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Cariporide - 10mM in DMSO, high purity , CAS No.159138-80-4
Selective NHE1 inhibitor; cardioprotective and antitumor
Basic Description
| Synonyms | Cariporide | 159138-80-4 | Hoe-642 | N-(Diaminomethylene)-4-isopropyl-3-(methylsulfonyl)benzamide | Cariporide [INN] | N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide | N-(diaminomethylidene)-3-methylsulfonyl-4-propan-2-ylbenzamide | Benzamide, N-(am |
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| Specifications & Purity | 10mM in DMSO |
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| Biochemical and Physiological Mechanisms | Selective Na+/H+exchanger isoform 1 (NHE1) inhibitor (IC50values are 0.05, 3 and 1000μM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosisin vitro. Reduces cardiac arrhythmiain vivo. Also promotes apoptosis in cance |
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| Storage Temp | Store at -80°C |
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| Shipped In | Ice chest + Ice pads |
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Associated Targets(Human)
Associated Targets(non-human)
Names and Identifiers
| IUPAC Name | N-(diaminomethylidene)-3-methylsulfonyl-4-propan-2-ylbenzamide |
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| INCHI | InChI=1S/C12H17N3O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18/h4-7H,1-3H3,(H4,13,14,15,16) |
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| InChi Key | IWXNYAIICFKCTM-UHFFFAOYSA-N |
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| Canonical SMILES | CC(C)C1=C(C=C(C=C1)C(=O)N=C(N)N)S(=O)(=O)C |
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| Isomeric SMILES | CC(C)C1=C(C=C(C=C1)C(=O)N=C(N)N)S(=O)(=O)C |
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| PubChem CID | 151172 |
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| Molecular Weight | 283.35 |
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