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CCK Octapeptide sulfated, Cholecystokinin A receptor agonist, CAS No.25126-32-3, Cholecystokinin A receptor agonist

  • Moligand™
  • ≥97%
Features and benefits
    Item Number
    C276294
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    C276294-1mg
    1mg
    In stock
    $124.90
    C276294-5mg
    5mg
    In stock
    $379.90
    C276294-10mg
    10mg
    In stock
    $432.90
    C276294-25mg
    25mg
    In stock
    $710.90

    C-terminal ocatapeptide of CCK

    Basic Description

    Product NameCCK Octapeptide sulfated, Cholecystokinin A receptor agonist, CAS No.25126-32-3
    SynonymsSincalide|25126-32-3|CCK-8|Kinevac|Sincalida|Sincalidum|Syncalide|Cholecystokinin octapeptide|CCK C-terminal octapeptide|SQ 19844|Human CCK-8|cholecystokinin C-terminal octapeptide|UNII-M03GIQ7Z6P|M03GIQ7Z6P|DTXSID7048617|SQ-19844|Sincalidum [INN-Latin]|3
    GradeMoligand™
    Product Description

    Sincalide (CCK-8) is a cholecystokinetic drug administered by injection to aid in diagnosing disorders of the gallbladder and pancreas. It is the 8-amino acid C-terminal fragment of cholecystokinin.

    Specifications & PurityMoligand™, ≥97%
    Biochemical and Physiological MechanismsEndogenous C-terminal octapeptide of CCK involved in the neurobiology of anxiety, depression, psychosis, cognition, nociception and feeding behavior.
    SequenceH-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
    Action TypeAGONIST
    Mechanism of actionCholecystokinin A receptor agonist
    NoteThis product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    Product Properties

    ALogP-2.6

    Associated Targets

    CCKAR Tclin Cholecystokinin receptor type A 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    CCKBR Tclin Gastrin/cholecystokinin type B receptor 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    SLCO2B1 Tchem Solute carrier organic anion transporter family member 2B1 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    Storage TempProtected from light,Store at -20°C,Desiccated
    Shipped InIce chest + Ice pads
    CAS25126-32-3

    Certificates

    Certificate of Analysis(COA)

    Enter Lot Number to search for COA:

    To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

    6 results found

    Lot NumberCertificate TypeDateItem
    H2406346Certificate of AnalysisJul 20, 2024 C276294
    H2406347Certificate of AnalysisJul 20, 2024 C276294
    G2201241Certificate of AnalysisApr 14, 2023 C276294
    G2201242Certificate of AnalysisApr 14, 2023 C276294
    G2201243Certificate of AnalysisApr 14, 2023 C276294
    G2201256Certificate of AnalysisApr 14, 2023 C276294

    Genetic information

    Alternate NamesSincalide|25126-32-3|CCK-8|Kinevac|Sincalida|Sincalidum|Syncalide|Cholecystokinin octapeptide|CCK C-terminal octapeptide|SQ 19844|Human CCK-8|cholecystokinin C-terminal octapeptide|UNII-M03GIQ7Z6P|M03GIQ7Z6P|DTXSID7048617|SQ-19844|Sincalidum [INN-Latin]|3
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Yu Y et al..  (2018)  Inducible nitric oxide synthase-derived nitric oxide reduces vagal satiety signalling in obese mice..  J Physiol,      [PMID:30565225]
    2. Everett NA et al..  (2021)  The vagus nerve mediates the suppressing effects of peripherally administered oxytocin on methamphetamine self-administration and seeking in rats..  Neuropsychopharmacology,  46  (2): (297-304).  [PMID:32450570]

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