JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

྾

CBL0137 - 10mM in DMSO, high purity , CAS No.1197996-80-7

Item Number

C420875

Grouped product items
SKU	Size	Availability	Price	Qty
C420875-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$203.90

NF-κB Inhibitors

Basic Description

Synonyms	cbl0137 \| 1197996-80-7 \| CBL-0137 \| CBL-0137 free base \| Curaxin 137 \| 8XKR07H9ER \| CBL 137; Curaxin 137 \| CHEMBL4640631 \| CBL 0137 \| 1,1'-(9-(2-(isopropylamino)ethyl)-9H-carbazole-3,6-diyl)bis(ethan-1-one) \| 1,1'-(9-(2-(Isopropylamino)ethyl)-9H-carbazole-3,6-diyl)diethanone
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Information CBL0137 CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively. Targets FACT ; p53 (Cell-free assay); NF-κB (Cell-free assay) ; 0.37 μM(EC50); 0.47 μM(EC50)

DNMT3A Tclin DNA (cytosine-5)-methyltransferase 3A (310 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	1-[6-acetyl-9-[2-(propan-2-ylamino)ethyl]carbazol-3-yl]ethanone
INCHI	InChI=1S/C21H24N2O2/c1-13(2)22-9-10-23-20-7-5-16(14(3)24)11-18(20)19-12-17(15(4)25)6-8-21(19)23/h5-8,11-13,22H,9-10H2,1-4H3
InChi Key	JKCSODVERGVDLT-UHFFFAOYSA-N
Canonical SMILES	CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C
Isomeric SMILES	CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C
PubChem CID	44519124
Molecular Weight	336.43

Enter Lot Number to search for COA:

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.