CAY10594 , CAS No.1130067-34-3

Item Number

C331610

Grouped product items
SKU	Size	Availability	Price	Qty
C331610-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$93.90
C331610-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$197.90

a PC-PLD2 inhibitor which also prevents the invasive migration of breast cancer cells

Basic Description

Synonyms	BCP30751 \| SR-01000928454 \| BDBM50278167 \| SCHEMBL10311310 \| AKOS028114472 \| N-[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]naphthalene-2-carboxamide \| AS-55973 \| CHEBI:95023 \| EX-A3212 \| Q27166784 \| HMS3648I04 \| N-(2-(4-Oxo-1-phenyl-1,3,8-tr
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	CAY10594 is a Phospholipase D (PLD) inhibitor. PLD is an enzyme that cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD (PLD1 and PLD2) have been identified, with multiple splice variants of each. Although the two isoforms share functional and structural features, they are regulated differently and apparently serve distinct biological roles. CAY10594 is a potent PC-PLD2 inhibitor\|in vitro\|(IC\|50\|= 140 nM). It also inhibits PC-PLD1 at higher concentrations (IC\|50\|= 5.1 μM). CAY10594 strongly inhibits the invasive migration of breast cancer cells in transwell assays, suggesting that PLD might be a useful target in blocking tumor cell invasion.

Associated Targets(Human)

PLD1 Tchem Phospholipase D1 (3 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLD2 Tchem Phospholipase D2 (4 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLD1 Tchem Phospholipase D1 (469 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLD2 Tchem Phospholipase D2 (437 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]naphthalene-2-carboxamide
INCHI	InChI=1S/C26H28N4O2/c31-24(22-11-10-20-6-4-5-7-21(20)18-22)27-14-17-29-15-12-26(13-16-29)25(32)28-19-30(26)23-8-2-1-3-9-23/h1-11,18H,12-17,19H2,(H,27,31)(H,28,32)
InChi Key	FAIFAFUXFFWVNQ-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCNC(=O)C4=CC5=CC=CC=C5C=C4
Isomeric SMILES	C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCNC(=O)C4=CC5=CC=CC=C5C=C4
PubChem CID	25105715
Molecular Weight	428.53

Solubility

Soluble in DMSO (~20 mg/ml), DMF (~20 mg/ml), and 1:1 solution of DMSO: PBS (pH 7.2) (~0.5 mg/ml).

Refractive Index

n20D1.69 (Predicted)

Boil Point(°C)

~756.6° C at 760 mmHg (Predicted)

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Basic Description