Selective, cell-permeable Hsp90 ATPase inhibitor\xa0(IC 50 values are 3.2 μM and 6.6 μM\xa0for Human Hsp90 beta and yeast Hsp90 respectively). Exhibits no detectable effects against Human Hsp72 ATPase or topoisomerase II. Shows antiproliferative effects.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Note
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Product Description
CCT018159, a 3,4-diaryl pyrazoleresorcinol, is a ATP-competitive HSP90 ATPase activity inhibitor with IC50s of 3.2 and 6.6 µM for human Hsp90β and yeast Hsp90, respectively. CCT018159 caused cell cytostasis associated with a G1 arrest and induces apoptosis. CCT018159 inhibits key endothelial and tumor cell functions implicated in invasion and angiogenesis。
Associated Targets(Human)
HSP90AA1TchemHeat shock protein HSP 90-alpha (1 Activities)
1.Sharp SY et al.. (2007) In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.. Cancer Res, 67 (5):(2206-16). [PMID:17332351]
2.Beloueche-Babari M et al.. (2010) Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition.. Oncotarget, 1 (3):(185-97). [PMID:21037799]
3.Dunna NR et al.. (2015) Multiclass comparative virtual screening to identify novel Hsp90 inhibitors: a therapeutic breast cancer drug target.. Curr Top Med Chem, 15 (57-64). [PMID:25579569]
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H2310244