Highly selective multidrug resistance protein 4 (MRP4) inhibitor
Basic Description
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC 50 = 1.5 µM). Blocked transport of MRP4 substrates 6-Mercaptopurine, SN 38, cAMP, D-Luciferin and E217βG.
Storage Temp
Store at 2-8°C,Desiccated
Shipped In
Wet ice
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Usuki F et al.. (2017) Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters.. Sci Rep, 7 (12390). [PMID:28959040]
2.Becerra E et al.. (2022) Specific MRP4 Inhibitor Ceefourin-1 Enhances Apoptosis Induced by 6-Mercaptopurine in Jurkat Leukemic Cells, but Not in Normal Lymphoblast Cell Line CRL-1991.. Medicina (Kaunas), 58 (6):[PMID:35743958]
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