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Carvacrol - 99%, high purity , CAS No.499-75-2, Channel blocker of TRPM7;Activator of TRPV3

46 Citations
Item Number
C107162
Grouped product items
SKUSizeAvailabilityPrice Qty
C107162-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$9.90
C107162-100g
100g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$19.90
C107162-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$79.90
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Anti-infection Fungal Neuronal Signaling Notch Stem Cell/Wnt TRPM7 Channel blocker TRPV3 Activator

Basic Description

Synonyms2-methyl-5-propan-2-ylphenol | 2-methyl-5-propan-2-yl-phenol | AKOS000120828 | F8889-1978 | MB00118 | Oxycymol | 9B1J4V995Q | C09840 | CARVACROL [MI] | FS-4199 | Isothymol (=2-Isopropyl-4-methyl phenol) | NCGC00256001-01 | AC-2688 | CARVACROL [INCI] | Cym
Specifications & PurityMoligand™, ≥99%
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
GradeMoligand™
Action TypeACTIVATOR, CHANNEL BLOCKER
Mechanism of actionChannel blocker of TRPM7;Activator of TRPV3
Product Description

Carvacrol is one of the key constituents of basil and thyme essential oils. It is one of the compounds that may be responsible for antioxidant activities of these oils.

Carvacrol is one of the key constituents of basil and thyme essential oils. It is one of the compounds that may be responsible for antioxidant activities of these oils.
Carvacrol, is present in the essential oil of various plants and also taquila. It inhibits the growth of several bacteria strains, e.g. Escherichia coli[, and due to its good taste can be used as a food additive. It also activates PPAR and suppresses COX-2 inflammation.

Associated Targets(Human)

TRPM7 Tchem Transient receptor potential cation channel subfamily M member 7 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TYR Tclin Tyrosinase (717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A4 Tbio UDP-glucuronosyltransferase 1A4 (288 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT2B15 Tbio UDP-glucuronosyltransferase 2B15 (172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 (448 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A6 Tbio UDP-glucuronosyltransferase 1-6 (221 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A8 Tbio UDP-glucuronosyltransferase 1-8 (233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A9 Tbio UDP-glucuronosyltransferase 1-9 (343 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A10 Tbio UDP-glucuronosyltransferase 1-10 (257 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT2A1 UDP-glucuronosyltransferase 2A1 (59 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Streptococcus pneumoniae (31063 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pyricularia grisea (1253 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus agalactiae (1777 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus pyogenes (16140 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nakaseomyces glabratus (9108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida parapsilosis (8521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida tropicalis (8381 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fusarium oxysporum (3998 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Meloidogyne incognita (862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Musca domestica (713 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Botrytis cinerea (4183 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rdl GABA receptor subunit (76 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
norA Quinolone resistance protein norA (2171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida dubliniensis (570 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Colletotrichum fragariae (147 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Colletotrichum gloeosporioides (560 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Debaryomyces hansenii (127 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Drechslera (102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rhizoctonia solani (2251 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Tribolium castaneum (596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sciatic nerve (18 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Meloidogyne javanica (98 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Colletotrichum acutatum (300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-methyl-5-propan-2-ylphenol
INCHI InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3
InChi Key RECUKUPTGUEGMW-UHFFFAOYSA-N
Canonical SMILES CC1=C(C=C(C=C1)C(C)C)O
Isomeric SMILES CC1=C(C=C(C=C1)C(C)C)O
WGK Germany 3
RTECS FI1225000
PubChem CID 10364
UN Number 3265
Molecular Weight 150.22
Beilstein 1860514
Reaxy-Rn 1860514

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot NumberCertificate TypeDateItem
K2407212Certificate of AnalysisNov 19, 2024 C107162
K2427382Certificate of AnalysisNov 15, 2024 C107162
K2427384Certificate of AnalysisNov 15, 2024 C107162
L2410027Certificate of AnalysisNov 15, 2024 C107162
G2415336Certificate of AnalysisAug 10, 2024 C107162
K2125815Certificate of AnalysisAug 21, 2023 C107162
G2108174Certificate of AnalysisApr 13, 2023 C107162
D23111146Certificate of AnalysisJun 07, 2022 C107162
F2223269Certificate of AnalysisJun 07, 2022 C107162
F2223270Certificate of AnalysisJun 07, 2022 C107162
F2223314Certificate of AnalysisJun 07, 2022 C107162
G2326072Certificate of AnalysisJun 07, 2022 C107162
H2309608Certificate of AnalysisJun 07, 2022 C107162
L2314058Certificate of AnalysisJun 07, 2022 C107162
C2330337Certificate of AnalysisApr 30, 2021 C107162

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Chemical and Physical Properties

SolubilitySoluble in 60% ethanol (0.25 ml/ml), alcohol, and ether. Insoluble in water.
SensitivityAir sensitive;Moisture sensitive
Refractive Index1.522
Flash Point(°F)222.8 °F
Flash Point(°C)85℃
Boil Point(°C)238°C
Melt Point(°C)3°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H302:Harmful if swallowed

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

WGK Germany 3
RTECS FI1225000
Reaxy-Rn 1860514
Merck Index 1872

Related Documents

 SDS

 Specification Sheet

Citations of This Product

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2. Tiantian Min, Yujie Lei, Chuanxiang Cheng, Yuwan Luo, Yushan Zhang, Jin Yue.  (2024)  Highly efficient anchoring of γ-cyclodextrin-MOFs on chitosan/cellulose film by in situ growth to enhance encapsulation and controlled release of carvacrol.  FOOD HYDROCOLLOIDS,  150  (109633).  [PMID:] [10.1016/j.foodhyd.2023.109633]
3. Siyuan Xie, He Si, Shenfei Zhang, Ru Zhou, Yuyan Xue, Shijie Wang, Shiqiang Wang, Yizhong Duan, Junfeng Niu, Zhezhi Wang.  (2023)  Efficacy and Potential Mechanism of Essential Oils of Three Labiatae Plants against the Pathogenic Fungi of Root Rot Disease in Atractylodes chinensis.  Horticulturae,  9  (10): (1136).  [PMID:11169732] [10.3390/horticulturae9101136]
4. Ke Hu, Rongyu Li, Feixu Mo, Yi Ding, Aiai Zhou, Xue Guo, Ruotong Li, Min Li, Minggui Ou, Ming Li.  (2023)  Natural product osthole can significantly disrupt cell wall integrity and dynamic balance of Fusarium oxysporum.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,  196  (24): (105623).  [PMID:37945232] [10.1016/j.pestbp.2023.105623]
5. Liushen Lu, Junwei Wang, Ting Qin, Kai Chen, Jun Xie, Bingwen Xi.  (2023)  Carvacrol Inhibits Quorum Sensing in Opportunistic Bacterium Aeromonas hydrophila.  Microorganisms,  11  (8): (2027).  [PMID:37630587] [10.3390/microorganisms11082027]
6. Jiafu Liu, Yanzheng Lin, Yuting Huang, Luyang Liu, Xueming Cai, Jintian Lin, Benshui Shu.  (2023)  The effects of carvacrol on development and gene expression profiles in Spodoptera frugiperda.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,  195  (105539).  [PMID:37666589] [10.1016/j.pestbp.2023.105539]
7. Wu Wang, Tingting Li, Jing Chen, Yingwang Ye.  (2023)  Inhibition of Salmonella Enteritidis by Essential Oil Components and the Effect of Storage on the Quality of Chicken.  Foods,  12  (13): (2560).  [PMID:37444298] [10.3390/foods12132560]
8. Jiyao Zhang, Alkassoumi Hassane Hamadou, Chao Chen, Bin Xu.  (2023)  Entrapment of carvacrol in zein-trehalolipid nanoparticles via pH-driven method and antisolvent co-precipitation: Influence of loading approaches on formation, stability, and release.  LWT-FOOD SCIENCE AND TECHNOLOGY,  183  (114916).  [PMID:] [10.1016/j.lwt.2023.114916]
9. Guoyu Wei, Wei Zhao, Anlong Hu, Mingjian Ren, Yunxiao Huang, Huayang Xu.  (2023)  Identification of a New Pathogenic fungi Causing Sorghum Leaf Spot Disease and Its Management Using Natural Product and Microorganisms.  Microorganisms,  11  (6): (1431).  [PMID:37374932] [10.3390/microorganisms11061431]
10. Jianbing Wu, Wenjun Guo, Yongfeng Wang, Jian Liu, Heng Wang, Zhaozhu Zheng, Xiaoqin Wang, David L. Kaplan.  (2023)  Stabilization and Sustained Release of Fragrances Using Silk-PEG Microspheres.  ACS Biomaterials Science & Engineering,  9  (6): (3335–3347).  [PMID:37144723] [10.1021/acsbiomaterials.3c00064]
11. Wen Song, Zhiyuan Yin, Xinyu Lu, Danyu Shen, Daolong Dou.  (2023)  Plant secondary metabolite citral interferes with Phytophthora capsici virulence by manipulating the expression of effector genes.  MOLECULAR PLANT PATHOLOGY,      [PMID:37092279] [10.1111/mpp.13340]
12. Zhaolun Li, Hongyan Wu, Jianan Liu, Hongshun Hao, Jingran Bi, Hongman Hou, Gongliang Zhang.  (2023)  Synergistic effects of benzyl isothiocyanate and resveratrol against Listeria monocytogenes and their application in chicken meat preservation.  FOOD CHEMISTRY,  419  (135984).  [PMID:37044056] [10.1016/j.foodchem.2023.135984]
13. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long.  (2023)  Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms.  PEST MANAGEMENT SCIENCE,      [PMID:36864770] [10.1002/ps.7431]
14. Yongshi Li, Peng Shan, Fuyou Yu, Hui Li, Lincai Peng.  (2023)  Fabrication and characterization of waste fish scale-derived gelatin/sodium alginate/carvacrol loaded ZIF-8 nanoparticles composite films with sustained antibacterial activity for active food packaging.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  230  (123192).  [PMID:36634795] [10.1016/j.ijbiomac.2023.123192]
15. Junwei Wang, Ting Qin, Kai Chen, Liangkun Pan, Jun Xie, Bingwen Xi.  (2022)  Antimicrobial and Antivirulence Activities of Carvacrol against Pathogenic Aeromonas hydrophila.  Microorganisms,  10  (11): (2170).  [PMID:36363761] [10.3390/microorganisms10112170]
16. Xiaohan Ge, Xueying Huang, Liping Zhou, Yi Wang.  (2022)  Essential oil-loaded antimicrobial and antioxidant zein/poly(lactic acid) film as active food packaging.  Food Packaging and Shelf Life,  34  (100977).  [PMID:] [10.1016/j.fpsl.2022.100977]
17. Jishuai Sun, Yishen Cheng, Tuo Zhang, Jiachen Zang.  (2022)  Microencapsulation of Carvacrol by Complex Coacervation of Walnut Meal Protein Isolate and Gum Arabic: Preparation, Characterization and Bio-Functional Activity.  Foods,  11  (21): (3382).  [PMID:36359995] [10.3390/foods11213382]
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20. Jinhao Zhao, Minmin Liang, Zhongyan Wang, Yanyan Zhao, Jingli Cheng, Yongjun Du.  (2022)  Evaluation and optimization of blends for attracting Trichogramma dendrolimi based on semiochemicals mediating tritrophic interactions in the orchard habitat.  BIOLOGICAL CONTROL,  173  (104998).  [PMID:] [10.1016/j.biocontrol.2022.104998]
21. Qi Guo, Shuai Li, Gengan Du, Hong Chen, Xiaohai Yan, Shuaidan Chang, Tianli Yue, Yahong Yuan.  (2022)  Formulation and characterization of microcapsules encapsulating carvacrol using complex coacervation crosslinked with tannic acid.  LWT-FOOD SCIENCE AND TECHNOLOGY,  165  (113683).  [PMID:] [10.1016/j.lwt.2022.113683]
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29. Junfeng Cheng, Hualin Wang, Feng Xiao, Li Xia, Linlin Li, Shaotong Jiang.  (2021)  Functional effectiveness of double essential oils@yam starch/microcrystalline cellulose as active antibacterial packaging.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  186  (873).  [PMID:34293359] [10.1016/j.ijbiomac.2021.07.094]
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31. Tonghui Liu, Chuqi Feng, Zhaofeng Li, Zhengbiao Gu, Xiaofeng Ban, Yan Hong, Li Cheng, Caiming Li.  (2021)  Efficient formation of carvacrol inclusion complexes during β-cyclodextrin glycosyltransferase-catalyzed cyclodextrin synthesis.  FOOD CONTROL,  130  (108296).  [PMID:] [10.1016/j.foodcont.2021.108296]
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35. Xiaopeng Lu, Hua Weng, Chao Li, Jun He, Xing Zhang, Zhiqing Ma.  (2020)  Efficacy of essential oil from Mosla chinensis Maxim. cv. Jiangxiangru and its three main components against insect pests.  INDUSTRIAL CROPS AND PRODUCTS,  147  (112237).  [PMID:] [10.1016/j.indcrop.2020.112237]
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38. Junbo He, Shuangshuang Huang, Xiaotao Sun, Lijuan Han, Chao Chang, Weinong Zhang, Qixin Zhong.  (2019)  Carvacrol Loaded Solid Lipid Nanoparticles of Propylene Glycol Monopalmitate and Glyceryl Monostearate: Preparation, Characterization, and Synergistic Antimicrobial Activity.  Nanomaterials,  9  (8): (1162).  [PMID:31416170] [10.3390/nano9081162]
39. Hao Dong, Jiapeng He, Kaijun Xiao, Chao Li.  (2019)  Temperature-sensitive polyurethane (TSPU) film incorporated with carvacrol and cinnamyl aldehyde: antimicrobial activity, sustained release kinetics and potential use as food packaging for Cantonese-style moon cake.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  55  (1): (293-302).  [PMID:] [10.1111/ijfs.14276]
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