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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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C343787-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $64.90 | |
C343787-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $256.90 | |
C343787-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $484.90 |
an inhibitor of caspase-1, caspase-4, and caspase-5
Synonyms | Ac-Yvad-cho | Caspase-1 Inhibitor I | 143313-51-3 | L-709049 | NVF6UYC3CM | Acetyl-tyrosyl-valyl-alanyl-aspartal | CHEMBL37630 | Ac-Tyr-Val-Ala-Asp-H | Ycad-CHO | Ac-Tyr-Val-Ala-Asp-Aldehyde | acetyl-Tyr-Val-Ala-Asp-aldehyde | N-acetyl-Tyr-Val-Ala-Asp-aldehyde | Acetyl-tyrosyl-v |
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Specifications & Purity | ≥95% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Aqueous solutions should not be stored more than 1 day. |
Product Description | Caspase-1 Inhibitor I (Ac-YVAD-CHO, also designated L-709049) is a potent, specific, reversible inhibitor of caspase-1 (K|i|= 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)|2|tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Ac-YVAD-CHO has been shown to strongly inhibit anti-APO-1 induced apoptosis in L929-APO-1 cells. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis.|Additional caspase-1 inhibitors available:|caspase-1 inhibitor |caspase-1 inhibitor VI |Caspase-1 Inhibitor II |Caspase-1 Inhibitor IV |
pKa | pKa: 4.20 (Predicted) |
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Ki Data | recombinant caspase-1: Ki= 200 pM (human); Caspase-1: Ki= 9 nM (mouse) |
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IUPAC Name | (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxobutanoic acid |
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INCHI | InChI=1S/C23H32N4O8/c1-12(2)20(23(35)24-13(3)21(33)26-16(11-28)10-19(31)32)27-22(34)18(25-14(4)29)9-15-5-7-17(30)8-6-15/h5-8,11-13,16,18,20,30H,9-10H2,1-4H3,(H,24,35)(H,25,29)(H,26,33)(H,27,34)(H,31,32)/t13-,16-,18-,20-/m0/s1 |
InChi Key | LPIARALSGDVZEP-SJVNDZIOSA-N |
Canonical SMILES | CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)O)C=O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C |
Isomeric SMILES | C[C@@H](C(=O)N[C@@H](CC(=O)O)C=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)C |
WGK Germany | 3 |
PubChem CID | 5311139 |
Molecular Weight | 492.52 |
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Solubility | Soluble in DMSO (5 mg/ml), water (5 mg/ml) at 25° C, ethanol (~30 mg/ml), DMF (~30 mg/ml), and PBS(pH 7.2) (~5 mg/ml). |
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Refractive Index | n20D1.55 (Predicted) |
Boil Point(°C) | ~937.75° C at 760 mmHg (Predicted) |
Melt Point(°C) | 349.84° C (Predicted) |
WGK Germany | 3 |
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