cefluprenam , CAS No.116853-25-9

Item Number

C608452

Grouped product items
SKU	Size	Availability	Price	Qty
C608452-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,600.90
C608452-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,800.90

Basic Description

Synonyms	Cefluprenam \| 116853-25-9 \| Cefluprenam [INN] \| Antibiotic E 1077 \| E 1077 \| 098633Q42P \| (-)-((E)-3-((6R,7R)-7-(2-(5-Amino-1,2,4-thiadiazol-3-yl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo (4.2.0)oct-2-en-3-yl)allyl)(carbamoylmethyl)ethylmethylammonium hydroxi
Specifications & Purity	Moligand™
Grade	Moligand™

Associated Targets(non-human)

Slc15a2 Oligopeptide transporter, kidney isoform (114 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc22a5 Solute carrier family 22 member 5 (44 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(6R,7R)-3-[(E)-3-[(2-amino-2-oxoethyl)-ethyl-methylazaniumyl]prop-1-enyl]-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(fluoromethoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
INCHI	InChI=1S/C20H25FN8O6S2/c1-3-29(2,7-11(22)30)6-4-5-10-8-36-18-13(17(32)28(18)14(10)19(33)34)24-16(31)12(26-35-9-21)15-25-20(23)37-27-15/h4-5,13,18H,3,6-9H2,1-2H3,(H5-,22,23,24,25,27,30,31,33,34)/b5-4+,26-12-/t13-,18-,29?/m1/s1
InChi Key	XAKKNLNAJBNLPC-MAYKBZFQSA-N
Canonical SMILES	CC[N+](C)(CC=CC1=C(N2C(C(C2=O)NC(=O)C(=NOCF)C3=NSC(=N3)N)SC1)C(=O)[O-])CC(=O)N
Isomeric SMILES	CC[N+](C)(C/C=C/C1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OCF)/C3=NSC(=N3)N)SC1)C(=O)[O-])CC(=O)N
Alternate CAS	116853-25-9
PubChem CID	6536774
MeSH Entry Terms	7-(2-(5-amino-1,2,4-thiadiazol-3-yl)-2-fluoromethoxyiminoacetoamido)-3-(3-carbamoylmethylethylmethylammonio-1-propenyl)-8-oxo-5-thia-1-azabicyclo(4,2,0)oct-2-ene-2-carboxylate;cefluprenam;E 1077;E-1077;E1077

PubChem CID

CAS Registry No.

ChEMBL Ligand

Antibiotic DB

References

1. Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V. (2000) beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter.. J Biol Chem, 275 (3): (1699-707). [PMID:10636865]
2. Watanabe N, Hiruma R, Katsu K. (1992) In vitro evaluation of E1077, a new cephalosporin with a broad antibacterial spectrum.. Antimicrob Agents Chemother, 36 (3): (589-97). [PMID:1622167]
3. Toyosawa T, Miyazaki S, Tsuji A, Yamaguchi K, Goto S. (1993) In vitro and in vivo antibacterial activities of E1077, a novel parenteral cephalosporin.. Antimicrob Agents Chemother, 37 (1): (60-6). [PMID:8431019]

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Basic Description