Initiator with Enhanced Anticancer Efficiency. ACS Applied Bio Materials, 2 (10): (4656–4666). [PMID:35021424] [10.1021/acsabm.9b00739]

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Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone - 10mM in DMSO, high purity , CAS No.370-86-5

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator