CCG 50014 - ≥97%, high purity , CAS No.883050-24-6, Inhibitor of regulator of G-protein signaling 19;Inhibitor of regulator of G-protein signaling 4;Inhibitor of regulator of G-protein signaling 8
CCG 50014 - ≥97%, high purity , CAS No.883050-24-6, Inhibitor of regulator of G-protein signaling 19;Inhibitor of regulator of G-protein signaling 4;Inhibitor of regulator of G-protein signaling 8
Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein (IC50values are 30.1 nM and 11.0μM for RGS4 and RGS8 respectively). Exhibits >20-fold selectivity for RGS4 over other RGS proteins.
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of regulator of G-protein signaling 19;Inhibitor of regulator of G-protein signaling 4;Inhibitor of regulator of G-protein signaling 8
Associated Targets(Human)
RGS19TchemRegulator of G-protein signaling 19 (1 Activities)
1.Blazer LL, Zhang H, Casey EM, Husbands SM, Neubig RR. (2011) A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins.. Biochemistry, 50 (15):(3181-92). [PMID:21329361]
2.Turner EM, Blazer LL, Neubig RR, Husbands SM. (2012) Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins.. ACS Med Chem Lett, 3 (2):(146-150). [PMID:22368763]
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F2210334