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CB-839 - 98%, high purity , Glutaminase kidney isoform, mitochondrial inhibitor, CAS No.1439399-58-2, Glutaminase kidney isoform, mitochondrial inhibitor
Basic Description Synonyms A14396 | BCP28287 | FT-0767818 | U6CL98GLP4 | A857288 | EX-A1310 | MFCD28167826 | AS-75090 | HMS3873G13 | NCGC00356145-11 | WHO 10815 | 1439399-58-2 | 2-Pyridineacetamide, N-(5-(4-(6-((2-(3-(trifluoromethoxy)phenyl)acetyl)amino)-3-pyridazinyl)butyl)-1,3,4 Specifications & Purity Moligand™, ≥98% Storage Temp Protected from light,Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Glutaminase kidney isoform, mitochondrial inhibitor Product Description Biochemical mechanism:
Cell permeable: yes
Primary Target
GLS1
Reversible: yes
Target IC50: 23 nM & 28 nM, respectively, using murine kidney and brain homogenates
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers Pubchem Sid 488202265 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488202265 IUPAC Name N-[6-[4-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]butyl]pyridazin-3-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide INCHI InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38) InChi Key PRAAPINBUWJLGA-UHFFFAOYSA-N Canonical SMILES C1=CC=NC(=C1)CC(=O)NC2=NN=C(S2)CCCCC3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OC(F)(F)F Isomeric SMILES C1=CC=NC(=C1)CC(=O)NC2=NN=C(S2)CCCCC3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OC(F)(F)F PubChem CID 71577426 Molecular Weight 571.57
Chemical and Physical Properties Solubility Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly Sensitivity light sensitive Melt Point(°C) 186- 189° C
References 1. Gross MI, Demo SD, Dennison JB, Chen L, Chernov-Rogan T, Goyal B, Janes JR, Laidig GJ, Lewis ER, Li J et al. . (2014) Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer.. Mol Cancer Ther, 13 (4): (890-901). [PMID:24523301 ]
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H2407268