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CCG-63802 - 98%, high purity , CAS No.620112-78-9, Inhibitor of regulator of G-protein signaling 4
Inhibitor of regulator of G-protein signaling 4 (RGS4) protein
Basic Description Synonyms CCG-63802 | NCGC00101417-01 | (2E)-2-(1,3-benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile | DTXSID10211064 | GTPL8724 | (E)-2-(1,3-benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxopyrido[1,2 Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Reversible inhibitor of regulator of G-protein signaling (RGS) proteins. Selective amongst RGS proteins, with greatest potency at RGS4. Inhibits GTPase accelerating protein activity of RGS4 and blocks its interaction with Gαo. Retains activity under reduc Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of regulator of G-protein signaling 4
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (E)-2-(1,3-benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile INCHI InChI=1S/C26H18N4O2S/c1-16-7-5-9-19(13-16)32-24-20(26(31)30-12-6-8-17(2)23(30)29-24)14-18(15-27)25-28-21-10-3-4-11-22(21)33-25/h3-14H,1-2H3/b18-14+ InChi Key VFSVKVQMZDJFQX-NBVRZTHBSA-N Canonical SMILES CC1=CC(=CC=C1)OC2=C(C(=O)N3C=CC=C(C3=N2)C)C=C(C#N)C4=NC5=CC=CC=C5S4 Isomeric SMILES CC1=CC(=CC=C1)OC2=C(C(=O)N3C=CC=C(C3=N2)C)/C=C(\C#N)/C4=NC5=CC=CC=C5S4 PubChem CID 6057678 Molecular Weight 450.52
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 2.25, Max Conc. mM: 5 with gentle warming
Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H301: Toxic if swallowed
Precautionary Statements P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
References 1. Blazer LL, Roman DL, Chung A, Larsen MJ, Greedy BM, Husbands SM, Neubig RR. (2010) Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins.. Mol Pharmacol, 78 (3): (524-33). [PMID:20571077 ] [10.1021/op500134e ]
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A2420086