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Cariporide - ≥98%(HPLC), high purity , CAS No.159138-80-4

≥98%(HPLC)

CAS#: 159138-80-4
Formula: C₁₂H₁₇N₃O₃S
Molecular Weight: 283.35
PubChem CID: 151172

Item Number

C286810

Grouped product items
SKU	Size	Availability	Price
C286810-5mg	5mg	In stock	$101.90
C286810-10mg	10mg	In stock	$143.90
C286810-25mg	25mg	In stock	$324.90
C286810-50mg	50mg	In stock	$556.90
C286810-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$908.90

Selective NHE1 inhibitor; cardioprotective and antitumor

Basic Description

Synonyms	Cariporide \| 159138-80-4 \| Hoe-642 \| N-(Diaminomethylene)-4-isopropyl-3-(methylsulfonyl)benzamide \| Cariporide [INN] \| N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide \| N-(diaminomethylidene)-3-methylsulfonyl-4-propan-2-ylbenzamide \| Benzamide, N-(am
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective Na+/H+exchanger isoform 1 (NHE1) inhibitor (IC50values are 0.05, 3 and 1000μM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosisin vitro. Reduces cardiac arrhythmiain vivo. Also promotes apoptosis in cance
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

SLC9A1 Tchem Sodium/hydrogen exchanger 1 (9 Activities)

Discover Target: SLC9A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC9A3 Tclin Sodium/hydrogen exchanger 3 (483 Activities)

Discover Target: SLC9A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC9A5 Tchem Sodium/hydrogen exchanger 5 (22 Activities)

Discover Target: SLC9A5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

SLC9A1 Sodium/hydrogen exchanger 1 (3 Activities)

Discover Target: SLC9A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC9A2 Sodium/hydrogen exchanger 2 (9 Activities)

Discover Target: SLC9A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NHE1 Sodium/hydrogen exchanger (7 Activities)

Discover Target: NHE1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Heart (171 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Atrium (63 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-(diaminomethylidene)-3-methylsulfonyl-4-propan-2-ylbenzamide
INCHI	InChI=1S/C12H17N3O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18/h4-7H,1-3H3,(H4,13,14,15,16)
InChi Key	IWXNYAIICFKCTM-UHFFFAOYSA-N
Canonical SMILES	CC(C)C1=C(C=C(C=C1)C(=O)N=C(N)N)S(=O)(=O)C
Isomeric SMILES	CC(C)C1=C(C=C(C=C1)C(=O)N=C(N)N)S(=O)(=O)C
PubChem CID	151172
Molecular Weight	283.35

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
C2215378	Certificate of Analysis	Feb 15, 2022	C286810
C2215384	Certificate of Analysis	Feb 15, 2022	C286810
C2215387	Certificate of Analysis	Feb 15, 2022	C286810
C2215398	Certificate of Analysis	Feb 15, 2022	C286810
C2215410	Certificate of Analysis	Feb 15, 2022	C286810

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