| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab006467-10μg | 10μg | In stock | $16.90 | |
| Ab006467-50μg | 50μg | In stock | $49.90 | |
| Ab006467-100μg | 100μg | In stock | $79.90 | |
| Ab006467-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $649.90 |
mAb (RPA-2.10); Mouse anti Human CD2 Antibody; Flow; Unconjugated
| Product Name | CD2 Mouse mAb - Primary antibody, specific to CD2, Mouse IgG1 |
|---|---|
| Synonyms | Erythrocyte receptor | LFA-2 | LFA-3 receptor | Rosette receptor | T-cell surface antigen T11/Leu-5 |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Azide Free, Lot by Lot |
| Host species | Mouse |
| Specificity | CD2 |
| Immunogen | Human phytohemagglutinin-treated lymphoblasts |
| Positive Control | Flow: Human peripheral blood lymphocytes. |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Validated |
| Product Description | Mouse anti Human CD2 Antibody, Monoclonal (RPA-2.10), could be used for Flow and so on. |
| Isotype | Mouse IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 150 kDa |
| Purification Method | Protein G purified |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Stability And Storage | Shipped at 4°C. Store at 4°C long term (12 months). Upon delivery aliquot. |
CD2 Mouse mAb (Ab006467) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD2 with CD2 Mouse mAb (Ab006467) at 0.1 μg/mL (right panel) compared with mouse IgG (Ab170221) - Isotype Control (left panel). Goat anti-Mouse IgG H&L (FITC) (Ab156254) at a dilution of 1/1000 was used as the secondary antibody.
CD2 Mouse mAb (Ab006467) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD2 (red) with CD2 Mouse mAb (Ab006467) at 0.1 μg/mL for 1 hour at 4°C. Goat anti-Mouse IgG H&L (FITC) (Ab156254) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Application | Dilution info |
|---|---|
| Flow Cytometry | 1μg/100w cells "> 1μg/100w cells |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0102388 | Certificate of Analysis | Jan 10, 2024 | Ab006467 |
| ZJ24F0102387 | Certificate of Analysis | Jan 10, 2024 | Ab006467 |
| ZJ24F0102386 | Certificate of Analysis | Jan 10, 2024 | Ab006467 |
| 1. da Silva AJ, Brickelmaier M, Majeau GR, Li Z, Su L, Hsu YM, Hochman PS. (2002) Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells.. J Immunol, 168 (9): (4462-71). [PMID:11970990] [10.1021/op500134e] |
| 2. Giddu S, Subramanian V, Yoon HS, Satyanarayanajois SD.. (2009) Design of beta-hairpin peptides for modulation of cell adhesion by beta-turn constraint.. J Med Chem, 52 (3): (726-736). [PMID:19123855] [10.1021/jm8008212] |
| 3. Gokhale A, Weldeghiorghis TK, Taneja V, Satyanarayanajois SD.. (2011) Conformationally constrained peptides from CD2 to modulate protein-protein interactions between CD2 and CD58.. J Med Chem, 54 (15): (5307-5319). [PMID:21755948] [10.1021/jm200004e] |
| 4. Hahn, W C WC, Menu, E E, Bothwell, A L AL, Sims, P J PJ and Bierer, B E BE.. (1992) Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59.. Science (New York, N.Y.), (26): [PMID:1377404] |
| 5. Seed, B B and Aruffo, A A.. (1987) Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2437578] |
| 6. Peterson, A A and Seed, B B.. (1987) Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2).. Nature, [PMID:2444890] |
| 7. Sayre, P H PH and 7 more authors.. (1987) Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2883656] |
| 8. Diamond, D J DJ, Clayton, L K LK, Sayre, P H PH and Reinherz, E L EL.. (1988) Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2894031] |
| 9. Lang, G G and 7 more authors.. (1988) The structure of the human CD2 gene and its expression in transgenic mice.. The EMBO journal, [PMID:2901953] |
| 10. Sewell, W A WA, Brown, M H MH, Dunne, J J, Owen, M J MJ and Crumpton, M J MJ.. (1986) Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3490670] |
| 11. Wyss, D F DF and 8 more authors.. (1995) Conformation and function of the N-linked glycan in the adhesion domain of human CD2.. Science (New York, N.Y.), (1): [PMID:7544493] |
| 12. Withka, J M JM and 5 more authors.. (1993) Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2.. Structure (London, England : 1993), (15): [PMID:7915183] |
| 13. Bodian, D L DL, Jones, E Y EY, Harlos, K K, Stuart, D I DI and Davis, S J SJ.. (1994) Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution.. Structure (London, England : 1993), (15): [PMID:7994575] |
| 14. Li, J J and 7 more authors.. (1998) A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.. The EMBO journal, (15): [PMID:9857189] |
| 15. Wang, J H JH and 7 more authors.. (1999) Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors.. Cell, (11): [PMID:10380930] |
| 16. Chen, X X, Ji, Z L ZL and Chen, Y Z YZ.. (2002) TTD: Therapeutic Target Database.. Nucleic acids research, (1): [PMID:11752352] |
| 17. and Ortonne, J-P JP.. (2003) Clinical response to alefacept: results of a phase 3 study of intramuscular administration of alefacept in patients with chronic plaque psoriasis.. Journal of the European Academy of Dermatology and Venereology : JEADV, [PMID:12795770] |
| 18. Goedkoop, Amber Y AY and 8 more authors.. (2004) Alefacept therapy reduces the effector T-cell population in lesional psoriatic epidermis.. Archives of dermatological research, [PMID:14968366] |
| 19. Gregory, S G SG and 178 more authors.. (2006) The DNA sequence and biological annotation of human chromosome 1.. Nature, (18): [PMID:16710414] |
| 20. Sjöblom, Tobias T and 28 more authors.. (2006) The consensus coding sequences of human breast and colorectal cancers.. Science (New York, N.Y.), (13): [PMID:16959974] |
| 21. Larsen, R R, Ryder, L P LP, Svejgaard, A A and Gniadecki, R R.. (2007) Changes in circulating lymphocyte subpopulations following administration of the leucocyte function-associated antigen-3 (LFA-3)/IgG1 fusion protein alefacept.. Clinical and experimental immunology, [PMID:17403057] |
| 22. Chamian, Francesca F and 11 more authors.. (2007) Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis.. Journal of translational medicine, (7): [PMID:17555598] |
| 23. Grier, Jennifer T JT and 8 more authors.. (2012) Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity.. The Journal of clinical investigation, [PMID:23006327] |
