CDK9-IN-7 - 99%, high purity , CAS No.2369981-71-3

Item Number

C650913

• Specifications & Purity: ≥99%
• Biochemical and Physiological Mechanisms: CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor ( IC 50 =11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious to
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor ( IC 50 =11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious toxicity. CDK9-IN-7 induces NSCLC cell apoptosis , arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLC

In Vitro

CDK9-IN-7 displays exceptional potency against NSCLC cell lines, especial A549 and H1299 with IC 50 values less than 0.5 µM. In the drug-resistant NSCLC cell line H1975, CDK9-IN-7 also exhibits good inhibition potency with an IC 50 value of 0.837 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:CDK9/cyclinT1 11 nM (IC 50 ) CDK4/cyclin D 148 nM (IC 50 ) CDK6/cyclinD 145 nM (IC 50 )