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CC-90011 , CAS No.C608351, Inhibitor of lysine demethylase 1A

Item Number

C608351

Grouped product items
SKU	Size	Availability	Price	Qty
C608351-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C608351-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

Synonyms	Pulrodemstat \| Pulrodemstat [INN] \| W6F4FRQ5QC \| 1821307-10-1 \| CC-90011 Free base \| CC90011 \| CC90011 besylate \| CC-90011 besylate \| 4-(2-(4-Amino-piperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-2-fluorobenzonitrile \| 4-(2-(4-Aminopi
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of lysine demethylase 1A

KDM1A Tchem Lysine-specific histone demethylase 1A (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

INCHI	InChI=1S/C24H23F2N5O2/c1-30-23(32)21(14-5-6-20(33-2)19(26)11-14)22(15-3-4-16(13-27)18(25)12-15)29-24(30)31-9-7-17(28)8-10-31/h3-6,11-12,17H,7-10,28H2,1-2H3
InChi Key	NBAIXBAUHIQQGF-UHFFFAOYSA-N
Canonical SMILES	N#Cc1ccc(cc1F)c1nc(N2CCC(CC2)N)n(c(=O)c1c1ccc(c(c1)F)OC)C
Isomeric SMILES	CN1C(=O)C(=C(N=C1N2CCC(CC2)N)C3=CC(=C(C=C3)C#N)F)C4=CC(=C(C=C4)OC)F
PubChem CID	118483201

Enter Lot Number to search for COA:

1. Fu X, Zhang P, Yu B. (2017) Advances toward LSD1 inhibitors for cancer therapy.. Future Med Chem, 9 (11): (1227-1242). [PMID:28722477] [10.1021/op500134e]
2. Kanouni T, Severin C, Cho RW, Yuen N Y-Y, Xu J, Shi L, Del Rosario JR, Stansfield RK, Lawton LN, Hosfield D et al.. (2020) Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J Med Chem, 71 (13): (1755-70). [PMID:33034194] [10.1021/acs.jmedchem.0c00978]
3. Fang Y, Liao G, Yu B. (2019) LSD1/KDM1A inhibitors in clinical trials: advances and prospects.. J Hematol Oncol, 12 (1): (129). [PMID:31801559] [10.1021/op500134e]

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