Basic Description

Synonyms	(+)-Catechin Hydrate \| Catechin hydrate \| 225937-10-0 \| (+)-catechin monohydrate \| 88191-48-4 \| (2R,3S)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol hydrate \| (+)-Cyanidol-3 \| CHEBI:58994 \| (2R-trans)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol monohydr
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	An antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological systems. For example, at physiological pH catechin suppressed DNA strand breaks by hydroxyl radicals. It has also been s
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	(+)-Catechin monohydrate is an antioxidant flavonoid that is a free radical scavenger. Research shows that it is relatively nontoxic to cells at high doses. (+)-Catechin can stop ultraviolet B induced human keratinocyte death through the inhibition of JNK phosphorylation. Literature indicates that it may have Ca2+ antagonistic activity. (+)-Catechin monohydrate is an inhibitor of Cox-1. An antioxidant flavonoid that is a free radical scavenger

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLB Tchem DNA polymerase beta (23632 Activities)

Discover Target: POLB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

Discover Target: GAA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALPG Tchem Alkaline phosphatase placental-like (1197 Activities)

Discover Target: ALPG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALPL Tchem Alkaline phosphatase, tissue-nonspecific isozyme (1551 Activities)

Discover Target: ALPL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

Discover Target: GLS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAN Tchem GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 (21853 Activities)

Discover Target: RAN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Iap Intestinal alkaline phosphatase (419 Activities)

Discover Target: Iap

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dnaB Replicative DNA helicase (15 Activities)

Discover Target: dnaB

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BCHE Cholinesterase (8742 Activities)

Discover Target: BCHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Large T antigen (1457 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

recA Protein RecA (2211 Activities)

Discover Target: recA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol;hydrate
INCHI	InChI=1S/C15H14O6.H2O/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7;/h1-5,13,15-20H,6H2;1H2/t13-,15+;/m0./s1
InChi Key	OFUMQWOJBVNKLR-NQQJLSKUSA-N
Canonical SMILES	C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O.O
Isomeric SMILES	C1[C@@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O.O
WGK Germany	3
RTECS	DJ3450000
Alternate CAS	154-23-4
PubChem CID	107957
Molecular Weight	290.27
Beilstein	3595244
Reaxy-Rn	92761

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Melt Point(°C)	96°C(lit.)

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	DJ3450000
Reaxy-Rn	92761

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Zijian Liang, Pangzhen Zhang, Wen Ma, Xin-An Zeng, Zhongxiang Fang. (2024) Physicochemical properties, antioxidant activities and comprehensive phenolic profiles of tea-macerated Chardonnay wine and model wine. FOOD CHEMISTRY, 436 (4): (137748). [PMID:37862991]
2. Tong Jiang, Hong Wang, Peihua Xu, Yifan Yao, Yilong Ma, Zhaojun Wei, Xiangli Niu, Yafang Shang, Dong Zhao. (2023) Effect of grape seed proanthocyanidin on the structural and physicochemical properties of bread during bread fermentation stage. Current Research in Food Science, 7 (100559). [PMID:37600464]
3. Mao-Ling Luo, Hua Chen, Guo-Ying Chen, Shengpeng Wang, Yitao Wang, Feng-Qing Yang. (2023) Preparation of Alcohol Dehydrogenase–Zinc Phosphate Hybrid Nanoflowers through Biomimetic Mineralization and Its Application in the Inhibitor Screening. MOLECULES, 28 (14): (5429). [PMID:37513303]
4. Chengxiang Chu, Xianfeng Wang, Yuanyi Deng, Yi Ma, Chengyue Zou, Mei Yang, Huibo Luo, Danqun Huo, Changjun Hou. (2023) Discrimination of Chinese green tea according to tea polyphenols using fluorescence sensor array based on Tb (III) and Eu (III) doped Zr (IV) metal–organic frameworks. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 292 (122380). [PMID:36736046]
5. Shuai Zhang, Qin Ma, Lihong Dong, Xuchao Jia, Lei Liu, Fei Huang, Guang Liu, Zhida Sun, Jianwei Chi, Mingwei Zhang, Ruifen Zhang. (2022) Phenolic profiles and bioactivities of different milling fractions of rice bran from black rice. FOOD CHEMISTRY, 378 (132035). [PMID:35042109]
6. Yirong Xia, Xintong Wang, Hechen Sun, Ximing Huang. (2021) Proton-coupled electron transfer of catechin in tea wine: the enhanced mechanism of anti-oxidative capacity. RSC Advances, 11 (63): (39985-39993). [PMID:35494161]
7. Murtaza Ali, Jun-Hu Cheng, Da-Wen Sun. (2020) Effects of dielectric barrier discharge cold plasma treatments on degradation of anilazine fungicide and quality of tomato (Lycopersicon esculentum Mill) juice. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 56 (1): (69-75). [PMID:]
8. Mengting Wang, Jinyuan Shi, Lei Wang, Yaqin Hu, Xingqian Ye, Donghong Liu, Jianchu Chen. (2018) Inhibitory kinetics and mechanism of flavonoids from lotus (Nelumbo nucifera Gaertn.) leaf against pancreatic α-amylase. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 120 (2589). [PMID:30195612]
9. Juan Xu, Hongpo Zhou, Kun Li, Jinju Ma, Wenwen Zhang, Lanxiang Liu, Yanlin Sun, Hong Zhang, Kai Li. (2018) Multi-scale pectin/polyphenol beads for non-fouling fluorescence tracking on soft matter under water. CARBOHYDRATE POLYMERS, 199 (186). [PMID:30143119]
10. Rana Muhammad Aadil, Xin-An Zeng, Zhong Han, Amna Sahar, Anees Ahmed Khalil, Ubaid Ur Rahman, Muneeb Khan, Tariq Mehmood. (2017) Combined effects of pulsed electric field and ultrasound on bioactive compounds and microbial quality of grapefruit juice. JOURNAL OF FOOD PROCESSING AND PRESERVATION, 42 (2): (e13507). [PMID:]
11. Dongwei Wei, Weizhi Huo, Guangmeng Li, Qiuling Xie, Yanbin Jiang. (2018) The combined effects of lysozyme and ascorbic acid on microstructure and properties of zein-based films. CHINESE JOURNAL OF CHEMICAL ENGINEERING, 26 (648). [PMID:]
12. Lite Yang, Bingjie Xu, Huili Ye, Faqiong Zhao, Baizhao Zeng. (2017) A novel quercetin electrochemical sensor based on molecularly imprinted poly(para-aminobenzoic acid) on 3D Pd nanoparticles-porous graphene-carbon nanotubes composite. SENSORS AND ACTUATORS B-CHEMICAL, 251 (601). [PMID:]
13. Lele Zhang, Minglei Yang, Junlan Gao, Shan Jin, Zhengyan Wu, Lifang Wu, Xin Zhang. (2016) Seasonal variation and gender pattern of phenolic and flavonoid contents in Pistacia chinensis Bunge inflorescences and leaves. JOURNAL OF PLANT PHYSIOLOGY, 191 (36). [PMID:26717010]
14. Rana Muhammad Aadil, Xin-An Zeng, Amjad Ali, Feng Zeng, Muhammad Adil Farooq, Zhong Han, Saud Khalid, Saqib Jabbar. (2015) Influence of different pulsed electric field strengths on the quality of the grapefruit juice. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 50 (10): (2290-2296). [PMID:]
15. Rana Muhammad Aadil, Xin-An Zeng, Man-Sheng Wang, Zhi-Wei Liu, Zhong Han, Zhi-Hong Zhang, Jing Hong, Saqib Jabbar. (2015) A potential of ultrasound on minerals, micro-organisms, phenolic compounds and colouring pigments of grapefruit juice. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 50 (5): (1144-1150). [PMID:]
16. Rana Muhammad Aadil, Xin-An Zeng, Zhi-Hong Zhang, Man-Sheng Wang, Zhong Han, Hong Jing, Saqib Jabbar. (2015) Thermosonication: a potential technique that influences the quality of grapefruit juice. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 50 (5): (1275-1282). [PMID:]
17. Yurong Ma, Huihua Huang. (2014) Characterisation and comparison of phenols, flavonoids and isoflavones of soymilk and their correlations with antioxidant activity. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 49 (10): (2290-2298). [PMID:]
18. Mengying He, Ting Wu, Siyi Pan, Xiaoyun Xu. (2014) Antimicrobial mechanism of flavonoids against Escherichia coli ATCC 25922 by model membrane study. APPLIED SURFACE SCIENCE, 305 (515). [PMID:]
19. Huijie Zhang, Mingqin Kang, Hanqi Zhang, Yong Yu. (2014) Matrix solid phase dispersion extraction for determination of flavonoids in the flower of Chrysanthemum morifolium Ramat. by capillary zone electrophoresis. Analytical Methods, 6 (3): (766-773). [PMID:]

References

1. Zijian Liang, Pangzhen Zhang, Wen Ma, Xin-An Zeng, Zhongxiang Fang. (2024) Physicochemical properties, antioxidant activities and comprehensive phenolic profiles of tea-macerated Chardonnay wine and model wine. FOOD CHEMISTRY, 436 (4): (137748). [PMID:37862991]
2. Tong Jiang, Hong Wang, Peihua Xu, Yifan Yao, Yilong Ma, Zhaojun Wei, Xiangli Niu, Yafang Shang, Dong Zhao. (2023) Effect of grape seed proanthocyanidin on the structural and physicochemical properties of bread during bread fermentation stage. Current Research in Food Science, 7 (100559). [PMID:37600464]
3. Mao-Ling Luo, Hua Chen, Guo-Ying Chen, Shengpeng Wang, Yitao Wang, Feng-Qing Yang. (2023) Preparation of Alcohol Dehydrogenase–Zinc Phosphate Hybrid Nanoflowers through Biomimetic Mineralization and Its Application in the Inhibitor Screening. MOLECULES, 28 (14): (5429). [PMID:37513303]
4. Chengxiang Chu, Xianfeng Wang, Yuanyi Deng, Yi Ma, Chengyue Zou, Mei Yang, Huibo Luo, Danqun Huo, Changjun Hou. (2023) Discrimination of Chinese green tea according to tea polyphenols using fluorescence sensor array based on Tb (III) and Eu (III) doped Zr (IV) metal–organic frameworks. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 292 (122380). [PMID:36736046]
5. Shuai Zhang, Qin Ma, Lihong Dong, Xuchao Jia, Lei Liu, Fei Huang, Guang Liu, Zhida Sun, Jianwei Chi, Mingwei Zhang, Ruifen Zhang. (2022) Phenolic profiles and bioactivities of different milling fractions of rice bran from black rice. FOOD CHEMISTRY, 378 (132035). [PMID:35042109]
6. Yirong Xia, Xintong Wang, Hechen Sun, Ximing Huang. (2021) Proton-coupled electron transfer of catechin in tea wine: the enhanced mechanism of anti-oxidative capacity. RSC Advances, 11 (63): (39985-39993). [PMID:35494161]
7. Murtaza Ali, Jun-Hu Cheng, Da-Wen Sun. (2020) Effects of dielectric barrier discharge cold plasma treatments on degradation of anilazine fungicide and quality of tomato (Lycopersicon esculentum Mill) juice. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 56 (1): (69-75). [PMID:]
8. Mengting Wang, Jinyuan Shi, Lei Wang, Yaqin Hu, Xingqian Ye, Donghong Liu, Jianchu Chen. (2018) Inhibitory kinetics and mechanism of flavonoids from lotus (Nelumbo nucifera Gaertn.) leaf against pancreatic α-amylase. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 120 (2589). [PMID:30195612]
9. Juan Xu, Hongpo Zhou, Kun Li, Jinju Ma, Wenwen Zhang, Lanxiang Liu, Yanlin Sun, Hong Zhang, Kai Li. (2018) Multi-scale pectin/polyphenol beads for non-fouling fluorescence tracking on soft matter under water. CARBOHYDRATE POLYMERS, 199 (186). [PMID:30143119]
10. Rana Muhammad Aadil, Xin-An Zeng, Zhong Han, Amna Sahar, Anees Ahmed Khalil, Ubaid Ur Rahman, Muneeb Khan, Tariq Mehmood. (2017) Combined effects of pulsed electric field and ultrasound on bioactive compounds and microbial quality of grapefruit juice. JOURNAL OF FOOD PROCESSING AND PRESERVATION, 42 (2): (e13507). [PMID:]
11. Dongwei Wei, Weizhi Huo, Guangmeng Li, Qiuling Xie, Yanbin Jiang. (2018) The combined effects of lysozyme and ascorbic acid on microstructure and properties of zein-based films. CHINESE JOURNAL OF CHEMICAL ENGINEERING, 26 (648). [PMID:]
12. Lite Yang, Bingjie Xu, Huili Ye, Faqiong Zhao, Baizhao Zeng. (2017) A novel quercetin electrochemical sensor based on molecularly imprinted poly(para-aminobenzoic acid) on 3D Pd nanoparticles-porous graphene-carbon nanotubes composite. SENSORS AND ACTUATORS B-CHEMICAL, 251 (601). [PMID:]
13. Lele Zhang, Minglei Yang, Junlan Gao, Shan Jin, Zhengyan Wu, Lifang Wu, Xin Zhang. (2016) Seasonal variation and gender pattern of phenolic and flavonoid contents in Pistacia chinensis Bunge inflorescences and leaves. JOURNAL OF PLANT PHYSIOLOGY, 191 (36). [PMID:26717010]
14. Rana Muhammad Aadil, Xin-An Zeng, Amjad Ali, Feng Zeng, Muhammad Adil Farooq, Zhong Han, Saud Khalid, Saqib Jabbar. (2015) Influence of different pulsed electric field strengths on the quality of the grapefruit juice. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 50 (10): (2290-2296). [PMID:]
15. Rana Muhammad Aadil, Xin-An Zeng, Man-Sheng Wang, Zhi-Wei Liu, Zhong Han, Zhi-Hong Zhang, Jing Hong, Saqib Jabbar. (2015) A potential of ultrasound on minerals, micro-organisms, phenolic compounds and colouring pigments of grapefruit juice. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 50 (5): (1144-1150). [PMID:]
16. Rana Muhammad Aadil, Xin-An Zeng, Zhi-Hong Zhang, Man-Sheng Wang, Zhong Han, Hong Jing, Saqib Jabbar. (2015) Thermosonication: a potential technique that influences the quality of grapefruit juice. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 50 (5): (1275-1282). [PMID:]
17. Yurong Ma, Huihua Huang. (2014) Characterisation and comparison of phenols, flavonoids and isoflavones of soymilk and their correlations with antioxidant activity. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 49 (10): (2290-2298). [PMID:]
18. Mengying He, Ting Wu, Siyi Pan, Xiaoyun Xu. (2014) Antimicrobial mechanism of flavonoids against Escherichia coli ATCC 25922 by model membrane study. APPLIED SURFACE SCIENCE, 305 (515). [PMID:]
19. Huijie Zhang, Mingqin Kang, Hanqi Zhang, Yong Yu. (2014) Matrix solid phase dispersion extraction for determination of flavonoids in the flower of Chrysanthemum morifolium Ramat. by capillary zone electrophoresis. Analytical Methods, 6 (3): (766-773). [PMID:]

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(+)-Catechin Hydrate - 10mM in DMSO, high purity , CAS No.225937-10-0