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CCG-63808 - ≥99%, high purity , CAS No.620113-73-7, Inhibitor of regulator of G-protein signaling 4
Basic Description
| Synonyms | alpha-[[2-(4-Fluorophenoxy)-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile | A913696 | AKOS001693904 | CCG-63808 | NCGC00101423-01 | GTPL8725 | MS-28266 | (2E)-2-(1,3-benzothiazol-2-yl)-3-[2-(4-fluorophenoxy)-9-methyl |
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| Specifications & Purity | Moligand™, ≥99% |
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| Biochemical and Physiological Mechanisms |
CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins. |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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| Grade | Moligand™ |
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| Action Type | INHIBITOR |
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| Mechanism of action | Inhibitor of regulator of G-protein signaling 4 |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | (E)-2-(1,3-benzothiazol-2-yl)-3-[2-(4-fluorophenoxy)-9-methyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile |
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| INCHI | InChI=1S/C25H15FN4O2S/c1-15-5-4-12-30-22(15)29-23(32-18-10-8-17(26)9-11-18)19(25(30)31)13-16(14-27)24-28-20-6-2-3-7-21(20)33-24/h2-13H,1H3/b16-13+ |
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| InChi Key | IPZHFKHGSYRBNT-DTQAZKPQSA-N |
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| Canonical SMILES | CC1=CC=CN2C1=NC(=C(C2=O)C=C(C#N)C3=NC4=CC=CC=C4S3)OC5=CC=C(C=C5)F |
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| Isomeric SMILES | CC1=CC=CN2C1=NC(=C(C2=O)/C=C(\C#N)/C3=NC4=CC=CC=C4S3)OC5=CC=C(C=C5)F |
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| PubChem CID | 5948316 |
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| Molecular Weight | 454.49 |
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Chemical and Physical Properties
References
| 1. Blazer LL, Roman DL, Chung A, Larsen MJ, Greedy BM, Husbands SM, Neubig RR. (2010) Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins.. Mol Pharmacol, 78 (3): (524-33). [PMID:20571077] [10.1021/op500134e] |
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