Carmofur - >98.0%(HPLC), high purity , CAS No.61422-45-5

Item Number

C153374

• Synonyms: carmofur | 61422-45-5 | HCFU | Mifurol | 1-Hexylcarbamoyl-5-fluorouracil | 5-fluoro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide | 1(2H)-Pyrimidinecarboxamide, 5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo- | NSC-758963 | 5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carb
• Specifications & Purity: ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: Potent acid ceramidase inhibitor (IC 50 = 29 nM). Antimetabolite agent. cytostatic pyrimidine analogue derivative of fluorouracil ( Asc 2387 ) . Shows antitumor effects in vivo. Orally active.
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Product Application:

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine.