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Cediranib - ≥98%, high purity , Vascular endothelial growth factor receptor inhibitor, CAS No.288383-20-0, Vascular endothelial growth factor receptor inhibitor
Basic Description Synonyms Cediranib|288383-20-0|Recentin|AZD2171|Cedirannib|Cediranib (AZD2171)|AZD-2171|4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline|AZD 2171|Cediranib free base|4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyr Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Cediranib is VEGFR2 inhibitor. Cediranib inhibited VEGF-stimulated proliferation and KDR phosphorylation with IC50s of 0.4 and 0.5 nM, respectively. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Vascular endothelial growth factor receptor inhibitor Product Description Cediranib (AZD2171) is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3, Phase 3.
Names and Identifiers IUPAC Name 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline INCHI InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3 InChi Key XXJWYDDUDKYVKI-UHFFFAOYSA-N Canonical SMILES CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5 Isomeric SMILES CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5 PubChem CID 9933475 Molecular Weight 450.52
Chemical and Physical Properties Solubility DMSO 90 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Safety and Hazards(GHS) Pictogram(s) GHS06 , GHS08 , GHS09 , GHS07 Signal Danger Hazard Statements H315: Causes skin irritation
H301: Toxic if swallowed
H312: Harmful in contact with skin
H410: Very toxic to aquatic life with long lasting effects
H372: Causes damage to organs through prolonged or repeated exposure
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P362+P364: Take off contaminated clothing and wash it before reuse.
P391: Collect spillage.
P330: Rinse mouth.
P203: Obtain, read and follow all safety instructions before use.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
P318: if exposed or concerned, get medical advice.
P317: Get emergency medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
References 1. Wedge SR, Kendrew J, Hennequin LF, Valentine PJ, Barry ST, Brave SR, Smith NR, James NH, Dukes M, Curwen JO et al. . (2005) AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer.. Cancer Res, 65 (10): (4389-400). [PMID:15899831 ]
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B1525010