Caspase-1 inhibitor I - ≥95%, high purity , CAS No.143313-51-3

  • ≥95%
Item Number
C343787
Grouped product items
SKUSizeAvailabilityPrice Qty
C343787-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$64.90
C343787-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$256.90
C343787-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$484.90

an inhibitor of caspase-1, caspase-4, and caspase-5

Basic Description

SynonymsN-Ac-Tyr-Val-Ala-Asp-CHO | (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-4-oxobutanoic acid | HY-120019 | SCHEMBL4349143 | acetyl-Tyr-Val-Ala-Asp-aldehyde | AKOS040744457 | CS-0068866 | MFCD002371
Specifications & Purity≥95%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteAqueous solutions should not be stored more than 1 day.
Product Description

Caspase-1 Inhibitor I (Ac-YVAD-CHO, also designated L-709049) is a potent, specific, reversible inhibitor of caspase-1 (K|i|= 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)|2|tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Ac-YVAD-CHO has been shown to strongly inhibit anti-APO-1 induced apoptosis in L929-APO-1 cells. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis.|Additional caspase-1 inhibitors available:|caspase-1 inhibitor |caspase-1 inhibitor VI |Caspase-1 Inhibitor II |Caspase-1 Inhibitor IV

Product Properties

pKapKa: 4.20 (Predicted)
Ki Datarecombinant caspase-1: Ki= 200 pM (human); Caspase-1: Ki= 9 nM (mouse)

Associated Targets(Human)

CASP3 Tchem Caspase-3 (3632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CASP1 Tchem Caspase-1 (6235 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PBMC (10003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IL1B Tclin Interleukin-1 beta (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
INCHI InChI=1S/C23H32N4O8/c1-12(2)20(23(35)24-13(3)21(33)26-16(11-28)10-19(31)32)27-22(34)18(25-14(4)29)9-15-5-7-17(30)8-6-15/h5-8,11-13,16,18,20,30H,9-10H2,1-4H3,(H,24,35)(H,25,29)(H,26,33)(H,27,34)(H,31,32)/t13-,16-,18-,20-/m0/s1
InChi Key LPIARALSGDVZEP-SJVNDZIOSA-N
Canonical SMILES CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)O)C=O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C
Isomeric SMILES C[C@@H](C(=O)N[C@@H](CC(=O)O)C=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)C
WGK Germany 3
PubChem CID 5311139
Molecular Weight 492.52

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO (5 mg/ml), water (5 mg/ml) at 25° C, ethanol (~30 mg/ml), DMF (~30 mg/ml), and PBS(pH 7.2) (~5 mg/ml).
Refractive Indexn20D1.55 (Predicted)
Boil Point(°C)~937.75° C at 760 mmHg (Predicted)
Melt Point(°C)349.84° C (Predicted)

Safety and Hazards(GHS)

WGK Germany 3

Related Documents

Solution Calculators