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CCT007093 - 2mM in DMSO, high purity , CAS No.176957-55-4
an inhibitor of Wip1 (PPM1D)
Basic Description Synonyms CCT007093 | 176957-55-4 | 2,5-Bis(2-thienylmethylene)-cyclopentanone | (2E,5E)-2,5-bis(thiophen-2-ylmethylene)cyclopentanone | (2E,5E)-2,5-Bis(2-thienylmethylene)-cyclopentanone | (2E,5E)-2,5-bis[(thiophen-2-yl)methylidene]cyclopentan-1-one | CCT 007093 | MFCD00121546 | Specifications & Purity 2mM in DMSO Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description CCT007093 is an effective PPM1D inhibitor that selectively reduces viability of human tumour cell lines. PPM1D is a phosphatase where the gene which is aberrantly amplified in a range of common cancers. PPM1D activation results in negative regulation of P53 function by selective inactivation of P38 kinase. Therefore, this enzyme can be considered as a potential therapeutic target for cancer. The present study identified a compound, CCT007093 that selectively reduces viability of human tumour cell lines overexpressing PPM1D through inhibition of this phosphatase. The unique advantage of CCT007093 is its ability to mimic the effects of gene-specific PPM1D RNAi, both in its selectivity for human tumour cells that overexpress PPM1D and also by its reliance on an integral P38 pathway.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (2E,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one INCHI InChI=1S/C15H12OS2/c16-15-11(9-13-3-1-7-17-13)5-6-12(15)10-14-4-2-8-18-14/h1-4,7-10H,5-6H2/b11-9+,12-10+ InChi Key KPFZCKDPBMGECB-WGDLNXRISA-N Canonical SMILES C1CC(=CC2=CC=CS2)C(=O)C1=CC3=CC=CS3 Isomeric SMILES C1/C(=C\C2=CC=CS2)/C(=O)/C(=C/C3=CC=CS3)/C1 PubChem CID 2314623 Molecular Weight 272.39
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
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