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CAY10571 , CAS No.152121-46-5
a cell permeable, reversible, and ATP-competitive sulfone analog of the p38 MAP kinase inhibitor
Basic Description Synonyms KBio2_005580 | KBioSS_000444 | KBioGR_000444 | BDBM50284506 | IDI1_002147 | BiomolKI2_000013 | BMK1-B3 | 4-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)-1H-imidazole | 3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine | CCG-100607 | Bio2_000872 | KBio Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description CAY10571 is a cell permeable, reversible, and ATP-competitive sulfone analog of the p38 MAP kinase inhibitor SB 203580. Potently inhibits p38 kinase (IC50 = 30 nM) and inhibits IL-1 production in human monocytes (IC50 = 200 nM).
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 4-[4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-imidazol-5-yl]pyridine INCHI InChI=1S/C21H16FN3O2S/c1-28(26,27)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) InChi Key XEOVWJYINDYNSM-UHFFFAOYSA-N Canonical SMILES CS(=O)(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F Isomeric SMILES CS(=O)(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F PubChem CID 6610350 Molecular Weight 393.43
Chemical and Physical Properties Solubility Soluble in DMSO (200 mg/ml), DMF (~50 mg/ml), and 1:3 DMF:PBS (pH 7.2) (~0.25 mg/ml). Refractive Index n20D1.62 (Predicted) Boil Point(°C) ~635.4° C at 760 mmHg (Predicted) Melt Point(°C) 284.55° C (Predicted)
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