CB1954 - 98%, high purity , CAS No.21919-05-1

Item Number

C413845

• Synonyms: Tretazicar | 21919-05-1 | CB 1954 | 5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE | CB1954 | 5-(1-Aziridinyl)-2,4-dinitrobenzamide | 5-Aziridino-2,4-dinitrobenzamide | CB-1954 | Tretazicar [INN] | 5-Aziridinyl-2,4-dinitrobenzamide | Benzamide,5-(1-aziridinyl)-2,4-dinitro- | 2,4-Dinit
• Specifications & Purity: ≥98%
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

Information

CB1954 (Tretazicar, NSC 115829) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into apotent cytotoxic bifunctional alkylating agent. It can be activated byNAD(P)H quinone oxidoreductase 2.

In vitro

The overexpression of nitroreductase oxidored nitro domain containing protein 1 (NOR1) is capable of converting the monofunctional alkylating agent CB1954 into a toxic form by reducing the 4 nitro group of CB1954 which is a potent cytotoxins. Toxic CB1954 enhances cells killing in the NPC cell line CNE1. the NOR1 gene enhances CB1954 mediated cell cytotoxicity through the upregulation of Grb2 expression and the activation of MAPK signal transduction in the HepG2 cell line

In vivo

The NTR/CB1954 system are used to specific ablation of cells in vivo. The effect of this inducible ablation system is dose-dependent. NTR-mediated cell killing by CB1954 does not require cell proliferation. The activated CB1954 cross-links DNA which presumably triggers the apoptosis cascade, resulting in rapid cell death. specific and effective cells killing by NTR-CB1954 does not require a functional p53.

Cell Research(from reference)

Concentrations：4-10 μmol/L 

Application

CB 1954 has been used in drug-induced ablation studies.