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Voltage-gated ion channels
Transient Receptor Potential channels (TRP)
CBA - ≥98%(HPLC), high purity , CAS No.351424-20-9, Channel blocker of TRPM4;Gating inhibitor of TRPM4

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CBA - ≥98%(HPLC), high purity , CAS No.351424-20-9, Channel blocker of TRPM4;Gating inhibitor of TRPM4

1 Citations

Moligand™

≥98%(HPLC)

CAS#: 351424-20-9
Formula: C₁₅H₁₁Cl₂NO₄
Molecular Weight: 340.16
PubChem CID: 2264067

Item Number

C288513

Grouped product items
SKU	Size	Availability	Price
C288513-5mg	5mg	In stock	$45.90
C288513-10mg	10mg	In stock	$75.90
C288513-25mg	25mg	In stock	$162.90
C288513-50mg	50mg	In stock	$271.90
C288513-100mg	100mg	In stock	$434.90

Selective TRPM4 blocker

View related series

Membrane Transporter/Ion Channel Neuronal Signaling TRP Channel TRPM4 Channel blocker TRPM4 Gating inhibitor

Basic Description

Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective TRPM4 blocker (IC50= 1.5 μM). Exhibits no significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a range of other ion channels and receptors. Displays neuroprotective effects against glutamate-induced neurodegenerationin vitro
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	CHANNEL BLOCKER, GATING INHIBITOR
Mechanism of action	Channel blocker of TRPM4;Gating inhibitor of TRPM4

Associated Targets(Human)

TRPM4 Tchem Transient receptor potential cation channel subfamily M member 4 (2 Activities)

Discover Target: TRPM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
INCHI	InChI=1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21)
InChi Key	CVQCJPCMPGKEDH-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C(=C1)OCC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)Cl
Isomeric SMILES	C1=CC=C(C(=C1)OCC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)Cl
PubChem CID	2264067
Molecular Weight	340.16

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
I2208638	Certificate of Analysis	Jul 06, 2022	C288513
I2208639	Certificate of Analysis	Jul 06, 2022	C288513
I2208700	Certificate of Analysis	Jul 06, 2022	C288513
I2208701	Certificate of Analysis	Jul 06, 2022	C288513
I2208702	Certificate of Analysis	Jul 06, 2022	C288513

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 17.01, Max Conc. mM: 50

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jinlong Cao, Zhen Zhang, Lin Ye, Xiaowen Zhao. (2023) Construction of poly(vinyl alcohol)-based ionogels with continuous ion transport channels enables high performance ionic soft actuators. Journal of Materials Chemistry A, 11 (37): (19981-19995). [PMID:] [10.1039/D3TA03726F]

References

1. Jinlong Cao, Zhen Zhang, Lin Ye, Xiaowen Zhao. (2023) Construction of poly(vinyl alcohol)-based ionogels with continuous ion transport channels enables high performance ionic soft actuators. Journal of Materials Chemistry A, 11 (37): (19981-19995). [PMID:] [10.1039/D3TA03726F]

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