Cariporide - 10mM in DMSO, high purity , CAS No.159138-80-4

  • 10mM in DMSO
Item Number
C421903
Grouped product items
SKUSizeAvailabilityPrice Qty
C421903-1ml
1ml
Available within 4-8 weeks(?)
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$196.90

Selective NHE1 inhibitor; cardioprotective and antitumor

Basic Description

SynonymsN-carbamimidoyl-3-methanesulfonyl-4-(propan-2-yl)benzamide | AC-14535 | 3-methylsulfonyl-4-i-propylbenzoylguanidine | NCGC00247951-01 | AC-31727 | BENZAMIDE, N-(DIAMINOMETHYLENE)-4-(1-METHYLETHYL)-3-(METHYLSULFONYL)- | AKOS015854493 | DS-11823 | s5814 | B
Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsSelective Na+/H+exchanger isoform 1 (NHE1) inhibitor (IC50values are 0.05, 3 and 1000μM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosisin vitro. Reduces cardiac arrhythmiain vivo. Also promotes apoptosis in cance
Storage TempStore at -80°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

SLC9A1 Tchem Sodium/hydrogen exchanger 1 (9 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC9A3 Tclin Sodium/hydrogen exchanger 3 (483 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC9A5 Tchem Sodium/hydrogen exchanger 5 (22 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

SLC9A1 Sodium/hydrogen exchanger 1 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC9A2 Sodium/hydrogen exchanger 2 (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NHE1 Sodium/hydrogen exchanger (7 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Heart (171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Atrium (63 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name N-(diaminomethylidene)-3-methylsulfonyl-4-propan-2-ylbenzamide
INCHI InChI=1S/C12H17N3O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18/h4-7H,1-3H3,(H4,13,14,15,16)
InChi Key IWXNYAIICFKCTM-UHFFFAOYSA-N
Canonical SMILES CC(C)C1=C(C=C(C=C1)C(=O)N=C(N)N)S(=O)(=O)C
Isomeric SMILES CC(C)C1=C(C=C(C=C1)C(=O)N=C(N)N)S(=O)(=O)C
PubChem CID 151172
Molecular Weight 283.35

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