CCS-1477 (CBP-IN-1) - 10mM in DMSO, high purity , CAS No.2222941-37-7

Item Number

C422663

• Synonyms: Inobrodib | CCS-1477 | 2222941-37-7 | CCS1477 | Inobrodib [INN] | Inobrodib [USAN] | BW5QA5GEW7 | Ccs 1477 | P300/cbp bromodomain inhibitor CCS1477 | CBP-IN-1 | (S)-1-(3,4-Difluorophenyl)-6-(5-(3,5-dimethylisoxazol-4-yl)-1-((1r,4S)-4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-
• Specifications & Purity: 10mM in DMSO
• Biochemical and Physiological Mechanisms: CCS1477（CBP-IN-1, CBP/p300-IN-4）is a potent and selective inhibitor of p300/CBP bromodomain. CCS1477 works by inhibiting the expression and function of the androgen receptor (AR), as well as inhibiting c-Myc.
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads

Product Description

Information

CCS-1477 (CBP-IN-1) CCS1477（CBP-IN-1, CBP/p300-IN-4）is a potent and selective inhibitor of p300/CBP bromodomain . CCS1477 works by inhibiting the expression and function of the androgen receptor (AR) , as well as inhibiting c-Myc .

Targets

p300/CBP bromodomain ; androgen receptor ; c-Myc

In vitro

CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases AR- and C-MYC–regulated gene expression.

In vivo

In AR-SV–driven models, CCS1477 has antitumor activity, regulating AR and C-MYC signaling. Early clinical studies suggest that CCS1477 modulates KLK3 blood levels and regulates CRPC biopsy biomarker expression.

Cell Research(from reference)

Cell lines：22Rv1 cells, C4-2 cells 

Concentrations：500 nM, 96 nM 

Incubation Time：5 hr, 24 hr