CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 ( MPS1 ) inhibitor with an IC 50 of 3 nM.
In Vitro
CCT251455 is a highly potent inhibitor of MPS1 that demonstrates high selectivity versus kinases tested in a broad kinome profiling panel. CCT251455 inhibits P-MPS1 with an IC 50 of 0.04 μM in cell-based assay and has a GI 50 of 0.16 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
CCT251455 demonstrates a good oral pharmacokinetic profile in mouse and rat as well as inhibition of MPS1 activity in vivo following oral administration . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 3 nM (MPS1)
Associated Targets(Human)
TTKTchemDual specificity protein kinase TTK (2 Activities)
