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SKU | Size | Availability | Price | Qty |
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C274883-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $553.90 |
Potent, selective lipoxygenase inhibitor
Synonyms | A-cyanocinnamate | CINNAMYL-3,4-DIHYDROXY-ALPHA-CYANOCINNAMATE | HY-138688 | SCHEMBL9215428 | 2-Cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid 3-phenyl-allyl ester | CS-0166637 | CDC | 2-Cyano-3-(3,4-dihydroxyphenyl)-3-phenyl-2-propenyl ester-2-propenoic aci |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Potent, selective 12-Lipoxygenase (12-LO) inhibitor (IC 50 = 63 nM). Also inhibits 15-LO and 5-LO (IC 50 values are 3.33 and 1.89 μM respectively). Active in vivo . |
Storage Temp | Room temperature |
Shipped In | Normal |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at Room Temperature. The product can be stored for up to 12 months. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | [(E)-3-phenylprop-2-enyl] (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoate |
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INCHI | InChI=1S/C19H15NO4/c20-13-16(11-15-8-9-17(21)18(22)12-15)19(23)24-10-4-7-14-5-2-1-3-6-14/h1-9,11-12,21-22H,10H2/b7-4+,16-11+ |
InChi Key | XGHYFEJMJXGPGN-UYHGDYIZSA-N |
Canonical SMILES | C1=CC=C(C=C1)C=CCOC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N |
Isomeric SMILES | C1=CC=C(C=C1)/C=C/COC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N |
PubChem CID | 14840979 |
Molecular Weight | 321.33 |
CAS Registry No. | 132465-11-3 |
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PubChem CID | 14840979 |
ChEMBL Ligand | CHEMBL37141 |
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Solubility | Soluble in DMSO to 10 mM and in ethanol to 10 mM |
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Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H317:May cause an allergic skin reaction H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. |
1. Körner A et al.. (2019) Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A.. Nat Commun, 10 (633). [PMID:30733433] |