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Bioactive Small Molecules
Synthetic organic ligands
cefluprenam , CAS No.116853-25-9

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cefluprenam , CAS No.116853-25-9

Moligand™

CAS#: 116853-25-9
PubChem CID: 6536774

Item Number

C608452

Grouped product items
SKU	Size	Availability	Price	Qty
C608452-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,600.90
C608452-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,800.90

Basic Description

Synonyms	CEFLUPRENAM [JAN] \| (6R,7R)-7-((E)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-((fluoromethoxy)imino)acetamido)-3-((E)-3-((2-amino-2-oxoethyl)(ethyl)(methyl)ammonio)prop-1-en-1-yl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate \| Cefluprenam \| AKOS040748
Specifications & Purity	Moligand™
Grade	Moligand™

Associated Targets(Human)

SLC15A1 Tchem Oligopeptide transporter small intestine isoform (922 Activities)

Discover Target: SLC15A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Slc15a2 Oligopeptide transporter, kidney isoform (114 Activities)

Discover Target: Slc15a2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(6R,7R)-3-[(E)-3-[(2-amino-2-oxoethyl)-ethyl-methylazaniumyl]prop-1-enyl]-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(fluoromethoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
INCHI	InChI=1S/C20H25FN8O6S2/c1-3-29(2,7-11(22)30)6-4-5-10-8-36-18-13(17(32)28(18)14(10)19(33)34)24-16(31)12(26-35-9-21)15-25-20(23)37-27-15/h4-5,13,18H,3,6-9H2,1-2H3,(H5-,22,23,24,25,27,30,31,33,34)/b5-4+,26-12-/t13-,18-,29?/m1/s1
InChi Key	XAKKNLNAJBNLPC-MAYKBZFQSA-N
Canonical SMILES	CC[N+](C)(CC=CC1=C(N2C(C(C2=O)NC(=O)C(=NOCF)C3=NSC(=N3)N)SC1)C(=O)[O-])CC(=O)N
Isomeric SMILES	CC[N+](C)(C/C=C/C1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OCF)/C3=NSC(=N3)N)SC1)C(=O)[O-])CC(=O)N
Alternate CAS	116853-25-9
PubChem CID	6536774
MeSH Entry Terms	7-(2-(5-amino-1,2,4-thiadiazol-3-yl)-2-fluoromethoxyiminoacetoamido)-3-(3-carbamoylmethylethylmethylammonio-1-propenyl)-8-oxo-5-thia-1-azabicyclo(4,2,0)oct-2-ene-2-carboxylate;cefluprenam;E 1077;E-1077;E1077

Database links

PubChem CID	6536774
CAS Registry No.	116853-25-9
ChEMBL Ligand	CHEMBL2074822
Antibiotic DB	357, 349

Certificates

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References

1. Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V. (2000) beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter.. J Biol Chem, 275 (3): (1699-707). [PMID:10636865] [10.1021/op500134e]
2. Watanabe N, Hiruma R, Katsu K. (1992) In vitro evaluation of E1077, a new cephalosporin with a broad antibacterial spectrum.. Antimicrob Agents Chemother, 36 (3): (589-97). [PMID:1622167] [10.1021/op500134e]
3. Toyosawa T, Miyazaki S, Tsuji A, Yamaguchi K, Goto S. (1993) In vitro and in vivo antibacterial activities of E1077, a novel parenteral cephalosporin.. Antimicrob Agents Chemother, 37 (1): (60-6). [PMID:8431019] [10.1021/op500134e]

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