Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C123267-1g | 1g | In stock | $89.90 | |
C123267-5g | 5g | In stock | $274.90 | |
C123267-25g | 25g | In stock | $823.90 |
Potent β and α 1 adrenoceptor antagonist
Synonyms | Spectrum3_001182 | Artist (TN) | HMS3655O14 | Kredex | carvedilol | HMS2089B09 | NSC-758694 | 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol | C07AG02 | Carvedilolum | SCHEMBL13287211 | BM-14190 | BM-14-190 | CARVEDILOL [JAN] | DT |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Potent β and α 1 adrenoceptor antagonist (K i values are 0.81, 0.96 and 2.2 nM for β 1 , β 2 and α 1 adrenoceptors, respectively). Shows antihypertensive, antioxidant, antiapoptotic, anti-inflammatory and antifibrotic properties. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Carvedilol is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure. |
ALogP | 4.2 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol |
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INCHI | InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3 |
InChi Key | OGHNVEJMJSYVRP-UHFFFAOYSA-N |
Canonical SMILES | COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O |
Isomeric SMILES | COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O |
WGK Germany | 3 |
RTECS | UA8670000 |
PubChem CID | 2585 |
Molecular Weight | 406.47 |
Reaxy-Rn | 1514452 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H2209168 | Certificate of Analysis | Jul 22, 2022 | C123267 |
H2209302 | Certificate of Analysis | Jul 22, 2022 | C123267 |
D1820095 | Certificate of Analysis | Feb 23, 2022 | C123267 |
D1820096 | Certificate of Analysis | Feb 23, 2022 | C123267 |
B2210439 | Certificate of Analysis | Dec 21, 2021 | C123267 |
B2210467 | Certificate of Analysis | Dec 21, 2021 | C123267 |
B2210481 | Certificate of Analysis | Dec 21, 2021 | C123267 |
I2406050 | Certificate of Analysis | Dec 21, 2021 | C123267 |
Solubility | Soluble in DMSO (>25 mg/ml), ethanol (10 mg/ml), methanol (33.8 mg/ml), phosphate buffer (pH 4) (0.43 mg/ml) at 37 °C, water (partly miscible), chloroform, methylene chloride, and ethyl ether (slightly soluble). Insoluble in isopropanol. |
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Melt Point(°C) | 115.0°C-119.0°C |
Pictogram(s) | GHS09 |
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Hazard Statements | H411:Toxic to aquatic life with long lasting effects |
Precautionary Statements | P273:Avoid release to the environment. P501:Dispose of contents/container to ... P391:Collect spillage. |
WGK Germany | 3 |
RTECS | UA8670000 |
Reaxy-Rn | 1514452 |
1. Hongqiu Zhou, Li Yang, Changsuo Wang, Zhiqiang Li, Zhen Ouyang, Mangting Shan, Jun Gu, Yuan Wei. (2019) CYP2D1 Gene Knockout Reduces the Metabolism and Efficacy of Venlafaxine in Rats. DRUG METABOLISM AND DISPOSITION, 47 (12): (1425-1432). [PMID:31658948] [10.1124/dmd.119.088526] |
2. Xue Ren, Man He, Beibei Chen, Bin Hu. (2020) Magnetic porous organic polymers for extraction of cardiovascular drugs in human urine samples followed by HPLC-UV. Analytical Methods, 12 (2): (141-148). [PMID:] [10.1039/C9AY02041A] |
3. Wenying Fan, Man He, Linna You, Xuewei Zhu, Beibei Chen, Bin Hu. (2016) Water-compatible graphene oxide/molecularly imprinted polymer coated stir bar sorptive extraction of propranolol from urine samples followed by high performance liquid chromatography-ultraviolet detection. JOURNAL OF CHROMATOGRAPHY A, 1443 (1). [PMID:26993782] [10.1016/j.chroma.2016.03.017] |
1. Hongqiu Zhou, Li Yang, Changsuo Wang, Zhiqiang Li, Zhen Ouyang, Mangting Shan, Jun Gu, Yuan Wei. (2019) CYP2D1 Gene Knockout Reduces the Metabolism and Efficacy of Venlafaxine in Rats. DRUG METABOLISM AND DISPOSITION, 47 (12): (1425-1432). [PMID:31658948] [10.1124/dmd.119.088526] |
2. Xue Ren, Man He, Beibei Chen, Bin Hu. (2020) Magnetic porous organic polymers for extraction of cardiovascular drugs in human urine samples followed by HPLC-UV. Analytical Methods, 12 (2): (141-148). [PMID:] [10.1039/C9AY02041A] |
3. Wenying Fan, Man He, Linna You, Xuewei Zhu, Beibei Chen, Bin Hu. (2016) Water-compatible graphene oxide/molecularly imprinted polymer coated stir bar sorptive extraction of propranolol from urine samples followed by high performance liquid chromatography-ultraviolet detection. JOURNAL OF CHROMATOGRAPHY A, 1443 (1). [PMID:26993782] [10.1016/j.chroma.2016.03.017] |