CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.Potent, cell-permeable RARγ-selective agonist (EC 50 values are 140, 28 and 7 nM for RAR-α, β and γ respectively). Shows RARγ-dependent and -inde
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of Retinoic acid receptor-γ
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
CD 437 is a synthetic, cell-permeable, retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer. CD 437 is an activator of RAR γ. A cell-permeable retinoid-related molecule tumor growth arrest and apoptosis inducer
1.Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N, Conery AL, Shen S, Pan W et al.. (2018) A new class of synthetic retinoid antibiotics effective against bacterial persisters.. Nature, 556 (7699):(103-107). [PMID:29590091]
2.Su X et al.. (2020) Retinoic acid receptor gamma is targeted by microRNA-124 and inhibits neurite outgrowth.. Neuropharmacology, 163 (107657). [PMID:31170403]
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H1725041